Christina Metoikidou
@mt_christinPostdoctoral Researcher at @NKI_nl | previously at @institut_curie 👩🏻🔬 | 👩🏻💻 #cancerimmunology
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Our big story on the importance of "stripy" T cells in antigen response, which started as a MSc Thesis 6 years ago, has finally made its way out in @ScienceMagazine! 🤩 Massive congrats to @BenHale95 & thanks to all collaborators particularly @LabOxenius & @blutspendesrk 🥰
Out now @ScienceMagazine: @BenHalePhD, @BerendSnijder & colleagues report that the internal architecture of T cells at the moment they are activated can influence their fate in response to antigen. 🔗science.org/doi/10.1126/sc…
Two exciting studies out in @Nature show that high tumor PGE2 limits IL-2 sensing and antitumor function in TIL. Disrupting this axis can potently enhance antitumor responses. Nice work @CoukosGeorge @JBoettcherLab and teams! nature.com/articles/s4158… nature.com/articles/s4158…
Now online in @CD_AACR: CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T cell Pool doi.org/10.1158/2159-8… @KapteinPaulien @Thommen_ds @NKI_nl
Don't miss the 1st International Symposium of Institut Curie, bringing together researchers from all walks of science such as @mt_christin, postdoctoral researcher at @NKI_nl, who will give a talk on intratumoral heterogeneity in luminal #breastcancer. ➡️ curiesymposium.fr/registration
📆 Les 15, 16 et 17 mai prochains, l'Institut Curie vous donne rendez-vous au cœur de Paris dans un cadre historique et prestigieux, pour la 1ère édition de son Symposium International "From Basic Science to Cancer Research". Pour en savoir plus ↘️ curie.fr/actualite/even…
Adding spatial information to adaptive receptor sequencing could be a game changer in terms of understanding immune responses to infections, autoimmune diseases and cancer science.org/doi/10.1126/sc…
Really happy to see this beautiful study out, unveiling TEs distinct expression patterns across the T-cell exhaustion axis and upon ICB. Glad to have contributed to this work! Congrats to all authors and specially to @pe_bonte, Christel Goudot and Sebastian Amigorena 🎉
Really happy to share my PhD work recently published in @SciImmunology in which we study the impact of T cell exhaustion on transposable elements (TEs) and explore their potential as biomarkers in #cancer and #immunotherapy scim.ag/4BA #ScienceImmunologyResearch 🧵⬇️
CD8+ T cells in the cancer-immunity cycle: CD8+ T cells are “end effectors” of cancer immunity. Wherry, Kaech, Giles, & Globig review the current understanding of CD8+ T cell differentiation and function in cancer, discussing recent advances within a four-signal framework that…
Nature research paper: The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion go.nature.com/452R3ul
I’m delighted to share our @NatureCancer paper by Anne Kraemer et al. nature.com/articles/s4301… Our objective was to investigate whether there are substantial differences in the antigenic landscape presented in tumors that are T cell inflamed versus those that are non-inflamed.
Seventy years on from the discovery of the structure of DNA, controversy still surrounds two central points: how much credit Rosalind Franklin deserved, and the degree to which she was denied it nature.com/articles/d4158…
A 2021 @institut_curie @psl_univ study involving patients with lung #cancer defined the origins and organization of tumor-infiltrating killer T cells. 📄: scim.ag/2l2
Excited to share that our work on regional T cell clonal responses to immune checkpoint blockade is out now! Very grateful to @AndrewChowMDPhD, Matthew Hellmann, @Satpathology, and all other co-authors for this wonderful collaboration. Check it out here! authors.elsevier.com/c/1gqic_Ywcvmm…
Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! @Nature nature.com/articles/s4158…
Exciting to see our work out @NatImmunol nature.com/articles/s4159… A real team effort with @KatieEYost Sunnie Hsiung @HowardYChang @FW14B_Red5 @Satpathology & many others.
Check out the newest work published @Nature from our lab by Masao Hashimoto showing that the combination of IL2 and PD1 blockade modifies the CD8 T cell exhaustion program. 1/🧵 nature.com/articles/s4158…
NEW ONLINE: extracellular vesicle-mediated transfer of telomeres from antigen-presenting cells to T cells enables chromosome elongation, protection against replicative senescence and long-term immune defence. PDF: rdcu.be/cVGOX nature.com/articles/s4155…
Very happy to share our latest publication, fresh out in @Nature, defining stem-like #TPEX cells, crucial for maintaining T cell responses to chronic viral infections and fueling therapeutic immune reinvigoration during checkpoint inhibition: nature.com/articles/s4158…
So happy to attend all the great talks at #irci2022 and share my data! Thank you for the opportunity & the great discussions ☺️ @CIRI_Lyon @crcl
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