Ahmad Jomaa
@jomaa_labAssistant Professor at the University of Virginia, Biochemist, Molecular and Structural Biologist, Husband, Father, Traveller #cryoem #ribosome #rna
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Happy to share our little discovery with @SimoneMattei19 team on how ribosomes hibernate upside down on mitochondria during cellular stress is now out @NatureComms! A collaboration between @medicineUVA, @EMBL, @EmblImaging, MEMC. Congrats to all authors! nature.com/articles/s4146…
Actinobacteria appear to possess a species-specific ribosome hibernation factor, found in Mycobacteria, that binds to the nascent tunnel of dormant ribosomes. More in this exciting study by Ojha and Agrawal lab: biorxiv.org/content/10.110…
Double whammy! 🧬 Our latest collaboration with the Zaher/Beckmann/Inada labs reveals how Mbf1/EDF1 senses ribosome collisions to promote Gcn2 activation, allowing optimal induction of eIF2α phosphorylation and de-repression of GCN4 translation. cell.com/molecular-cell…
Happy to introduce DeFrND: designer peptide scaffolds to enable detergent-free reconstitution of membrane proteins with native lipids into nanodiscs for biochemical and structural studies. Let me know if you would like to try it. biorxiv.org/content/10.110…
Excited to share the final piece of my postdoctoral work (with @benny_ry) in the @Freudlab, where we determine the kinetic and structural basis of gap-filling DNA synthesis in the nucleosome by Pol β. biorxiv.org/content/10.110…
Excited to share our latest work in @NatureComms! We've captured an AAA proteolytic machine in action, right as it poised to unfold its substrate for degradation—a first-ever glimpse into this long-sought, elusive step in AAA proteolysis! Enjoy! rdcu.be/dZzRR
Check out our new preprint on plant🌱mitoribosome! We captured it in action, translating mRNA, and combining cryo-EM and Nanopore sequencing, identified key rRNA modifications. Plus we delve into a late-stage maturation step of the small subunit. 📖:biorxiv.org/content/10.110…
@3DRNA_CryoEM: Cryo-EM structure of raiA ncRNA from Clostridium reveals a new RNA 3D fold sciencedirect.com/science/articl… @JMolBiol Thanks @SOLARIS_science for the great microscope facility. 3D model illustration made with @proteinimaging
Collaborative work of @slavicaPD, @Hashemyaser4, Jovanovic Lab and @DjuranovicLab - a new method to isolate ribosomes and translational material in minutes. We show multiple usage of our RAPPL method in biochemical and structural assays with ribosomes. Please be free to contact…
Our timely contribution to the growing body of YebC2/TACO1 literature 🤩! YebC2 is a third factor that prevents ribosome stalling at prolines. Associates with 70S and important for fitness in absence of EF-P and YfmR. biorxiv.org/content/10.110…
1. Check out our MS just out! Amazing Mauricio Aguilar developed a new ML pipeline that identifies ribosome pausing sites as an Anomaly Detection problem to overcome spurious signals that arise when analyzing RiboSeq data. science.org/doi/10.1126/sc…
What happens at the very first moment when sperm & egg meet? We discovered a conserved trimeric ‘key’ on vertebrate sperm that binds to divergent egg proteins. Amazing work jointly lead by @deneke_v & Andreas Blaha @PauliGroup cell.com/cell/fulltext/…
The life of each one of us began when a sperm and an egg came together. But what actually happens at a molecular level? Our latest work @PauliGroup @CellPress reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/8) cell.com/cell/fulltext/…
Now out in peer-reviewed format at @nchembio …rdcu.be/dXhoi
Our preprint reporting the structure and mechanism of the natural product translation inhibitors paenilamicins is out…completely novel binding site on the ribosome! dlvr.it/T7CNnf…great collaboration with @Suessmuth_Lab @shuramankin
A massive team effort, “Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and respiration in mycobacteria.” Cryo-EM methods AND fundamental insight into mycobacterial metabolism, which is a target for TB drugs! 🧵 biorxiv.org/content/10.110…
Ribosomes hibernate on mitochondria during cellular stress: nature.com/articles/s4146…
Our latest work on structures of translation initiation complexes trapped by natural product inhibitors kasugamycin, edeine and GE81112 is out in the Biorxiv…biorxiv.org/content/10.110…
ncAAs can endow proteins with new activities, but their incorporation efficiencies during translation can be poor. Today in @NatureBiotech, we report that altering mRNA codon usage can improve incorporation efficiency, yielding proteins with up to 3 ncAAs! nature.com/articles/s4158…
Now on @biorxivpreprint - Temperature Sensitive Glutamate Gating of AMPA-subtype iGluRs 🧠🔥❄️🔬 In this preprint, we reveal how glutamate gating of iGluRs is unique from PAM-activated states (!!!), and how temperature effects glutamate gating. biorxiv.org/content/10.110…
1/8 ❄️🔬Excited to share our latest work published in @NatureComms! Led by @kaitlyn_m_abe and in colab with @GrantCryoEMLab, we've discovered a simple, cost-effective way to mitigate sample damage at the air-water interface during grid preparation. #CryoEM rdcu.be/dSWfn
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