@GeorgeJSaunders Profile picture

George Saunders

@GeorgeJSaunders

Part time organic chemist, part time sports enthusiast. Alumni @ Warwick (PhD, Shipman lab) and Toronto (Postdoc, Yudin lab).

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George Saunders Reposted

This report documents one of the most exciting observations we have ever made. Meticulously carried out by Marty and @GeorgeJSaunders this @J_A_C_S work shows how metastable 3-10 motif can be stabilized and enriched at high T. Should be a useful scaffold. pubs.acs.org/doi/abs/10.102…

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Great to see this project out in its final form! We took a deep dive into the role of H-bonds in complex macrocyclic structures and found some interesting effects.

Identification of "Structural Pin" Interactions and their Significance for the Conformational Control of Macrocyclic Scaffolds (Andrei K. Yudin and co-workers) @andrei_yudin @GeorgeJSaunders #OpenAccess onlinelibrary.wiley.com/doi/10.1002/an…



Proud to share this paper from my PhD studies on azetidine modified cyclic peptides! This was a very fun project to work on with some really cool outcomes and applications

Synthesis and Functionalization of Azetidine-Containing Small Macrocyclic Peptides (Michael Shipman and co-workers) @GeorgeJSaunders, @RoesnerL, @warwickchem onlinelibrary.wiley.com/doi/10.1002/ch…



George Saunders Reposted

Here is our study aimed at understanding cell penetration of oxadiazole-containing macrocycles. These are very peculiar molecules. Indebted to ⁦@ChemKritzer⁩ and his lab’s wonderful CAPA system. ⁦@Sean_SJ_Huh⁩ and Nefeli led the investigation. pubs.rsc.org/en/content/art…


George Saunders Reposted

In this study, expertly spearheaded by ⁦@DiegoBenDiaz⁩ (now at Merck #MerckChemistry) we investigate the role of attractive non-covalent interactions in peptide macrocyclization ⁦@JOC_OLpubs.acs.org/doi/10.1021/ac…


George Saunders Reposted

With @Sean_SJ_Huh (our recent PhD!) and @GeorgeJSaunders we deployed the rarely used Cornforth rearrangement to remove an atom from a macrocycle. This @angew_chem paper studies the interplay between reactivity and uncommon conformational states. doi.org/10.1002/anie.2…

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George Saunders Reposted

Exciting news this Friday🎉 We’ve just published our second commentary piece by @andrei_yudin and @GeorgeJSaunders which provides additional viewpoints & contextualises earlier results from Alkane Kawamura, et al. You can read the Commentary here: rsc.li/3DCqqAT [1/2]

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George Saunders Reposted

Many factors affect cellular permeability of macrocycles. Together with ⁦@GeorgeJSaunders⁩ we consider the effect of heterocycles in this paper that just came out. As luck would have it, George is giving a poster on this advance at #APS2022 today. onlinelibrary.wiley.com/doi/abs/10.100…


George Saunders Reposted

Tim McTiernan, @DiegoBenDiaz, @GeorgeJSaunders, Fiona Sprang and I describe MCMs (macrocycle conformational maps) that visualize conformational changes taking place in large ring systems. @genentech and @NSERC supported this study. 1/6


George Saunders Reposted

Synthesis of α- and β-Carbolines by a Metalation/ Negishi Cross-Coupling/SNAr Reaction Sequence #RSCPosterLive #RSCOrg #RSCPoster

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George Saunders Reposted

Check out my #gidw2020 poster! 😁 P125 –Rh(I) and Rh(III) pincer complexes: (R,R)-Ph-pybox vs iPr-PNP. @Chaplinlab @SyslMeTimbers Happy to answer any questions, thanks to @CIC_ChemInst @DaltonTrans @cscinorgdiv @degruyter_phys for supporting this event.

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