Meng-Ju Wu
@MJWu_TWAssistant Professor @UMassChan interested in tumor metabolism/immune microenvironment. Views are my own
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New in @sciencemagazine! Our study reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Read more: science.org/doi/10.1126/sc… #CancerResearch #Cholangiocarcinoma #IDH1 1/n
Another cool study!Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells: @CellCellPress cell.com/cell/fulltext/…
Ten years ago, I wrote a research proposal with a big question in mind: what role do the lncRNAs play? Now, a decade later, and with the incredible members in the @nevillesanjana lab, I'm finally starting to uncover some answers. Check our findings now published in @CellCellPress
Can’t wait to share this beautiful story from my friend @yujungche published on @Nature Are you also interested in cancer metabolism? Take a look! nature.com/articles/s4158…
I’m excited to share our latest study in @nature on this novel compound called Gliocidin, that targets glioblastoma (#GBM), the most malignant brain tumor. #drugdiscovery #cancer #cancermetabolism @GSKGradSchool @MSKCancerCenter nature.com/articles/s4158…
tidyplots Time to say goodbye to ggplot2?🫡 "a significant reduction of code complexity" vs ggplot2 cran.r-project.org/web/packages/t… @JanBroderEngler bioRxiv 2024 biorxiv.org/content/10.110…
Congratulations @davetingmgh @EunaeYou476 on their latest work in @CellCellPress, showing how repeat RNA elements in extracellular vesicles create a viral-like infection in the pancreatic cancer microenvironment. cell.com/cell/fulltext/…
What a wake-up call! UMass Chan congratulates Victor R. Ambros, PhD, the Silverman Chair in Natural Sciences and professor of molecular medicine at @UMassChan, co-winner of the 2024 @NobelPrize in Physiology or Medicine for the discovery of microRNA: direc.to/mmHu
Congratulations to our 2024 medicine laureate Victor Ambros ✨ This morning he celebrated the news of his prize with his colleague and wife Rosalind Lee, who was also the first author on the 1993 'Cell' paper cited by the Nobel Committee. #NobelPrize
UMass Chan Medical School researcher Victor R. Ambros, PhD, arrives on the @UMassChan campus with his wife, Rosalind "Candy" Lee, after learning he is sharing the 2024 @NobelPrize in Physiology or Medicine. WATCH news conference at 10 a.m. EST: direc.to/mmGC #NobelPrize
Looking for an up to date review on dna sensors and their role in autoinflammatory diseases check out this review from @Mingqi7up 👇
nature.com/articles/s4159… I hope this is a helpful review! Appreciate the opportunity to co-write this review in @NatImmunol with my mentor @FitzgeraldKate Thanks to all the reviewers' comments which significantly elevated our work and thanks to the unsung artists for their art!
Today is my last day @MGHCancerCenter . I want to thank my mentor Dr. Nabeel Bardeesy’s guidance and support past years and to thank other great mentors and colleagues at MGH, Harvard and Broad. I had a great journey here. I’ll start my new adventures @UMassChan next Tuesday!
Excited to to share Dr. Gritti’s (my wonderful colleague) work on DNAJB1-PRKACA in Fibrolamellar Carcinoma, a rare but aggressive liver cancer in young people. Limited models make studying FLC tough, but this research is a huge step forward! @CD_AACR doi.org/10.1158/2159-8…
Excited to share our new work on how DNAJB1-PRKACA drives cancer cell growth in Fibrolamellar Carcinoma. @CD_AACR Thanks to all our collaborators and funding support. @FibroFoundation @AICF_nyc @DonaBertarelli @ForbeckForums @AlexLemonade
It seems that many people do not see our previous Light paper and many fun movies associated with it. Here I just show the interesting mitochondria ones😀from this paper here nature.com/articles/s4137…
Super cool story on how PROX1 loss drives hepatocyte fate loss, leading to HCC-to-CCA identity changes! Glad I got to hear this fascinating presentation in person at the CSHL meeting a few weeks ago!
Excited to share our first preprint with @zauggj @embl! We screened 1,296 transcription factors for repressors that block unwanted plasticity and found many putative tumour suppressors. PROX1 stands out as hepatocyte safeguard that prevents #livercancer. biorxiv.org/content/10.110…
Congratulations to Zhijian “James” Chen, 2024 #LaskerAward winner! – “for the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses.” laskerfoundation.org/winners/cgas-e… #Lasker2024 #LaskerLaureate
Hi #metabolism twitter. ~5 years ago wrote a review with @mvh_lab and @DMM_Journal about how the microenvironment drives many metabolic features/targets of cancers: tinyurl.com/3sk263z9 1/7
In a study funded by our division, @MJWu_TW et al. revealed a new mechanism for viral mimicry in triggering an immune response underlying the antitumor activity of mutant isocitrate dehydrogenase 1 (IDH1) inhibitors @ScienceMagazine science.org/doi/10.1126/sc….
🧬🚨 Our study on novel antigens induced in glioblastoma upon treatment with epigenetic therapy is out!! This study was led by @joshhjang with co-first-authors @leung_holden and @JuheonM, and mentored by @twang5 and @AlbertHKimMDPhD 5 Key Takeaways: 1/5 nature.com/articles/s4158…
Our latest paper "NaCl enhances CD8+ T cell effector functions in cancer immunotherapy" is now out @NatImmunol nature.com/articles/s4159… 🥳🎉🍾. A 🧵:
The FDA approved Servier’s IDH1 and IDH2 inhibitor vorasidenib for IDH-mutant glioma following surgery, providing the first new drug in decades for this rare cancer nature.com/articles/d4157…
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