Nature Metabolism
@NatMetabolismNature Metabolism publishes studies that advance our understanding of metabolic and homeostatic processes in physiology and disease.
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✨New issue!✨ Check out the latest in #metabolism research from across all disciplines. Read about #microbiome, #mitochondria, #extracellularvesicles, #exercise, #genetics, #genomics - and more! nature.com/natmetab/volum…
RESEARCH | J Carrasco-Zanini, @pietznerm, C Langenberg et al. (@berlinnovation, @QMUL): Biological influences on the human plasma #proteome reveal causal associations between plasma proteins and modifiable risk factors for protein–disease associations 👥🧫…
RESEARCH | SL Zhang, QA Jia, Y Wang, ZM Wang et al. (@FudanUni; NPU, CN): Oral administration of the anti-diabetic drug acarbose enhances the efficacy of #cancer anti-PD-1 #immunotherapy in female mice by modulating the gut #microbiota. 🐭🦠💊 nature.com/articles/s4225…
🔊Our editor @nakhle_j will be attending the ✨#MetabolismInAction24 ✨conference by @ScienceCluster in Hillerød, Denmark. Reach out to him if you'd like to chat!
RESEARCH | @carapetop, K Iwasaki, @caguayo et al. (@JoslinDiabetes): #Exercise training decreases pancreatic #islet senescence through #glucagon and #AMPK signaling in mouse and human islets, which could have implications for #T2DM therapeutics.🐭👥 nature.com/articles/s4225…
RESEARCH | N Grankvist, C Jönsson, @roland_nilsson et al. (@karolinskainst): Grankvist et al. combine global isotopic tracing and #metabolic flux modelling to characterize metabolic networks in human intact #liver tissue🧪 nature.com/articles/s4225…
RESEARCH | S Das, AC Finney, @OrenRom1 et al. (@LSUResearch): #Genetic and #pharmacological inhibition of the overproduction of oxalate in the #liver alleviates metabolic dysfunction-associated steatohepatitis in male mice 🐁💉. nature.com/articles/s4225…
RESEARCH | SM Lockhart, @MilanMuso, @StephenORahilly et al. (@Cambridge_Uni) The authors provide evidence in humans and mice that impaired LXRα signalling is hepatotoxic, despite its potent lipogenic actions. nature.com/articles/s4225…
REVIEW | Jens Juul Holst (@Metabolcenter) Dr. Holst reflects on the development of #GLP1 based drugs for the therapy of #obesity, discussing #physiological, #pharmacological and #clinical considerations related to their use.💉👥 nature.com/articles/s4225…
In diabetes, the capillary microvessels can become obstructed, leading to damage to neurons and cognitive deficits. A new mechanism elucidated involving interleukin-10 may help explain why @NatMetabolism nature.com/articles/s4225… @CraigEdBrown @MyUVic nature.com/articles/s4225……
Studies in mice reveal that IL-10 signalling has an unexpected pathogenic role in cerebral microcirculatory defects and cognitive impairment associated with type 1 #diabetes #T1D @NatMetabolism nature.com/articles/s4225…
RESEARCH | R Nakai, T Yokota, J Brestoff et al. (Osaka Univ, JPN; @washu_pathology) Administration of exogenous #mitochondria 💉or mitochondrial transfer from wild-type mice improves morbidity and mortality in a mouse model of #Leighsyndrome🐁 nature.com/articles/s4225…
#NatMetabPicks | In @CellCellPress, led by H Zhao, Z Liu, H Chen & B Zhou (ShanghaiTech University, CN): Functional diversity of #senescent p16(Ink4a+) cells and insights into developing cell-type-specific #senolytic #therapies in the future.🧫🧪 cell.com/cell/fulltext/…
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Cell Metabolism
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Cell Reports
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Molecular Cell
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bioRxiv
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Nature Reviews Cancer
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Developmental Cell
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