Katherine Albanese
@KIAlbanesepostdoc in @WoolfsonLab, PhD in @waterslab_UNC. chemistry, baseball, and counting crows.
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Looking for PhD students to join the new Cross lab, using protein engineering and design to manipulate intracellular transport! swbio.ac.uk/biomolecular-a… Project 62 Get in touch if you're interested in joining us! Working with @WoolfsonLab @MarkDodding @BristolBiochem @BristolChem
Proud to share this work led by @ChubbJoel, who will excitingly be joining us as a postdoc in the new year! We can't wait for you to be here!!! 🥳🥳
Excited to share our latest designed A3B3 α-helical barrels, revealing how subtle the heptad register shift impact helix orientation. Well done to @ChubbJoel @KIAlbanese and team @WakeChemistry @Macquarie_Uni Read more here biorxiv.org/content/10.110…
The Albanese Lab is officially operational! Undergraduates Sam, Miko, Susy, and Wonhee preparing to express their first proteins 🧑🔬👩🔬
Excited to share our latest designed A3B3 α-helical barrels, revealing how subtle the heptad register shift impact helix orientation. Well done to @ChubbJoel @KIAlbanese and team @WakeChemistry @Macquarie_Uni Read more here biorxiv.org/content/10.110…
Check out this amazing woman's research!
My first postdoc paper is now in @J_A_C_S! By incorporating SuFEx chemistry and protein engineering we covalently stabilized an 18-subunit protein-peptide complex, enhancing stability and homogeneity for high-precision applications like DNA sequencing. 1/9 pubs.acs.org/doi/10.1021/ja…
Excited to see our work in print at Nature Chemical Biology today! We are using protein/peptide design to manipulate the activity of kinesin-1 motors in cells. @MarkDodding @WoolfsonLab @BristolBiochem nature.com/articles/s4158…
Trimethyllysine Reader Proteins Exhibit Widespread Charge-Agnostic Binding via Different Mechanisms to Cationic and Neutral Ligands | J. American Chemical Society @UNC @UNCResearch @waterslab_UNC #Trimethyllysine #Reader #Proteins #Agnostic #Binding pubs.acs.org/doi/10.1021/ja…
Excited to pre-print our new work, applying protein to design to engineer an allosteric switch into kinesin-1 motors in vitro and in cells. biorxiv.org/content/10.110… @MarkDodding @WoolfsonLab @BristolBiochem
Thank YOU @treacy_billy for all of your incredible efforts as well!
Check out this fabulous work from the @waterslab_UNC (Both past and present)! Through use of high throughput screening, genetic code expansion, and energy decomposition analysis, we were able to challenge paradigms surrounding Kme3 reader protein binding. chemrxiv.org/engage/chemrxi…
Friday submission day - Katherine and Rokas enjoying their celebratory cold beers at Bristol’s iconic suspension bridge, kudos to them both for their hard work!! Check it out biorxiv.org/content/10.110…
Please retweet!📢📢 We are looking to appoint a BBSRC-funded post-doctoral research associate to work in the area of de novo enzyme design with alpha-helical barrels using computational design, protein biochemistry, and directed evolution. More details below
Merry Christmas from the Woolfson lab!!! 🛼🥳❄️
The Woolfson thanksgiving dinner 2.0
Are you looking for robust antiparallel 4-helix coiled-coil modules for chemical and synthetic biology applications? We designed a common set of rules for antiparallel homotetramer, heterotetramer and single-chain protein. Find more in @ChemicalScience pubs.rsc.org/en/content/art…
Super excited that our work on the rational design of 310-helical bundles is now out in @Nature! Congrats Prasun @dgr8ashoka for this impressive piece you have led in collaboration with @ClaydenGroup and @DiamondLightSou! You can read it here: nature.com/articles/s4158…
fun collaboration with a lot of great people to bring together experimental, computation, and PDB analysis to dive deep in these fundamental and relevant interactions.
Check out the latest from the Waters Lab: we analyze sulfonium-π, ammonium-π, and sulfur-π interactions in a β-hairpin peptide model system, alongside computational and PDB analysis! Congrats to Katherine and our collaborators! @KIAlbanese pubs.acs.org/doi/full/10.10…
Check out our latest paper: a mechanistic study of the CBX5 chromodomain binding to dialkyllysine-containing chemical probes! Congrats to Kelsey and our collaborators in the James Lab (UNC) and the Houk Lab (UCLA)!! pubs.acs.org/doi/full/10.10…
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