Zhang Shaoshi
@ZShaoshineuroscience, computational models | Computational Brain Imaging Group | Huge fan of Metroidvania and Edward Hopper.
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Milestone achieved! Our paper on biophysical modelling and E/I ratio estimation is now out on PNAS! pnas.org/doi/10.1073/pn… Check out our short summary on Kudos link.growkudos.com/1e9chg5dekgand and the thread below 🧵👇 @bart_larsen @valerieJsydnor @sattertt @bttyeo
1/11 Super excited to share our latest preprint! 📢 We estimate a putative marker of whole-cortex excitation/inhibition (E/I) ratio that indexes cortical maturation in youth! Leveraging a large-scale biophysically plausible model, we can estimate E/I ratio in-vivo! 🧵
Check out our version 1.0 of the sample size-scan time calculator. Any feedback is welcome and stay tuned for more updates to come! 👇
Here's a preliminary release of our calculator to explore sample size and scan time to maximize individual-level prediction accuracy: leonoqr.github.io/ORSP_Calculato… Let us know if anything is unclear or if there's bugs. Your feedback is welcome. If you find this calculator helpful for…
Check out the latest update on our study! We dive into the nuances of the tradeoff between scan time and sample size in BWAS analyses. A special thanks to all the coauthors who contributed their datasets to make this possible!
Super excited about our revised study! 4 more datasets showing robustness across fMRI sequences, racial groups, disorders, lifespan, phenotypic domains & resting/task FC: doi.org/10.1101/2024.0… @Leon_Oo1 @ZShaoshi @csabaorban broke the lab's record with a 76-page response!
Very excited to see ventral attention network playing a key role in cortical maturation, thanks to the beautiful work of Hao-Ming Dong @loic_lbc @ZShaoshi Leon Ooi @bttyeo @DanielMargulies @AvramHolmes @zuoxinian Congratulations!
Ventral attention network connectivity is linked to cortical maturation and cognitive ability in childhood, shown using multiple cross-culture longitudinal datasets nature.com/articles/s4159…
Ventral attention network connectivity is linked to cortical maturation and cognitive ability in childhood, shown using multiple cross-culture longitudinal datasets nature.com/articles/s4159…
👀 In-vivo whole-cortex marker of excitation-inhibition ratio indexes cortical maturation and cognitive ability in youth | bioRxiv biorxiv.org/content/10.110…
What drives fMRI signals to go up or down? Beyond conventional “neurovascular coupling”, our latest work @NatureComms reveals critical factors in the striatum by controlling and measuring key cell types and circuits across scales, modalities, and species: nature.com/articles/s4146…
Check out our new study discussing the balance between sample size and scan duration in BWAS. Led by the awesome @Leon_Oo1 and @csabaorban! "The returns of scan duration eventually diminish relative to sample size, which we explain with principled theoretical derivations." 👇
1/11 The poll has ended: 53% (scan time) vs 47% (sample size)! Here's our in-depth take on brain-wide association studies (with a 134-page supplement!): biorxiv.org/content/10.110… Led by @Leon_Oo1 @csabaorban, there are a few twists, so do read till the end! Our previous study ...
Super excited about this new preprint. Will do a thread on it later today.
MRI economics: Balancing sample size and scan duration in brain wide association studies biorxiv.org/cgi/content/sh… #biorxiv_neursci
could meta-matching be extended to structural MRI data? Yes! Please see our lab's latest meta-matching work by Naren👇
Translating phenotypic prediction models from big to small anatomical MRI data using meta-matching biorxiv.org/cgi/content/sh… #bioRxiv
Anybody else having problems with ABCD 5.0 release? Minimally processed data is missing for many children. Raw data is complete but docker to perform minimally processing is incomplete. We were told nothing will be fixed until summer 2024 & previous releases are not available...
'A critical period plasticity framework for the sensorimotor–association axis of cortical neurodevelopment' @TrendsNeuro Review by @Bart_Larsen, @valerieJsydnor, @ArielleKeller, @bttyeo & Ted Satterthwaite @sattertt cell.com/trends/neurosc…
this paper's nuts. for sentence classification on out-of-domain datasets, all neural (Transformer or not) approaches lose to good old kNN on representations generated by.... gzip aclanthology.org/2023.findings-…
How does the complex wiring of brain networks shape communication between neural elements? Check out our review in @NatRevNeurosci for the latest on brain network communication models! w/ @spornslab & @AndrewZalesky nature.com/articles/s4158… 🧵...
Very interesting and exciting new results!
1/11 Super excited to share our latest preprint! 📢 We estimate a putative marker of whole-cortex excitation/inhibition (E/I) ratio that indexes cortical maturation in youth! Leveraging a large-scale biophysically plausible model, we can estimate E/I ratio in-vivo! 🧵
Very excited about new study from our group!
1/11 Super excited to share our latest preprint! 📢 We estimate a putative marker of whole-cortex excitation/inhibition (E/I) ratio that indexes cortical maturation in youth! Leveraging a large-scale biophysically plausible model, we can estimate E/I ratio in-vivo! 🧵
Check out our recent preprint, co-led with @ZShaoshi, in which we use a biophysically plausible model to map developmental differences in the cortical E/I ratio in youth! An awesome and fun collab between the @bttyeo and @sattertt #PennLINC labs!
1/11 Super excited to share our latest preprint! 📢 We estimate a putative marker of whole-cortex excitation/inhibition (E/I) ratio that indexes cortical maturation in youth! Leveraging a large-scale biophysically plausible model, we can estimate E/I ratio in-vivo! 🧵
Exciting 🤩work from @ZShaoshi & @bttyeo in collab with @bart_larsen validates a neat approach to estimating cortical E/I ratios from fMRI data! Application to youth 🧠data reveals that E/I ratio development varies between sensorimotor and association cortex and impacts cognition
1/11 Super excited to share our latest preprint! 📢 We estimate a putative marker of whole-cortex excitation/inhibition (E/I) ratio that indexes cortical maturation in youth! Leveraging a large-scale biophysically plausible model, we can estimate E/I ratio in-vivo! 🧵
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