@macauleylab Profile picture

Shannon Macauley

@macauleylab

Associate Prof, PhD, wife, mom. Alzheimer’s disease | diabetes | brain metabolism | sleep | I ❤️ lactate | lysosomal storage diseases | she/her

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Pinned

Thrilled to be part of NPR’s Science Friday with @iraflatow this afternoon to discuss metabolism as a major player in the development of Alzheimer’s disease! @scifri @wakeforestmed @WakeGeriatrics @WakeADC sciencefriday.com/segments/alzhe…


Shannon Macauley Reposted

We need your help!! Please share your feedback on critical needs and priorities for AD, FTD, and related dementia research. grants.nih.gov/grants/guide/n…


A bit breezy but a fabulous reunion!

Reunited and it feels so good! #CCAD alumni take on #JupiterFL. 🌴

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🦋 is where it’s at. Great growth in science community in the last week!

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Shannon Macauley Reposted

Moved over to 🔵🌃 (same handle)! Come join us away from Elon 🦋


Note to self: do not let TSA precheck expire. 🙄


In the clinic, lecanemab causes the same amount of ARIA as in trials (~13%).

In clinical use, lecanemab causes the same amount of ARIA as in trials. #alzheimersdisease @Columbia, @wustl, @UTokyo_News ow.ly/esx850U6W1F



Shannon Macauley Reposted

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease nature.com/articles/s4159…


Shannon Macauley Reposted

Great points by Bill Jagust. "AD is [...] a disease characterized by specific neuropathology [...]. A cognitively normal person with extensive plaque and tangle pathology would receive a pathologic diagnosis of AD" Let's not equate AD and dementia from AD! neurology.org/doi/10.1212/WN…


Shannon Macauley Reposted

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes: @CellCellPress cell.com/cell/fulltext/…

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Shannon Macauley Reposted

Make sure to join us for AAIC advancement: APOE & Lipid Biology. There's going to be some great new insights into everything APOE! Abstract submission deadline is Dec 2. alz.org/apoe/overview.…

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Very excited! My first APOE meeting! Who's in?? @JM_Castell @ErikMusiek @karchlab

It's time to register for #APOE24 !!! (the most interesting genotype, by the way) See you all in Miami!!! 👩‍🔬🌴🏖️🇨🇺 @ApoEdscvr @CourtneyKloske @IgorCamargoF @claire_e_sexton @Morganti_Lab @macauleylab

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Shannon Macauley Reposted

I'm excited to announce that Jennifer Lawrence's thesis work is now out! Check it out here: JCI Insight - Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown insight.jci.org/articles/view/…


Shannon Macauley Reposted

Uploaded another figure to Zotero in case it is of use to anyone: Bibel, B., & The bumbling biochemist. (2024). The TCA (TriCarboxylic Acid) Cycle/Citric Acid Cycle/Krebs cycle acts as a central metabolic hub. Zenodo. doi.org/10.5281/zenodo…

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O. M. G. My baby!!!! I’m so stoked to do this work.

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Shannon Macauley Reposted

New titration protocol for donanemab nearly halves ARIA-E risk. #alzheimersdisease @UCSF ow.ly/x7ak50U3BVo


Shannon Macauley Reposted

We are happy to share our comprehensive review on how sleep influences physiologic systems in atherosclerosis! Check it out in @NatureCVR! 👇 nature.com/articles/s4416…


Shannon Macauley Reposted

Dementia prevention in Africa, a region with many modifiable risk factors, is critically needed. Our multinational Africa-FINGERS, led by the dynamo @MomohChi & colls, offers innovative multidomain interventions tailored to the region's unique challenges➡doi.org/10.1002/alz.14…

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Shannon Macauley Reposted

📅 April 24-25 2025 Join me, @CurePSP , the @RCFNeuro , and the @alzassociation in London for our #Tau2025 Tau Global Conference!💡 Abstract Submission is open! ➡ lnkd.in/gPkqkgj2 Excited to partner with #EuroTau on this exciting event and program!

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