Oli B. Clarke
@OliBClarkeCrystallography, cryoEM, model building, ion channels, etc. NY now, formerly Melb, Aus.
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1/x: Happy to share our new #cryoem @biorxivpreprint: “Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene”, lead by outstanding student Dr. Kookjoo Kim! Read on: 🧵 biorxiv.org/content/10.110…
Apologies for the spam but a reminder that today is the **last day** to nominate yourself for CryoEM Subgroup leadership! See position descriptions and link in Liz's post below - it is a great opportunity for folks at all career stages to get involved with the cryoEM community!
Hello @BiophysicalSoc Cryo-EM Subgroup Members, As we approach the 2025 Biophysical Society Annual Meeting in Los Angeles, we need nominations for 5 Cryo-EM Subgroup leadership positions. This is a great chance to become more involved with the Society and to support the Cryo-EM…
Final opportunity to submit nominations for the Almeida award - closing November 15th!!
Dear cryo-EM women scientists, We want to honor you and your contributions at BPS 2025. This year, the Cryo-EM subgroup will honor a mid/senior-career woman scientist as the inaugural June Almeida awardee. June Almeida is the virologist who first discovered the coronavirus in…
Last chance to nominate for BPS CryoEM subgroup leadership, closing November 15th!!
Hello @BiophysicalSoc Cryo-EM Subgroup Members, As we approach the 2025 Biophysical Society Annual Meeting in Los Angeles, we need nominations for 5 Cryo-EM Subgroup leadership positions. This is a great chance to become more involved with the Society and to support the Cryo-EM…
The #AlphaFold 3 model code and weights are now available for academic use. We @GoogleDeepMind are excited to see how the research community continues to use AlphaFold to address open questions in biology and new lines of research. github.com/google-deepmin…
We love the excitement & results from the community on AlphaFold 3 and are doubling the AF Server daily job limit to 20. Happy to also share that we're working on releasing the AF3 model (incl weights) for academic use, which doesn’t depend on our research infra, within 6 months.
(1/6) Excited to share my latest paper published in @MolecularCell ! Combining structural and developmental biology @ZuckermanBrain we investigated the function of the sevenless receptor tyrosine kinase. authors.elsevier.com/c/1k3563vVUPRn…
I see posts like this all the time and it made me wonder if there is a journal out there where such observations could be documented and reported? In the crystallography field, they might end up somewhere like Acta Cryst F? Could be an option for us EMers?
An uninvited guest join the ApoFe party from last Monday... anyone can help identifying this annoying fellow....👇
Imagine a dataset where it's the whole of the AlphaFold Database but you can pull-out the domain-like structures avoiding random spaghetti, or get all the domain-domain interactions, or check whether domains match a known structural super-family. That's TED:
TED: The Encyclopedia of Domains now published in @ScienceMagazine discovering and annotating 314 MILLION protein domains in the AlphaFold database. joint work of @CATH_Gene3D and @psipred here at UCL.
Want to Structure, Function, Surf, Repeat?! @LorneProteins is renowned for being an outstanding international protein conference in a beautiful Aussie beach town. Have a read to get a feel and hope to see you all at the 50th anniversary meeting! 🏖️🔬🧪💭 authors.elsevier.com/c/1k3Rh3SNvcAc…
After a very dark couple of days in the world feeling rather helpless, this was a real bright spot! Thank you so much to @RosemaryJCater for hosting and to @FarrahBlades for making everything run so smoothly!
This week we had the pleasure of hosting cryo-EM guru @OliBClarke who gave the @UQ_News cryo-EM community a fantastic cryo-EM data-processing workshop. Thank you Oli for sharing your tricks with us, @FarrahBlades for wrangling the Bunya supercomputer, and all who attended! 🔬
This week we had the pleasure of hosting cryo-EM guru @OliBClarke who gave the @UQ_News cryo-EM community a fantastic cryo-EM data-processing workshop. Thank you Oli for sharing your tricks with us, @FarrahBlades for wrangling the Bunya supercomputer, and all who attended! 🔬
CZII’s particle picking machine learning challenge is up and running. There are already 1000 signups on Kaggle. Follow this page for an introduction and links to all sorts of material and resources, including two preprints: cryoetdataportal.czscience.com/competition
Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. @befcorreia @sokrypton biorxiv.org/content/10.110…
Please see below and nominate folks to serve on the BPS CryoEM subgroup committee! You’ll get to work with Liz organizing the BPS 2026 meeting, it’ll be a blast! 🤩 🔬 ❄️
Hello @BiophysicalSoc Cryo-EM Subgroup Members, As we approach the 2025 Biophysical Society Annual Meeting in Los Angeles, we need nominations for 5 Cryo-EM Subgroup leadership positions. This is a great chance to become more involved with the Society and to support the Cryo-EM…
Hello @BiophysicalSoc Cryo-EM Subgroup Members, As we approach the 2025 Biophysical Society Annual Meeting in Los Angeles, we need nominations for 5 Cryo-EM Subgroup leadership positions. This is a great chance to become more involved with the Society and to support the Cryo-EM…
🚨 Great alternatives to BioRender are now available!! 📢 @NIAIDNews offers a collection of public figures and icons for everyone to use. Check it out at bioart.niaid.nih.gov
Deadline for the BPS #cryoem subgroup Almeida award has been extended to November 15th, so get your nominations in now! ❄️🔬
Dear cryo-EM women scientists, We want to honor you and your contributions at BPS 2025. This year, the Cryo-EM subgroup will honor a mid/senior-career woman scientist as the inaugural June Almeida awardee. June Almeida is the virologist who first discovered the coronavirus in…
Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM | bioRxiv biorxiv.org/content/10.110…
Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene | bioRxiv biorxiv.org/content/10.110…
🚨#cryoEM structures of MCT8/10 revealed in our lab by talented @Matteo_tassina! 🚨See how #thyroid hormone T4 is transported across membranes 👇. Great collaboration with Visser's lab @erasmusmcintl, thanks to @HumanTechnopole, @ERC_Research, @HorizonEU biorxiv.org/content/10.110…
Diamide insecticides target insect Ryanodine Receptors, but resistance threatens food supplies worldwide. Cryo-EM of a chimeric RyR shows how diamides targets insect RyRs and how resistance is accomplished. nature.com/articles/s4146…
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