Markus Rinschen
@mrins01Assoc. Prof @AarhusUni /UKE @unihh. Why do kidneys fail? Kidney physiology, ‚‘omics, translation & integrative studies. @[email protected]
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Our study on metabolic communication by SGLT2 inhibition is now online @circaha We describe how SGLT2 inhibitors provide metabolic kidney and heart protection, by systematic analysis of early and off-target effects of the drug across metabolic organs in the same mice.
Final #AMMS 9/24 will focus on activity metabolomics/lipidomics with three rising stars: @MartinGiera “Endogenous to the Clinic” Shuo Han @theHanLab “Gut Microbiome and Bioactive Metabolites” Markus Rinschen @mrins01 “Cross-Organ Disease Modulation” masspec.scripps.edu/about/AMMS-Sho…
1/16) We are excited to share our recent paper “ADAMTS12 promotes fibrosis by restructuring extracellular matrix to enable activation of injury-responsive fibroblasts” published today @Jclinicalinvest led by @KonradHoeft and @Lars_K0ch jci.org/articles/view/…
📣📣📣 #KidneyCamp is on!!! 📣📣📣 I repeat, Kidney Camp is back on - Summer 2026!!! 🤩🫘☀️Thanks to @APSPhysiology !! Stay tuned for more details! @clintoria @jenpluznick @DrKeeksPhD @KidneyInCVD @staruschenko @313Kidney please spread the news! 🤩
This review paper on kidney amino acid metabolism and metabolomics in health and disease is now online. This work was led by Martine Knol, visiting MD/PhD student in the lab, Vera Wulfmeyer, nephrologist in the lab, and @MuellerRom Hope it is useful!
New online! @mrins01 and colleagues review the metabolic role of the kidney in amino acid metabolism go.nature.com/3X7d8WF
Spread the word- The Epithelial Transport Group has a new Twitter/X handle! Follow us for updates regarding new research, upcoming conferences, and career development!
Happy to share our recent article published in AJP Cell Physiology. journals.physiology.org/doi/abs/10.115… @AJPCellPhys @AJPCellPhysEIC
Presented at #ERA24: Antinephrin autoantibodies occur in adults with minimal change disease and children with idiopathic nephrotic syndrome and appear to be disease activity markers. Their binding at slit diaphragms may induce podocyte dysfunction. nej.md/3UU5o9u
Third @NEJM simultaneous publication at #ERA24 bravo @Tobias_B_Huber and team!! Autoantibodies targeting nephrin in podocytopathies nejm.org/doi/full/10.10…
Hamburg-@ERA24 news: @Tobias_B_Huber now presenting the results on anti-nephrin autoantibodies in podocytopathies. Highly collaborative work on behalf of the @ISGDtweets @NicolaMTomas @hengel_f @pi_ronco @mrins01 @moritz_lasse @AstridWeins @UKEHamburg
#ERA24 and @ISGDtweets highlight! Tobi Huber showing his lab’s incredible results expanding anti-nephrin antibody studies in diffuse podocytopathies and proving pathogenicity in the mouse. Proud to have sparked the field and inspired this breakthrough. #newideasnewtherapiesforNS
Our recent mini-review with @lashodya @OPalygin in Current Opinion in Nephrology and Hypertension. "Lysine and salt-sensitive hypertension" journals.lww.com/co-nephrolhype…
Excited to share our work on a new regulatory mechanism of kidney tissue regeneration by macula densa cells led by @gyarmatigina jci.org/articles/view/…
In 2022, researchers showed the kinase VPS34 adjusts #endocytosis, nutrient transport, and antiviral responses in the kidneys, hinting it may be a therapeutic target to protect this organ from viral infections. @mrins01 @UKEHamburg #WeekendReads scim.ag/6fw
Kidney disease boils down to kidney metabolism - this not only rewires the kidney, but also starts metabolic organ communication. Here, we reviewed integrative views of metabol(om)ic data in the kidney. annualreviews.org/doi/abs/10.114…
Congrats @mrins01 and team and thanks for involving us! Glad our @DugourdAjf R. Fallegger @JulioSaezRod could help to analyse this multi-omics data to understand the effect of SGLT2 inhibitors
Our study on metabolic communication by SGLT2 inhibition is now online @circaha We describe how SGLT2 inhibitors provide metabolic kidney and heart protection, by systematic analysis of early and off-target effects of the drug across metabolic organs in the same mice.
Metabolic Communication by SGLT2 Inhibition 👉 SGLT2i ⤵️ microbiome formation of uremic toxins such as p-cresol sulfate 👉their body exposure and need for renal detoxification, which, combined with direct kidney effects of SGLT2i, including ⤵️ proximal tubule glucotoxicity and a…
Happy to contribute a bit to this critical study by @mrins01, Anja M. Billing, Volker Vallon, and others, providing new insights into the mechanism of SGLT2i actions. "Metabolic Communication by SGLT2 Inhibition" @CircAHA ahajournals.org/doi/10.1161/CI…
Metabolic Communication by SGLT2 Inhibition | @CircAHA Excellent work by @mrins01 Vallon @staruschenko @kadzuis @JulioSaezRod @Tobias_B_Huber and many more... #2024 #Cardiorenalmetabolism studies are off to a great start ahajournals.org/doi/10.1161/CI…
This very cool and comprehensive study shows that the mechanism of action of Sglt2i involves broad remodeling of kidney metabolite transport, & microbiome changes (including reductions in p-cresol sulfate). Congrats to @mrins01 and Volker Vallon, et al (including @staruschenko)!
Happy to contribute a bit to this critical study by @mrins01, Anja M. Billing, Volker Vallon, and others, providing new insights into the mechanism of SGLT2i actions. "Metabolic Communication by SGLT2 Inhibition" @CircAHA ahajournals.org/doi/10.1161/CI…
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