RESOLUTE - Research Empowerment on Solute Carriers
@RESOLUTE_IMIThe RESOLUTE & REsolution IMI consortia aim at triggering an escalation in the intensity of research on Solute Carriers (SLCs) transporters worldwide.
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Are you curious what is known about SLCs? And how they are related? We are enthusiastic to wrap up the series of four (4) manuscripts by presenting the data- and knowledge-derived functional landscape of human solute carriers #SLC : biorxiv.org/content/10.110…
We are thrilled to share the THIRD study of our series which sheds light on the genetic interactions between transporters and links them to the metabolic network: doi.org/10.1101/2024.1…
Do you want to know with which proteins an SLC membrane transporter socializes? Our @RESOLUTE_IMI series of 4 manuscripts continues, and we are excited to share the so far most comprehensive interactome mapping of solute carriers biorxiv.org/content/10.110…
We are excited to kick off our series of 4 manuscripts from the RESOLUTE consortium by sharing the metabolic mapping of the Solute Carrier Superfamily (biorxiv.org/content/10.110…)!
Finally! It is happening! After 6 years of hard work by formidable teams in 13 institutions @RESOLUTE_IMI, we have ordered and validated the results and are able to share the FOUR (4) papers aimed at assigning functional properties to each human SLC #membranetransporter
Check out this tour-de-force in technology and assay development by our partners at Novartis, @mpi_mr_hd, and @CeMM_News: dlvr.it/T7Vyjf
Online now! AspSnFR: A genetically encoded biosensor for real-time monitoring of aspartate in live cells by Lars Hellweg, Kai Johnsson, @PLeippe, and colleagues at @EPFL_en @mpi_mr_hd @CeMM_News dlvr.it/T7Vyjf #chembiol
📢Dear followers! It has been an absolute pleasure to share news on Solute Carriers #SLCs transporters with you during the last 5 years! The RESOLUTE @IHIEurope project is ending soon, but all our resources and datasets are available at re-solute.eu. #CarryTheTorch!
Many SLC superfamily #transporters could be included on this schematic, including organellar Na+/H+ exchangers SLC9A9 and SLC9A6.
New online! Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes go.nature.com/3sNkqnh
Structural basis of anticancer drug recognition and amino acid transport by LAT1 | bioRxiv biorxiv.org/content/10.110…
Uncoupled substrate binding underlies the evolutionary switch between Na+ and H+-coupled prokaryotic aspartate transporters | bioRxiv biorxiv.org/content/10.110…
A massive @RESOLUTE_IMI collaboration with @CmdOxford, #nuvisan, @BiochemOxford, @CeMM_News, @Bayer, @UZH_en Work of many many talented colleagues including @ProfSyK, @katharina_duerr, @DJ_Biophys, @BenediktKessler, @AlvaroIngles1, @giuliosf and numerous others
new release1 SpSLC9C1 in lipid nanodiscs apo 8PCZ: dimer 8PD2,3,5,7: protomer state 1-4 w/ cAMP 8PD8: dimer 8PD9: protomer state 1 w/ cGMP 8PDU: dimer 8PDV: protomer "Structures of a sperm-specific solute carrier gated by voltage and cAMP" Paulino lab. Nature.
Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP | Nature Comm disq.us/t/4k7ovfm #CryoEM #ABCtransporter #MembraneProteins
Mimicking the regulatory state of a major facilitator superfamily sugar transporter | eLife doi.org/10.7554/eLife.… #CryoEM #MFStransporter #MembraneProteins
New preprint from the lab and guess what, it is not about a membrane transporter😱: "Sensory kinase KdpD is a tandem serine histidine kinase controlling K+ pump KdpFABC on the translational and post-transcriptional level". A short thread... 1/4 biorxiv.org/content/10.110…
Cryo-EM structure of TMEM63C suggests it functions as a monomer | Nature Comm disq.us/t/4k6wope #CryoEM #MembraneProteins
Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity | Cell Research doi.org/10.1038/s41422… #CryoEM #MembraneProteins
Structural investigation of human cystine/glutamate antiporter system xc− (Sxc−) using homology modeling and molecular dynamics frontiersin.org/articles/10.33…
Energy coupling and stoichiometry of Zn2+/H+ antiport by the prokaryotic cation diffusion facilitator YiiP | eLife doi.org/10.7554/eLife.… #CryoEM #antiporter #MembraneProteins
Our work on the human neuronal vesicular monoamine transporter VMAT2 in online @Nature This work was led by talented scientists Shabareesh Pidathala and Yaxin Dai @YaxinDai, in a wonderful collaboration with Zhe Zhang's lab. nature.com/articles/s4158…
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Who to follow
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Transporters and Solute carriers
@solutecarriers -
David B Sauer
@DavidBSauer -
International Transmembrane Transporter Society
@ITTS_Cure -
LolandLab
@cloland_dk -
Superti-Furga Lab
@gsf_lab -
Simon Newstead
@inwardopen -
Oli B. Clarke
@OliBClarke -
Sonja Sucic 🧬🧠🧪🔬
@SonjaSucic -
Giulio Superti-Furga
@giuliosf -
Manuele Rebsamen
@mrebsamen -
accardilab
@accardilab -
RebsamenLab
@RebsamenLab -
Da-Neng Wang
@danengw -
Loew Group
@AllUNeedIsLoew -
Boudker Lab
@BoudkerLab
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