m.sk
@MSakuma8PosDoc in University of British Columbia/Evolution/Enzyme/Single molecule measurement/Microfluidics/Microscope/Running on faith
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@PaolaLaurino
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Our latest manuscript "Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning" is out @NatureComms It is a great collaboration with Francesco Zamponi and Martin Weigt! nature.com/articles/s4146…
Finally published! Thank you so much @PaolaLaurino and all lab members for your continuous support! @OISTeduでの博士研究がオンラインになりました！ #CAZyme #GH19 nature.com/articles/s4146…
Congrats to @d_zome, who published today in @NatureComms part of his PhD work @OISTedu 🥳!!! Pls check it here rdcu.be/dELQk and in the following:
Excited to share our new preprint! We have done a comprehensive bioinformatic analysis of β-lactamases (all major five classes together). The work pretty much repaints our understanding of how β-lactamases are distributed in the environments. biorxiv.org/content/10.110…
Are you interested how #epistasis shapes the AMR evolution? We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. @NatureCatalysis nature.com/articles/s4192…
Happy to share that our latest paper led by @chrfrohlich and @AdrianBunzel is out @NatureCatalysis If you like protein evolution and epistasis, this paper will give you interesting insights; Shifting the rate-limiting step can cause strong epistasis. nature.com/articles/s4192…
Happy to share our new manuscript "Measuring differential fitness costs and interactions between genetic cassettes using fluorescent spectrophotometry". We developed a nice and easy way to determine fitness differences using a fluorescent plate reader. journals.asm.org/doi/10.1128/ae…
Our latest paper "Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution" is now out in @NatureComms A great work from @_karolbuda and @CharlotteMiton, exploring epistasis and idiosyncrasy in enzyme adaptive landscapes. nature.com/articles/s4146…
Origin Of Evolutionary Bifurcation In An Enzyme biorxiv.org/cgi/content/sh… #biorxiv_evobio
We found my father! He seemed to fall down yesterday and hospitalized. He is well now. Thank the person who helped him, VPD and you all!
🚨 Preprint alert! Revealing the mechanisms of EPISTASIS in enzyme evolution (β-lactamase OXA-48). Mutations may be structurally orthogonal, but their combination exhibits powerful epistasis driving AMR. The key? Shifting the rate-limiting step! biorxiv.org/content/10.110…
公募班・加藤グループとD01班・本田教授グループとの共同研究の成果です。安価なキチン粉末を用いた Strep-tag 融合タンパク質の精製手法を開発しました。 onlinelibrary.wiley.com/doi/10.1002/an…
So excited to get to share the preprint of our work (also my very first research article!) at the @tokuriki_lab demonstrating that evolution under static selection pressures can promote functional diversity, and thus population-level evolvability, in proteins.
Thrilled to share our latest preprint collab with the amazing Tokuriki Lab (@tokuriki_lab) and the lead author, Ayse (@erdogananisan)! We explain how the combination of neutral drift & threshold selection maintains phenotypic variation. biorxiv.org/content/10.110…
Happy to share our recent preprint "Neutral Drift and Threshold Selection Promote Phenotypic Variation". This work touches on a profound question of how "phenotypic variation" can arise from evolutionary drift in a simple and static environment. biorxiv.org/content/10.110…
Chem-Stationにて酵素1分子計測(JACS, 2023)の研究成果を掲載していただきました！
【注目プレスリリース】回転分子モーターの動きをコントロールする「留め金」はモーターの回転方向に依存して外れる ――ATP合成酵素の制御機構の解明―― / 分子科学研究所 research-er.jp/articles/view/…
Our paper is now out from @NatureComms, entitled "Molecular mechanism on forcible ejection of ATPase inhibitory factor 1 from mitochondrial ATP synthase" doi.org/10.1038/s41467…
Happy to share our new preprint conducted by @_karolbuda and @CharlotteMiton, "Higher-Order Epistasis Creates Idiosyncrasy, Confounding Predictions in Protein Evolution". biorxiv.org/content/10.110…
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Who to follow
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Paola Laurino
@PaolaLaurino -
Taro Furubayashi (古林 太郎)
@fbayashi_T -
Shingo Honda (本田 信吾)
@akg_entrance -
Ryohei Kobayashi
@ry_kbys -
市橋 伯一 Norikazu Ichihashi
@Nori_Ichihashi -
Charlotte Miton
@CharlotteMiton -
Naohiro Terasaka 寺坂 尚紘
@NaohiroTerasaka -
Ichihashi Lab Komaba
@KomabaLab -
ShunsukeTAGAMI
@ShunsukeTAGAMI -
Ayşe Nisan Erdoğan
@erdogananisan -
matsubayashi
@Matsubayashi_J -
Scallion
@RemakeSystems -
yutetsu kuruma
@liposomania -
Kaiyu Qiu 邱锴宇
@21qiu -
Dan Kozome
@d_zome
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