George Saunders
@GeorgeJSaundersPart time organic chemist, part time sports enthusiast. Alumni @ Warwick (PhD, Shipman lab) and Toronto (Postdoc, Yudin lab).
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This report documents one of the most exciting observations we have ever made. Meticulously carried out by Marty and @GeorgeJSaunders this @J_A_C_S work shows how metastable 3-10 motif can be stabilized and enriched at high T. Should be a useful scaffold. pubs.acs.org/doi/abs/10.102…
Great to see this project out in its final form! We took a deep dive into the role of H-bonds in complex macrocyclic structures and found some interesting effects.
Identification of "Structural Pin" Interactions and their Significance for the Conformational Control of Macrocyclic Scaffolds (Andrei K. Yudin and co-workers) @andrei_yudin @GeorgeJSaunders #OpenAccess onlinelibrary.wiley.com/doi/10.1002/an…
Proud to share this paper from my PhD studies on azetidine modified cyclic peptides! This was a very fun project to work on with some really cool outcomes and applications
Synthesis and Functionalization of Azetidine-Containing Small Macrocyclic Peptides (Michael Shipman and co-workers) @GeorgeJSaunders, @RoesnerL, @warwickchem onlinelibrary.wiley.com/doi/10.1002/ch…
Here is our study aimed at understanding cell penetration of oxadiazole-containing macrocycles. These are very peculiar molecules. Indebted to @ChemKritzer and his lab’s wonderful CAPA system. @Sean_SJ_Huh and Nefeli led the investigation. pubs.rsc.org/en/content/art…
In this study, expertly spearheaded by @DiegoBenDiaz (now at Merck #MerckChemistry) we investigate the role of attractive non-covalent interactions in peptide macrocyclization @JOC_OL pubs.acs.org/doi/10.1021/ac…
With @Sean_SJ_Huh (our recent PhD!) and @GeorgeJSaunders we deployed the rarely used Cornforth rearrangement to remove an atom from a macrocycle. This @angew_chem paper studies the interplay between reactivity and uncommon conformational states. doi.org/10.1002/anie.2…
Exciting news this Friday🎉 We’ve just published our second commentary piece by @andrei_yudin and @GeorgeJSaunders which provides additional viewpoints & contextualises earlier results from Alkane Kawamura, et al. You can read the Commentary here: rsc.li/3DCqqAT [1/2]
Many factors affect cellular permeability of macrocycles. Together with @GeorgeJSaunders we consider the effect of heterocycles in this paper that just came out. As luck would have it, George is giving a poster on this advance at #APS2022 today. onlinelibrary.wiley.com/doi/abs/10.100…
Tim McTiernan, @DiegoBenDiaz, @GeorgeJSaunders, Fiona Sprang and I describe MCMs (macrocycle conformational maps) that visualize conformational changes taking place in large ring systems. @genentech and @NSERC supported this study. 1/6
Synthesis of α- and β-Carbolines by a Metalation/ Negishi Cross-Coupling/SNAr Reaction Sequence #RSCPosterLive #RSCOrg #RSCPoster
Check out my #gidw2020 poster! 😁 P125 –Rh(I) and Rh(III) pincer complexes: (R,R)-Ph-pybox vs iPr-PNP. @Chaplinlab @SyslMeTimbers Happy to answer any questions, thanks to @CIC_ChemInst @DaltonTrans @cscinorgdiv @degruyter_phys for supporting this event.
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