Kyle G Daniels
@ScienceKyleAssistant Professor @Stanford University Genetics. Synthetic Biologist // Real Human 🧬 🔬 💻 🏳️🌈 🏊🏾♂️
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First Blood. Now that we have T cells and monocytes, the lab is officially open. Excited to engineer some new CAR-T and CAR-M tech. #newpi
Over the edge. Down the rabbit hole. Completely insane. Would not have believed this possible until right now. Completely independent of politics, this must be seen as unacceptable in 2024.
I am thrilled to announce Robert F. Kennedy Jr. as The United States Secretary of Health and Human Services (HHS). For too long, Americans have been crushed by the industrial food complex and drug companies who have engaged in deception, misinformation, and disinformation when it…
A highly innovative, potential breakthrough in synthetic biology: engineered receptor platform to activate specific cells based on their cell surface molecules, such as immune response to cancer nature.com/articles/s4158… @Nature @UCSF @KoleRoybal @roybal_lab @parkerici @piraner
#CARTcells for #DIPG #DMG clinical trial (1st arm) results are out today. Full Tweetorial coming, but first want to share the story of a patient whose #DIPG has disappeared for over 3 years. It is a milestone and moment of hope on a journey filled with so much grief. “There’s a…
Great talk by @PelkaLab @GladstoneInst on defining immune hubs in tumor microenvironment of human cancers to uncover new biology and biomarkers for ICB. #SITC2024
PhD applicants often ask about work-life balance. Reality check: it’s high-variance. This past Summer? Great balance, focused solely on research, had time for myself. This Fall? Madness. 7 days a week, working on weekends, two research projects, multiple reviews and interviews.
Happy to share our new work describing DESynR genes! The evolution of new human protein-coding genes relies on repurposing protein domains from ancestral genes, rather than de novo sequence creation. New genes evolved from old parts, and while we have methods that enable…
Combining simultaneous up-and-down gene regulation with machine learning model-guided cell engineering: PreciCE: Precision engineering of cell fates via data-driven multi-gene control of transcriptional networks biorxiv.org/content/10.110…
Thrilled that our work on the functional effects of EML4-ALK assemblies in cancer cells is now published in @NatureComms Herculean effort through 2.5+ years of peer review by @David_GonzMar and @LeeeRoth nature.com/articles/s4146…
So excited to share our latest on how oncogenes and drugs corrupt cell signal perception, feat. protein condensates, optogenetics, Erk pulses, and drug resistance -- something for everyone! Led by @David_GonzMar with huge assist from @LeeeRoth biorxiv.org/content/10.110…
We are proud of our high school student, Gabbie! She presented @BMESociety highlighting her work using EEG frequency bands & finding its associations with acute pain in sickle cell disease and healthy controls. She’s mentored directly by Joel and Liz. #BMES2024
🧵 Frustrated by synthetic gene circuit failure due to a simple change in the host cell growth? We’re excited to introduce a new approach: Stabilizing Synthetic Circuits with Liquid-Liquid Phase Separation (LLPS)! Check our latest preprint out here: biorxiv.org/content/10.110…
A super review of engineered T cells for cancer (CAR T and TILs) jamanetwork.com/journals/jama/… @JAMA_current @BrudnoN @MarcelaMaus @CSHinrichsMD
Please re-tweet: We are hiring! Assistant Professor in statistical genetics. Also, hiring a postdoc. Reach out to hear more. Also, if you’ll be at #ASHG24 #ASHG2024, we could meet. careers.ashg.org/jobs/20762543/…
Beautiful work by @Myers_lab on noncanonical signal transduction through Smoothened. I am happy we could contribute some data on receptor phosphorylation.
Excited to share our new preprint on the #Hedgehog pathway! We uncover how #Smoothened (SMO), a noncanonical #GPCR, binds & inhibits #PKA via an intrinsically disordered region, mimicking known GPCR/PKA signaling complexes despite minimal sequence similarity. #AlphaFold #IDR
APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2…
One of the most exciting advances in medicine has been the use of engineered T cells (CAR-T) to achieve 1-shot durable treatment (possible cure) of some autoimmune diseases. Here's a new review @ScienceTM, with over 50 ongoing clinical trials! science.org/doi/10.1126/sc… @JewellBioE
Wow! @KamalaHarris ‘s mother did some groundbreaking biochemical work on the estrogen receptor. Cytosolic and then nuclear after stimulation. Showing once again that immigrants are what makes us great. Check out the JBC paper: jbc.org/article/S0021-…
A two-step approach (step 1: activate B cells vs conserved epitope; step 2: boost w/ evolving virus) against HIV can reproducibly generate a potent plasma repertoire of broadly neutralizing antibodies in macaques @CellCellPress cell.com/cell/fulltext/…
The DelRosso Lab is starting @UCSF 1/2025 and is seeking applicants for a research postbac! We will be developing cutting edge high-throughput approaches to study the relationship between disordered protein interactions and transcription in human cells🔎 aprecruit.ucsf.edu/JPF05341
imagine you wake up every day in room-sized bed. you are gently lifted from the covers and dressed in warmest sweaters each morning. your favourite foods are brought to you. you have no bills, no job, no responsibilities. but you are a chihuahua, so you are blind with rage.
I love this story In 2003, it was reported that the stress response protein, MIC-1 (aka GDF-15), is raised in cancer patients with muscle wasting and weight loss (cachexia): In 2007, a monoclonal antibody that blocks MIC-1 (GDF-15) was found to boost appetite and weight gain in…
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