Geordi Frere
@geordifrereFind me on 🦋 at @geordifrere #eXodus #ChemeXodus | Postdoc in the @GygiLab @HarvardCellBio | PhD @ChemUofT (#ProsserLab & @GunningLabUofT) | Rugby 🏉 & D&D 🎲
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If you haven't seen a 13C multiplet before, they are quite a sight to behold...
Scalable Thiol Reactivity Profiling Identifies Azetidinyl Oxadiazoles as Cysteine-Targeting Electrophiles | Journal of the American Chemical Society @scrippsresearch #Thiol #Reactivity #Profiling #Azetidinyl #Oxazolidinones #Cysteine #Electrophiles pubs.acs.org/doi/10.1021/ja…
Best safe alternative to NaH/DMF for alkylations? @SafeChem79 @BagPhos
Finally, RADICAL CROSS COUPLING without the exogenous REDOX. We disclose in @ChemRxiv (chemrxiv.org/engage/chemrxi…) a broadly general platform for achieving transformations that normally required excess metallic or chemical reducing agents or photochemical setups (and their…
Very nice paper in Science, showing that N-glycosylation can also function as a degradation signal, similar to Ubiq: science.org/doi/10.1126/sc…. Glad to see the authors used our #FragPipe/#MSFragger-Glyco “Glyco-N-LFQ” workflow for quantitative glycoproteomics data analysis.
Agreed! That's why I wrote ggpubfigs, a ggplot2 extension that *only colorblind-friendly color palettes. Easily make your figures colorblind-friendly with ggpubfigs! x.com/NKWhiteman/sta…
A reminder that your search committee chair, grant proposal reviewers, and manuscript reviewers might be among the 1/12 XY or 1/200 XX who can’t see what you think is obvious in your figures because they have a color vision deficiency. Adobe tools, many papers on the topic, etc.
How do you keep up with the newest papers in your field? @ResearcherApp is perfect for this, but with the announcement of their closure I'm looking for other options. @R_Discovery seems promising, but it doesn't sort by date and gives me a bunch of papers from 2-5 years ago. 😢
Absolutely devastated that @ResearcherApp is closing down!! 😱 Researcher fundamentally changed the way I engage with the scientific literature. Does anyone know any good alternatives that let you stay up-to-date with the literature using keywords and followed authors/journals??
Really proud of this perspective with @CarlosMYruela in @JACS_Au discussing recent work on extended drug-target residence times within HDAC inhibitors! @ACSBioMed Enjoy! (1/n) #OpenAccess #CovalentInhibition #SmallMolecules #DrugDiscovery #ChemTwitter pubs.acs.org/doi/10.1021/ja…
Thrilled to share our new study in @nchembio describing the proteome-wide impacts of electrophile stress in the context of covalent fragments. Big congratulations to first authors Ashley Julio @AshleyJulio4 and Flowreen Shikwana @FShikwana ! 1/5 nature.com/articles/s4158…
please i need the pins like this #tweet to get me some pins
🎉 Ambeed Pin Challenge 🎉 Love our pins? Want to collect them? 🤩 Now’s your chance! How to join: 1️⃣ Repost this post. 2️⃣ Get 200 likes before 10/31/2024, and we’ll send you 20 random pins! 3️⃣ If you're one of the top 5 with the most likes by 10/31/2024, and you’ll score 30…
Arginine Accelerates Sulfur Fluoride Exchange and Phosphorus Fluoride Exchange Reactions between Proteins (Lei Wang and co-workers) @WangUCSF #openaccess onlinelibrary.wiley.com/doi/10.1002/an…
We often have a bias toward non-hydrogen atoms, forgetting the central role that hydrogens play in molecular recognition. Biotin has 16 non-hydrogens and 15 hydrogens. It is biotin’s hydrogen atoms that are mostly responsible for its impressive binding affinity.
🗞️ "Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by 19F–13C two-dimensional NMR" ⤵️ @UofT &+ With #NSERCsupport.
Excited to share our new paper in @rsc_chembio on improving resolution in fluorotryptophan protein NMR by expanding into the 13C dimension! We prepared & used a 13C-labelled F-Trp precursor to achieve unprecedented spectral resolution of a F-Trp-bearing protein by 2D 19F-13C NMR!
Open season on FOXA1! Our paper with the Cravatt group is out today in @MolecularCell Please check out the updated data, including a new discovery that FOXA1 ligands mirror the effects of a nearby prostate cancer mutation. authors.elsevier.com/a/1jxLO3vVUPRn… (1/2)
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