Evan Weber
@EvanWeberPhDAssistant Professor @PennMedicine @ChildrensPhila | CAR T cells, immunotherapy, epigenomics, T cell exhaustion | https://t.co/aRpyzfCH0r
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Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs? We answer this in our lab’s first paper in @Nature led by @alexdoan96 @kpmueller1 @andy_yhchen 1/ nature.com/articles/s4158…
WELL-DESERVED KAT! BRAVO! 👏👩🏻🔬
I'm honored to share that I have been awarded an Irvington Postdoctoral Fellowship from @CancerResearch! This funding will support my ongoing CAR T cell therapy research with @EvanWeberPhD at @ChildrensPhila 1/
Excited to share our recent manuscript out at @Nature . @piraner and @majo__duran from @roybal_lab and @Mohamad_Abedi and @AdamChazin in David Baker's lab engineered synthetic receptors that sense natural and designer soluble cues. nature.com/articles/s4158…
1/ This is the next chapter of a story about courageous patients and their families, of multidisciplinary teamwork, and hard-fought steps forward to effective therapy for #DIPG #DMG, a universally lethal cancer of the brain and spinal cord. 🧵nature.com/articles/s4158…
In @CellCellPress, I share a major conceptual challenge for biology in the next decade, inspired by Crick’s Central Dogma: understanding information flow in the cell, the smallest indivisible unit of life bit.ly/4hQMmva
I've been on a Twitter moratorium for the last week given the.. news, but I'm happy to announce a new story from our group @NatImmunol describing a metabolic sensitivity of exhausted T cells to lactic acid in tumors! 1/ nature.com/articles/s4159…
Published today @NatureBiotech: @CarlHJune and I reveal how CAR T cells are finally tackling solid tumors! @PennPPA @PennMDForum nature.com/articles/s4158…
Happy to share our new work describing DESynR genes! The evolution of new human protein-coding genes relies on repurposing protein domains from ancestral genes, rather than de novo sequence creation. New genes evolved from old parts, and while we have methods that enable…
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. Today we report in @Nature that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ nature.com/articles/s4158…
This 👇🏻
I'm honored to share that I have been awarded an Irvington Postdoctoral Fellowship from @CancerResearch! This funding will support my ongoing CAR T cell therapy research with @EvanWeberPhD at @ChildrensPhila 1/
Cell Therapy Keystone 2025 is coming! If you're interested in cell engineering, immunotherapy, cancer or autoimmunity (!) this meeting is for you! Join us in Banff for a fantastic symposium this March. Abstract deadline 12/9! @lab_rezvani keystonesymposia.org/conferences/co…
One of the most exciting advances in medicine has been the use of engineered T cells (CAR-T) to achieve 1-shot durable treatment (possible cure) of some autoimmune diseases. Here's a new review @ScienceTM, with over 50 ongoing clinical trials! science.org/doi/10.1126/sc… @JewellBioE
There is still about a month to apply to our faculty position in #immunology and #immunoengineering @MITdeptofBE! We look forward to reading your applications be.mit.edu/about/open-fac…
Join us @MITdeptofBE! We are searching for a tenure-track faculty colleague at the interface of #immunology and #biologicalengineering. Happy to answer questions about the BE department and junior faculty life at MIT (both great). Please share widely! be.mit.edu/about/open-fac…
Still time to submit abstracts to @sitcancer's upcoming Spring Scientific focused on solid tumor #celltherapy. We have built in podium presentations for selected abstracts in every session and an amazing line up of confirmed speakers from around the world. Join us in San Diego!
The 2025 Spring Scientific schedule is available for viewing! Join #SITC at the Cellular Therapy for Solid #Tumors program on March 12–14 in San Diego, CA & Virtually. To view the 2025 schedule, visit: go.sitcancer.org/3BwQ4cP #SITCquestfor100 #Cancer #Cure #IO #ImmunoOncology
Our new study published today @Nature uncovers that Transgelin 2 preserves T cell lipid metabolism and anti-tumor activity. Transgelin 2 is silenced in dysfunctional TILs, and restoring its expression enhances CAR-T cell therapy in #OvarianCancer 👇nature.com/articles/s4158…
Check out our latest paper “Differentiation fate of a stem-like CD4 T cell control immunity to cancer”, led by @Maria_Carden1 now live @Nature tinyurl.com/33d24k89 . This work examines how CD4 T cell differentiation dictates the outcome of the cancer response. Thread below
It took me years to understand this principle. Curate the data to make your talk’s take-home message as clear as possible. Data quality > quantity
Half the work of preparing a science talk is deciding what you don’t say - to avoid distracting the audience.
Super cool study, congrats!
Thrilled to announce our latest publication in @ScienceMagazine describing a reverse-translation study that defines the core regulators of T cell stemness that can be exploited to improve immunotherapy! @TaeGunKang2 @StJudeResearch @SU2C @VAInstitute science.org/doi/10.1126/sc…
I am very pleased to announce the work I did as a graduate student in the labs of Crystal Mackall and Everett Meyer has been published in Nature Communications, open access! nature.com/articles/s4146…
Many thanks to @NIH_CommonFund @theNCI for this honor and @CHOP_Research @CHOPCancerCntr @PennMedicine for their continued support! We look forward to taking epigenetic reprogramming to the next level to improve CAR T cell fitness and efficacy.
Congrats to @ChildrensPhila's Dr. Evan Weber, recipient of the @NIHDirector's New Innovator Award! Dr. Weber will pursue a novel approach to reprogram T cells with enhanced tumor killing function, paving the way for more efficacious #cancer therapeutics. @CHOPCancerCntr
Thrilled to share our back-to-back two Nature @Nature papers on the unexpected role of type 2 immunity against cancer. We found that interleukin 4 (Fc–IL-4), a type 2 cytokine, reinvigorates exhausted T cells to potentiate anticancer immunotherapy w/ @YugangGUO2 @RongFan8(1/11)
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