Jonathan Weissman's Lab
@JswLabJonathan S. Weissman's lab at the @WhiteheadInst/@MIT. Account run by lab members.
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excited to share COMET! A scalable CRISPR approach we (@carwils) developed to identify multidomain proteins that modulate transcription at specific endogenous genomic loci. @arcinstitute @ucsf doi.org/10.1101/2024.1…
There has been confusion over mitochondrial mutation detection, consensus variant calling, and lineage tracing in single cells. Here, we detail how ReDeeM addresses these challenges, improving detection of mtDNA mutations by 10-fold and lineage tracing. Led by @chenweng1991 and…
Just how impactful are large-scale perturbational data in single cell genomics? In the last two weeks, there have been *three* modeling/stats preprints with qualitatively different questions and insights for the same dataset generated by @josephmreplogle @JswLab (links below)
Excited to share the lab's collaboration with @NadigAjay @josephmreplogle and @Luke0connor: an expanding atlas of Perturb-seq datasets across multiple cell types
Check out our latest large-scale Perturb-seq on biorxiv! biorxiv.org/content/10.110… A new stat gen/GWAS-inspired analytic framework + large-scale screens in an expanded range of cell types Thanks @NadigAjay and @Luke0connor for involving us!
It’s been great working with @EdwinNNeumann and @TessaBertozzi for the past 2 years. Grateful I got to be part of such an impactful project and work with amazing people
Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0 science.org/doi/10.1126/sc…
"CHARMs are an elegant solution to the problem of silencing disease genes, and they have the potential to have an important position in the future of genetic medicines," @JswLab says. wi.mit.edu/news/charmed-c…
Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene. Our lab's collaboration with @JswLab's @EdwinNNeumann & @TessaBertozzi shows deep silencing of brain PrP Paper: science.org/doi/10.1126/sc… Blog: cureffi.org/2024/06/27/int…
Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0 science.org/doi/10.1126/sc…
Glad to have our work using natural barcode-based lineage tracing to decipher cell states and genealogies of human hematopoiesis out today in @Nature, led by @chenweng1991, a great collaboration with @bloodgenes doi.org/10.1038/s41586… Check out this terrific thread as well!
Very delighted to share our work Deciphering cell states and genealogies of human hematopoiesis online today in @Nature (Accelerated Preview version). It is a really great collaboration of Weissman lab @JswLab and Sankaran lab @bloodgenes doi.org/10.1038/s41586… 🧵(1/n)
Very excited to announce that I'll be starting a laboratory studying the biology of homeostasis as an assistant professor in the Department of Developmental Biology (@DevBioStanford) at @Stanford in July! allenlabstanford.org
Will is developing the world's best tools to dissect the cellular and tissue homeostasis. Don't miss this incredible opportunity to join him and inaugurate a new era of integrative physiology.
Very excited to announce that I'll be starting a laboratory studying the biology of homeostasis as an assistant professor in the Department of Developmental Biology (@DevBioStanford) at @Stanford in July! allenlabstanford.org
Excited to share my first paper from grad school out today in @MolecularCell! We systematically define biogenesis pathways for alpha-helical OMM proteins triaged by the NAC and TTC1 chaperone complexes for polytopic and signal-anchored proteins (1/2). cell.com/molecular-cell…
Excited to announce the Yang lab officially opens at @Columbia University. We are interested in developing innovative single cell recording technologies to study tumor evolution and cancer plasticity. We are hiring motivated postdocs & students, please RT dianyanglab.com
Super happy that our SARS-CoV-2 host factor story is out at @NatureComms doi.org/kx4x Preprint tweetorial 👇🏻 Updates since the first preprint 🧵👇🏻👇🏻
🚨 New #LoveVirology preprint: This paper has it all: single cells, COVID, CRISPR & Sunshine! We systematically characterize host factors of SARS-CoV-2 using Perturb-seq. Led by @sarasunshinebio, bringing together @JswLab, Joe DeRisi's lab & many others doi.org/10.1101/2022.0… 1/
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