James A. Letts
@LettsScienceAssistant Professor of Molecular and Cellular Biology, UC Davis. Membrane protein biochemistry, biophysics and structural biology #cryoEM. Bioenergetics.
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My lab is recruiting a postdoc to work on biochemistry, structure and function of plant🌱respiratory complexes and supercomplexes! Come join us at UC Davis! Learn more about the lab here: letts.faculty.ucdavis.edu Apply for the job here: recruit.ucdavis.edu/JPF06484
Symbiont-housing structures are rarely studied in unicellular protists. Jerlström-Hultqvist et al. show that low-oxygen-adapted Anaeramoebae have symbiosomes positioning sulfate-reducing bacteria near hydrogenosomes. @jon_hultqvist @andrewjroger nature.com/articles/s4146…
Now out in PNAS - we show how lansoprazole - a common acid reflux drug, blocks the respiratory enzyme of M. smegmatis, a close relative of tuberculosis bacteria. Wonderful collaboration w Högbom & Brzezinski labs. Thank you @KAWstiftelsen for funding. pnas.org/doi/full/10.10…
Working with a great team to organize @KeystoneSymp #Microproteins: from Discovery to Applications! Abstract deadline is Nov 6th. Please submit your exciting work and join us in Beverly, MA, USA in Feb2025! keysym.us/KSMicroprotein… #KSMicroproteins25 https://t.co/of7cMgIwVP
The structures of protein kinase A in complex with CFTR: Mechanisms of phosphorylation and noncatalytic activation | PNAS pnas.org/doi/10.1073/pn…
I can never ever put in words how this community has shaped my faculty & personal journey 🙏🏼 This is that safe space of trust & unconditional support of each other without cut-throat competitive environment we often see in academia. Please apply and join this great community! ❤️
📢 Applications for the 2025 Leading Edge cohort are now open! Deadline: Feb 3, 2025 leadingedgesymposium.org/apply/ In its first 5 years, Leading Edge has supported 200 incredible scientists. We are excited to grow our community with a sixth cohort!
🍂NEW VIDEO🍂 All through Autumn, trees race against time to recycle their chlorophyll--and basically everything else in their leaves. But why go through all this effort? The answers are honestly mind-blowing: rendered in #blender3d using @bradyajohnston's #molecularnodes
Now out in JSB! High res imaging of memb proteins in *native* vesicles opens new frontiers We've done it with V-ATPase in synaptic vesicles & mycobacterial ETC complexes in inverted PM vesicles. Vesicle Picker is our 1st new tool for this type of analysis: sciencedirect.com/science/articl…
1/x: Happy to share our new #cryoem @biorxivpreprint: “Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene”, lead by outstanding student Dr. Kookjoo Kim! Read on: 🧵 biorxiv.org/content/10.110…
.@AmeeeenNeuro @guiwitz @ben808080 et al. @unibern developed CryoVesNet, which enables accurate segmentation of synaptic vesicles in cryo-electron tomograms. This tool advances our understanding of synaptic function and synaptic vesicle pool dynamics. hubs.la/Q02VJ0KH0
Our elemental mapping work, combining cryo-EM and EELS to REEL analysis, is now also published on Nature Methods: nature.com/articles/s4159… For a highlight “reel”, see here 👇
Happy to announce that our efforts to establish elemental mapping for cryo-EM ❄️ by EELS 🌈 are now shared on bioRxiv: biorxiv.org/content/10.110… Congratulations to @zoliviapg and co-authors! But wait - Can we map elements in 3D? 🧵👇 1/6
Extremely proud to share our integrative work on how 'Dissected antiporter modules establish the minimal proton-conducting elements in Complex I' – now out in Nature Comms! Many thanks to @KAWstiftelsen & @Vetenskapsradetfor funding. nature.com/articles/s4146…
New #CryoSPARC case study! End to end #cryoEM processing of encapsulin and encapsulated ferritin, with a focus on challenges and strategies for handling mixed high-order and non-point-group symmetries. guide.cryosparc.com/processing-dat…
Water bears (also known as tardigrades) are famous for their ability to survive in just about any condition thanks to special protective proteins. Researchers in the @cijilim & @GrantCryoEMLab labs turned to these proteins to solve a challenge in #cryoEM: biochem.wisc.edu/2024/10/16/an-…
Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and respiration in mycobacteria | bioRxiv biorxiv.org/content/10.110…
🚨 We're hiring! 🚨 Join our team as a PhD student or postdoc in our ERC-funded project focused on re-building small GTPase networks. If you're excited about protein biochemistry, fluorescence microscopy, and cryo-EM, we'd love to hear from you! Apply now: ista.ac.at/en/job/postdoc…
A massive team effort, “Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and respiration in mycobacteria.” Cryo-EM methods AND fundamental insight into mycobacterial metabolism, which is a target for TB drugs! 🧵 biorxiv.org/content/10.110…
We recently spent a day in the lab with 2024 @NobelPrize winner and HHMI Investigator David Baker, where he discussed his groundbreaking work, the importance of basic science, and his passion for mentorship #NobelPrize
I’m excited to share our latest preprint, where we showcase the development of two computational tools to facilitate the analysis of highly heterogeneous cryo-EM datasets. (1/7) biorxiv.org/content/10.110…
Just reminded of another gorgeous video of mitochondria, this time at higher resolution allowing to see the internal membranes (cristae) where oxygen is consumed to charge the mitochondrial inner membrane and make ATP x.com/AndyBiotech/st…
Wow, this is simply fascinating! pnas.org/content/116/32… Live mitochondria seen in unprecedented detail with ∼60 nm superresolution phys.org/news/2019-08-m…
New Title Alert: relionsparc- a Python Utilities program for converting between Cryosparc and Relion File Formats. More here: buff.ly/3TfG79G #SBGrid #structuralbiology #SBGridsoftware
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