Transporters and Solute carriers
@solutecarriersPapers, notes and conferences about #solutecarriers and other #transporters. Edited by @e_girardi
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New work from @DelgoffeLab; exhausted T cells in tumours are unique in their expression of Slc16a11 (MCT1) - exciting new target to improve CD8 anti tumour functions Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism rdcu.be/dZWcd
SLC13A3 story 1 (the beneficial one ✅): SLC13A3 was recently discovered to be an itaconate importer that improves hepatic antibacterial innate immunity cell.com/developmental-… @Dev_Cell
Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistancel cell.com/cancer-cell/fu…
Unraveling the socio-cognitive consequences of KCC2 disruption in zebrafish: implications for neurodevelopmental disorders and therapeutic interventions frontiersin.org/journals/molec…
Hepatocyte-specific SLC27A4 deletion ameliorates nonalcoholic fatty liver disease in mice via suppression of phosphatidylcholine-mediated PXR activation sciencedirect.com/science/articl…
Membrane potential stimulates ADP import and ATP export by the mitochondrial ADP/ATP carrier due to its positively charged binding site | Science Advances science.org/doi/10.1126/sc… Congrats Edmund @solutecarriers lab!
The zinc transporter Slc30a1 (ZnT1) in macrophages plays a protective role against attenuated Salmonella doi.org/10.7554/eLife.…
Facilitation of Mg2+ Extrusion by the Murine Distal Convoluted Tubule-Specific Isoform of SLC41A3 journals.lww.com/jasn/citation/…
Fluorescent non-canonical amino acid provides insight into the human serotonin transporter nature.com/articles/s4146…
Genetically encoded green fluorescent sensor for probing sulfate transport activity of solute carrier family 26 member a2 (Slc26a2) protein nature.com/articles/s4200…
Evolution, classification, and mechanisms of transport, activity regulation, and substrate specificity of ZIP metal transporters tandfonline.com/doi/abs/10.108…
Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer nature.com/articles/s4141…
The deubiquitinase OTUD5 stabilizes SLC7A11 to promote progression and reduce paclitaxel sensitivity in triple-negative breast cancer sciencedirect.com/science/articl…
Mitochondrial pyruvate carriers control airway basal progenitor cell function through glycolytic-epigenetic reprogramming cell.com/cell-stem-cell…
Structure–Activity Relationships and Target Selectivity of Phenylsulfonylamino-Benzanilide Inhibitors Based on S1647 at the SLC10 Carriers ASBT, NTCP, and SOAT pubs.acs.org/doi/full/10.10…
Are you curious what is known about SLCs? And how they are related? We are enthusiastic to wrap up the series of four (4) manuscripts by presenting the data- and knowledge-derived functional landscape of human solute carriers #SLC : biorxiv.org/content/10.110…
Structural basis for antibiotic transport and inhibition in PepT2 nature.com/articles/s4146…
Glucose Transporter-Targeting Chimeras Enabling Tumor-Selective Degradation of Secreted and Membrane Proteins pubs.acs.org/doi/abs/10.102…
We are thrilled to share the THIRD study of our series which sheds light on the genetic interactions between transporters and links them to the metabolic network: doi.org/10.1101/2024.1…
LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR nature.com/articles/s4158…
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RESOLUTE - Research Empowerment on Solute Carriers
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International Transmembrane Transporter Society
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David B Sauer
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