Rikesh Rajani
@RikeshRajaniSenior Research Fellow @UKDRI @ucl. Neuroscientist/dementia researcher. Living with #LongCovid. He/him.
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My latest research, now out @PLOSBiology! We show it's not just neurons that produce Aβ in Alzheimer's, oligodendrocytes produce Aβ too! Suppressing oligo Aβ in mice rescues neuronal dysfunction, hinting at new treatment avenues. A summary thread… 1/12 journals.plos.org/plosbiology/ar…
A dedicated issue of @ScienceTM on #LongCovid —Sex-specific differences, with perspective by @VirusesImmunity and @SilvaJ_C —Insights for therapies @AndreaCoxMDPhD —Deconvoluting "Osler's Web" @MichaelPelusoMD @DeeksSteven @DrMaureenHanson @SaydahSharon —+RECOVER Trial,…
♻️ RETWEET if you think that Clinically Vulnerable people (those at the most risk from Covid) were economically impacted by the pandemic. ♻️ The @covidinquiryuk rejected us for this module, leaving us with * NO VOICE * !!!! 1/
Please read this article if you’re a teacher or a parent. theconversation.com/it-would-cost-… via @ConversationEDU
Here's the conundrum: Most people won't stand up for people with Long Covid until they understand it. And most people don't understand Long Covid until they have it. And once you have Long Covid, you can't stand up and fight any more.
Delighted to see our recent paper on the role of oligodendrocytes in Alzheimer’s disease highlighted in @Alzforum! Also great to see consistent results across multiple research labs. Could stopping Abeta production in oligodendrocytes alone delay disease progression?
Oligodendrocytes may contribute up to a third of amyloid plaque, and they release soluble A42 that triggers neuronal hyperactivity. #alzheimersdisease @mpi_nat @ucl @uconnhealth ow.ly/jlvC50TEwEM
Oligodendrocytes may contribute up to a third of amyloid plaque, and they release soluble A42 that triggers neuronal hyperactivity. #alzheimersdisease @mpi_nat @ucl @uconnhealth ow.ly/jlvC50TEwEM
Appreciating the role of glia in #AlzheimersDisease: @LenaSpieth & Mikael Simons explore a #PLOSBiology study showing that #oligodendrocytes are an important source of the Aβ that impairs neuronal function. Primer: plos.io/4gvGuH1 Paper: plos.io/3zYNU56
Appreciating the role of glia in #AlzheimersDisease: @LenaSpieth & Mikael Simons explore a #PLOSBiology study showing that #oligodendrocytes are an important source of the Aβ that impairs neuronal function. Primer: plos.io/4gvGuH1 Paper: plos.io/3zYNU56
Appreciating the role of glia in #AlzheimersDisease: @LenaSpieth & Mikael Simons explore a #PLOSBiology study showing that #oligodendrocytes are an important source of the Aβ that impairs neuronal function. Primer: plos.io/4gvGuH1 Paper: plos.io/3zYNU56
One afternoon, Dr @marcaurelbusche & his team @UKDRI discovered something unexpected - oligodendrocytes not just neurons produce amyloid beta, a finding which has promise for future Alzheimer's disease treatments ➡️ bit.ly/4cZWhes #UCLDementia #WorldAlzheimersMonth
Important discovery: Multiple sclerosis patients exhibit reduced amyloid-beta accumulation, which is a key pathological feature of Alzheimer’s disease. I wonder if this could be explained by the loss of oligodendrocytes, which we recently found can produce and release…
Researchers from Washington University School of Medicine in St. Louis find that Alzheimer's disease is rare in people with multiple sclerosis with a "rate of amyloid-β plasma biomarker positivity...approximately half the rate in 300 non-MS controls." onlinelibrary.wiley.com/doi/10.1002/an…
Just published @Nature How fibrin drives brain inflammation in acute and #LongCovid and that a monoclonal antibody to fibrin protects against microglial activation nature.com/articles/s4158… @AkassoglouLab @GladstoneInst
#LongCOVID science, policy & research A new Review outlines the current state of evidence, impacts on patients, health systems, economies & global health metrics, and proposes a research & policy roadmap @zalaly @EricTopol @VirusesImmunity @LisaAMcCorkell nature.com/articles/s4159…
My latest research, now out @PLOSBiology! We show it's not just neurons that produce Aβ in Alzheimer's, oligodendrocytes produce Aβ too! Suppressing oligo Aβ in mice rescues neuronal dysfunction, hinting at new treatment avenues. A summary thread… 1/12 journals.plos.org/plosbiology/ar…
Today in @PLOSBiology, we reveal that in #Alzheimers, not only neurons but also oligodendrocytes produce #Abeta. Targeting #Abeta production in oligodendrocytes alone can rescue early neuronal dysfunction. Read the paper here: journals.plos.org/plosbiology/ar…
It has been widely accepted that amyloid-beta (Aβ) of Alzheimer's disease comes exclusively from neurons. Challenging that dogma is this new finding about the role of oligodendrocyte support cells journals.plos.org/plosbiology/ar… @PLOSBiology @marcaurelbusche @RikeshRajani @UKDRI
Challenging dogma on Alzheimer's disease and beta-amyloid production: the role of oligodendrocytes Now 2 reports journals.plos.org/plosbiology/ar… @PLOSBiology @marcaurelbusche @RikeshRajani @UKDRI @ucl nature.com/articles/s4159… @NatureNeuro @AOSasmita @KlausNave
Teorie inquietanti sull’Alzheimer: l’impatto sorprendente delle cellule di supporto cerebrale dlvr.it/TB1Np2
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