Christoph Klenk
@ChristophKlenkMD PhD @UZH_science | interests: #GPCRs, molecular #pharmacology, #endocrinology, #DrugDiscovery, #ProteinEngineering, #DirectedEvolution
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If you have a master's degree or will be finished soon and you like to study GPCRs in a PhD project, then consider this: tinyurl.com/y6za8df6 There is still time to apply! Please RT @ErnestNetwork @GPCRzoominar @cool7TMs @ONCORNET1 #PhD #PhDposition
Interested in GPCRs and Toll-like receptors? You want to combine computational approaches and pharmacological experiments? Then have a look at framework topic 3! #PhD #PhDposition There is more than a week left to apply: tinyurl.com/y6za8df6
Just a happy bunch of colleagues from all over the world enjoining science and nature @GordonConf MolPharm
Super interesting paper! Great to see that our in vitro findings on proteolytic #PTH1R ECD cleavage are indeed physiologically relevant. elifesciences.org/articles/82142
Already a few days out, but I am still happy that our new system for directed evolution of #GPCRs in mammalian cells has finally been published in @NatureComms Great teamwork of @UZH_Science and @Vaccinex! nature.com/articles/s4146…
A system for expressing and evolving G protein-coupled receptors in mammalian cells @ChristophKlenk @UZH_science @Vaccinex nature.com/articles/s4146… #BiotechNatureComms
❗We are looking for #postdoc and #PhD students in #bioinformatics #datascience to work on inter-species molecular interactions (#GPCR, #alphafold2, #machinelearning) fundet by @Carlsbergfondet 🙏 . More info in the links below👇 or contact me directly! Please RT. #postdocjobs
This guideline for a standardized way to report ligand bias will help to precisely describe biased signaling and make the data usable for data-driven approaches. It also defines and recommend terms to be used when report biased ligands. #GPCR
Finally, much-needed community guidelines for #GPCR ligand bias! Can better experiment design and reporting clarify complex pharmacology towards #drugdiscovery with fewer adverse effects? doi.org/10.1111/bph.15…
Structural basis for the activation and ligand recognition of the human oxytocin receptor biorxiv.org/cgi/content/sh… #bioRxiv
We are delighted to announce that the 6th ERNEST meeting will be held online, 28th – 31st March 2022! Join us to continue our efforts to build a comprehensive map of GPCR signal transduction. ernestmeeting.com #ernest6 #GPCRsig #signallingmap
Finally out @FrontEndocrinol! Check out our recent discovery that protease cleaveage modulates #signaling selectivity of #parathyroid hormone 1 receptor . Yet another mechanism for biased signaling of #GPCRs. frontiersin.org/articles/10.33…
Excited to share our paper on the #crystalstructure of the alpha1B-#adrenergic #GPCR. Our findings on ligand subtype selectivity will hopefully help design safer #aminergic drugs to treat neurological and cardiovascular disorders nature.com/articles/s4146…
I am beyond happy that I can share our manuscript with the community! #GPCR+#RAMP interplay from a collaborative effort of Lohse lab/Receptor signaling lab @MDC_Berlin with @HSchihada, Scheerer lab @ChariteBerlin, Martin J.Lohse, and Isabella Maiellaro. biorxiv.org/content/10.110…
We are excited to announce positive topline results from the global Phase 2 trial of our pan-variant DARPin antiviral candidate for #COVID19 patients. bit.ly/3tcwRa1 $MOLN $NVS #JPM22
Happy to share that we have solved the 💎structure of the alpha1B #adrenergic receptor, a long-awaited missing piece to understand ligand subtype selectivity. The related paper with pharmacol data will be out soon. Our findings will hopefully help design safer #aminergic drugs💊
new release2 7B6W: Crystal structure of the human alpha1B adrenergic receptor in complex with inverse agonist (+)-cyclazosin Plueckthun lab.
new release4 Human Neurokinin 1 receptor (NK1R) substance P... 7P00: Gq chimera (mGsqi) complex 7P02: Gs complex "Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features." Pluckthun lab. Sci. Adv.
Ho ho ho! Here is our recently published review on structure-based virtual screening for GPCR ligands. Thanks to @FlavioBallante, @Chris_de_Graaf, Stefanie Kampen, Albert Kooistra, and @ErnestNetwork pharmrev.aspetjournals.org/content/pharmr…
Structures of neurokinin 1 receptor in complex with Gq and Gs proteins reveal substance P binding mode and unique activation features science.org/doi/10.1126/sc…
Exited to share our latest work on #neurotensin 1 receptor #GPCR. New crystal structures in complex with full, partial and inverse agonists as well as in the apo state enabled by a novel #DARPin xtal-chaperone. Full story: advances.sciencemag.org/content/7/5/ea…
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