Thor C. Møller
@tcmollerSenior Scientist at Novo Nordisk. Views and opinions are my own.
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75 years of research on human diseases in 1 minute
EDITOR'S CHOICE: In contrast to canonical arrestin-mediated GPCR internalization via clathrin, an increasing number of GPCRs are found to be endocytosed via alternate pathways and the process appears more diverse than previously recognized. bit.ly/3cC2MH0
Nature article doi.org/10.1038/s41586… showing #GPCR isoform signalling bias, and a GPCRdb resource gpcrdb.org/protein/isofor…. Another landmark study from @m_madan_babu group and great teamwork by Marti-Solano et al. Thanks to @Lundbeckfonden and @novonordiskfond
Please RT! WE ARE HIRING: Postdoc Positions at Scripps Research. Receptor biology, GPCRs, genetic and proteomic screens, synaptic connectivity, mouse models, optical sensors, signaling assemblies, drug discovery. #GPCR scripps.edu/martemyanov
VERY EXCITED TO SHARE THIS @biorxivpreprint where we reveal the identity of the long-sought GHB high-affinity binding site to be CaMKIIa. biorxiv.org/content/10.110… See thread 👇 for an amazing journey of excellent collaborative and scientific effort. 1/6
Illuminating the allosteric modulation of the calcium-sensing receptor pnas.org/content/early/…
Funny story. Kathy Giacomini pitched us a project on inactive ingredients via her @US_FDA @ucstanfordcersi I thought she was joking. Spoiler alert: we demonstrate no toxicity; most excipients undoubtedly are safe, even inert. science.sciencemag.org/content/369/65…
Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function - a new @PharmRevJournal @IUPHAR review pharmrev.aspetjournals.org/content/72/3/5…
GPCRdb is expanding with a postdoc in bioinformatics, data science or database programming. jobportal.ku.dk/videnskabelige… #gpcr #drugdiscovery #bioinformatics #DataScience
Caveolins are essential for formation of caveolae. Increasing evidence indicates that caveolins also have numerous functions that are independent of caveolae. Non-caveolar caveolins – duties outside the caves jcs.biologists.org/content/133/9/…
We are delighted to announce the @COMPARE_UoBUoN ECR-focussed GPCR Symposium here in Nottingham, April 22nd. We have a great line-up of speakers and it's free to attend! What's not to love? Sign up for free here: bit.ly/2wMbjWI
Analyzing kinetic signaling data for G-protein-coupled receptors biorxiv.org/content/10.110…
Single cell RNAseq of mGluRs in mouse cortex showing high degree of co-expression of heteromerization prone mGluRs sciencedirect.com/science/articl…
Interessant analyse fra @regeringDK ekspertgruppe om #COVID19dk genåbning: #dkuni er sektor med laveste smitterisiko sammenholdt med betydning for beskæftigelsen #dkpol #uddpol fm.dk/media/17914/ra…
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Xavier Leroy, PhD, EMBA
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