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uri alon

@UriAlonWeizmann

The Alon lab explores design principles of biological circuits, focusing on systems medicine, ageing and healthspan.

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Postdoc opportunity to work with Weizmann and Max Plank, superb funding. Enjoy the best of both worlds. weizmann.ac.il/sites/mpg-wis/


A classic essay Any jackass can trash a manuscript, but it takes good scholarship to create one PMID: 21357757


uri alon Reposted

@UriAlonWeizmann has a very interesting saturating repair model for aging, explained in his 2023 book. A simple SDE exhibits Gompertz-like mortality, and fits experimental data quite well. Sadly, most biologists are allergic to this type of thinking.

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Just did a group meeting of a PhD student in the cloud. It takes courage to say I'm stuck, confused, discouraged. This vulnerability elicited solidarity and support from the group, and a flood of new ideas and hope. It was gratifying for everyone.


uri alon Reposted

Peep this table of contents 👀@ArtirKel

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Johannes is a pioneer in systems endocrinology, writing here about type 2 diabetes.

What is the primary event in the pathogenesis of type 2 #diabetes – dysfunction of pancreatic beta cells or hypersecretion of #insulin? This question is still unsolved and may represent a chicken-and-egg problem. pubmed.ncbi.nlm.nih.gov/32894311/

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Warmly recommend, this fellowship for post docs gives you a community and great soft skills training.

Attention international postdocs: Applications for the Azrieli International Postdoctoral Fellowship are now being accepted and are due by May 9! The Azrieli International Postdoctoral Fellowship supports the best and brightest minds in their postdoctoral research in Israel,…

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Tertiary lymphoid structures are similar to germinal centers generated near a tumor with anti-tumor effects. Soon to come from our lab - math modelling of their genesis. This study tracks their formation over time in lung cancer.

We are very excited to share ‘An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structure’ published in @CellRepMed today (1/7) @press_cell cell.com/cell-reports-m…

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Immune cell and endothelial cell abundance in different tissues by deconvolution of many RNAseq samples.

The immune map of human body biorxiv.org/content/10.110…

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Who gets prediabetes and who doesn’t? New study quantifies the maximal insulin production capacity that beta cells can potentially reach in a given person based on blood tests. biorxiv.org/content/10.110…


uri alon Reposted

Alexei Navalny was asked what his message would be to people if he was killed. His response from the Academy Award winning documentary about him directed by @DanielRoher


uri alon Reposted

Elections NOW בחירות עכשיו 💪🇮🇱🇮🇱

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Just saw what my students put on the wall of the lab :)

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uri alon Reposted

CAR T cells to reverse - and even prevent - aging phenotypes! The CAR Ts target uPAR, which is upregulated in senescent cells. Treated mice see metabolic improvements & better exercise capacity, & this can work prophylactically, too: treat young mice, and the have better glucose…


uri alon Reposted

Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results nature.com/articles/s4159…


E. coli engineered to become stem cells that differentiate! We prevent take-over by mutant stem cells that only self renew - by linking differentiation to an essential function. A new way to engineer stable microbial communities. sciencedirect.com/science/articl…


uri alon Reposted

Saturday again, back in the streets... This time in Caesearia, close to his home, to remind him the people of Israel want #elections_now!!!

אתמול הגיע @MateAcademia_IL לקיסריה להזכיר לנתניהוז שהעם דורש בחירות עכשיו! לא נוותר עד שהסיוט הזה ייגמר!! תצטרפו אלינו! @shouval @sagy_yair @AterItai @tsamric @tschonberg

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