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Preprint is out! We were genuinely surprised to discover that the same antibody showed different binding modes with the WT and Omicron variants—a finding we never anticipated, which correlated with neutralization loss, then diligently explored the underlying mechanisms.
Distinct Binding Modes of Inter-Spike Cross-Linking Suggest a Supplementary Mechanism for SARS-CoV-2 Antibody Neutralization biorxiv.org/cgi/content/sh… #biorxiv_immuno
Remember, I said 5ml bacterial cultures for the isolation of ribosomes. Well, I was wrong you need 1ml culture at 0.3 -0.5 absorbance at OD600nm for this "Ribosome and RNA mini prep". Pretty good for CryoEM or any biochemical tests. Here in these figures are ribosomes purified in…
Happy to share the latest preprint from our lab led by our very talented postdoc Fernanda Sala! We determined structures of the Nipah Virus RNA polymerase complex in its apo state and with template and product RNA bound during early replication! biorxiv.org/content/10.110…
“RNA-binding to RdRP core leads to the ordering of flexible C-terminal domains”🤩 the full-length structure of L-P complex for Nipah is out
Structure of the virulence-associated Neisseria meningitidis filamentous bacteriophage MDAphi Congrats @janboeh @AbulTarafder @miles_a_graham @MathieuCoureuil @MRC_LMB @NeckerInem biorxiv.org/cgi/content/sh…
I’m very happy to share our work on evolving capping T7. Directed evolution of an orthogonal transcription engine for programmable gene expression in eukaryotes biorxiv.org/content/10.110…
Structural basis for adhesin secretion by the outer-membrane usher in type 1 pili | PNAS pnas.org/doi/10.1073/pn…
Scott C. Blanchard to Receive the 2025 Kazuhiko Kinosita Award in Single-Molecule Biophysics biophysics.org/news-room/scot…
Thank you to each of you who came to be our guest at the Award for Innovation in Healthcare and Bioscience. Handshakes, hugs, a shared meal, laughter and learning from an expert in his field, @McLellan_Lab It was a beautiful evening.
After pandemic delays/starting residency, I am THRILLED to finally get this paper out 🤗 a combo of my favorite things: pretty protein/antibody structures and a live Nipah experiment 🥰 (and working with @sope_oguntuyo) enjoy our latest w/ mAb92 🦠 #nipah journals.asm.org/doi/10.1128/jv…
#MERS vaccines built on our two-component protein nanoparticle platform induce robust neutralizing antibody responses and protect mice against vaccine-matched challenge. This collaborative project was led by @chao_cara and is out now on @biorxivpreprint: biorxiv.org/content/10.110…
Over the last 4 years our immune system kept evolving to fight SARS-CoV-2. In our last work, published on @CellReports, we longitudinally analyzed different cohorts to understand the evolution of the antibody response to SARS-CoV-2. Here the full paper: cell.com/cell-reports/f…
Antigenic sin and multiple breakthrough infections drive converging evolution of COVID-19 neutralizing responses dlvr.it/TCTcqz
These substitutions also provide enhanced thermostability and cellular expression, allowing complete structural characterization of the closed prefusion conformation via cryo-EM (kudos to Ling Zhou, @AcremanCory, and @McLellan_Lab) (PDB ID: 8VAO rcsb.org/structure/8VAO)
We are excited to share the review we have written to explain the concept of signaling bias to a broad audience.
Have questions about preparing your data and submitting your structure to the PDB? Register for the Sept 12 Virtual Office Hour: Streamlining PDB Deposition rcsb.org/news/feature/6…
Everything you ever wanted know about antibody feedback and immunological imprinting* …*but were afraid to ask. @_voss_w_ @JasonJ_Lavinder cell.com/cell-reports-m…
Now this paper is published in its final form. Thanks to Daniel and Ece for their hard work, and to our collaborators Bill Wimley @WilliamWimley and Elena Pasquale.
Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer nature.com/articles/s4146…
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Agalliu Lab
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shee-mei lok
@LokShee -
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