LgDolce
@LgDolcePostdoc at EMBL Grenoble | RNA modifications | Cryo-EM
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I‘m happy to share our work on laser flash melting to overcome preferred orientation in cryo-EM samples! 🥳❄️🔬 More infos on the underlying mechanism of particle redistribution and the use for preferred orientation issues in the 🧵 or here: biorxiv.org/content/10.110…
A second period with the HelD wrestler: it physically links #RNA polymerase recycling and #transcription initiation. rdcu.be/dWukr @IOCBPrague @IBT_CAS @NIVBcz
One of the main challenges of contemporary medicine is posed by the resistance of pathogens to antibiotics. An important step in countering it has now been made by @tm_kouba and colleagues from @IOCBPrague, in collaboration with researchers led by Libor Krásný from the Institute…
Happy to share our work on Saccharolobus solfataricus translation initiation biorxiv.org/content/10.110…
In its final form out today: The complex structure of human tRNA methyltransferase METTL6 in complex with a fully modified serine tRNA and seryl-tRNA synthetase (SerRS). nature.com/articles/s4159…. All maps, models and micrographs are out as well! Some highlights:
The Kowalinski Group has shown that a tRNA-modifying enzyme selects a specific tRNA through cooperation with a tRNA synthetase, a highly abundant enzyme that’s extremely specific towards certain tRNAs – a previously unknown mechanism. Check the link to learn more!👇
To build proteins, the cell uses over 400 almost identical, yet different types of tRNA molecules. How does it distinguish them? EMBL Grenoble researchers have discovered that this happens through a previously unheard-of cooperation between two enzymes. embl.org/news/science-t…
To build proteins, the cell uses over 400 almost identical, yet different types of tRNA molecules. How does it distinguish them? EMBL Grenoble researchers have discovered that this happens through a previously unheard-of cooperation between two enzymes. embl.org/news/science-t…
@EMBLGrenoble is looking for a new Group Leader. Join the crew! embl.org/jobs/position/…
I am delighted to share our latest paper on the Integrator complex assembly and association with transcription factors. Great work by @MichalRazew, Angelique Fraudeau, @MorPfl and Romain Linares @embl @EMBLGrenoble authors.elsevier.com/sd/article/S10…
Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/…
+++ new preprint alert +++ We reveal the architecture of the #trypanosomatid RNA cap-binding complex (CBC) and probe its SL RNA binding properties. Does it bind the uniquely modified cap4 structure? --> read our preprint: biorxiv.org/content/10.110… #RNA #RNAcap #NTDs #cryoEM
U5 snRNP is one of the key building blocks of the spliceosome, but how it is assembled and recycled remains unknown. Check out our latest paper to find out more about this process: nature.com/articles/s4159… #RNP #splicing #cryoEM @EMBLGrenoble @ERC_Research
How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. nature.com/articles/s4158… @BoXia7
Would you like to gain a comprehensive overview of the methods used to study the structure of macromolecular complexes? 🧬 Then use your chance and apply for #EMBOMacromolecular by 10 March! 💻 s.embl.org/mmo24-01 🌍 EMBL Grenoble, France 📆 1 – 8 June During this @EMBO…
The Cusack (EMBL) & Kadlec (IBS) groups share in @CellReports how different kinds of Pol II transcripts (such as mRNA or snRNA) are directed to the appropriate processing pathway or degraded if they are aberrant in some way. [1/3] cell.com/cell-reports/f…
Amazing opportunity with a fantastic mentor!
We are advertising a (potentially) funded PhD project on mathematical modelling of malaria @aberdeenuni, where research questions can be tailored to the student’s interests. Deadline: 18th March 2024 Details can be found in the link below:
CryoCycle your grids! Plunge vitrify & reuse clipped cryoEM grids. We show vitrified proteins & cells (thin areas), offering $10k+/yr in savings. Added benefits: simpler clipping, less grid damage, no frozen fingers, & no need for commercial plungers. biorxiv.org/content/10.110…
Excited to share my final PostDoc work! Introducing MagIC-cryo-EM🪄 & DuSTER🧹, these methods reduce cryo-EM sample requirements (0.0005 mg/mL), enabling ALL biologists to explore the structural basis of diverse biological events! BioRxiv: biorxiv.org/content/10.110…
EasyGrid: A versatile platform for automated cryo-EM sample preparation and quality control biorxiv.org/cgi/content/sh… #biorxiv_molbio
We have received a lot of requests for help with making streptavidin affinity grids. We are happy to finally share our protocol for robust in-house fabrication of streptavidin affinity grids. Stay tuned for the accompanying video that is coming soon! app.jove.com/t/66197/strept…
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