Chii Jou (Joe) Chan
@ChiiJChan1Biophysicist in early mammalian development. PI/Asst Prof @MBIsg. Postdoc @EMBL from Hiiragi lab and @Prevedel_Lab, PhD @Cambridge_Uni @GuckLab
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Sharing 2 new papers from the lab where we investigate ovarian mechanics during ageing using biophotonics, and propose its use in understanding tissue hydraulics during folliculogenesis - congrats to the teams! doi.org/10.1007/s12551… doi.org/10.1101/2024.1…
It’s been an honor to present our story on stiffness and folliculogenesis to the @MBIsg @NUSMedicine Thank you @ChiiJChan1 for the invitation! Looking forward to more interactions with the mechanobiology community
Front cover alert 🚨 our research on the mechanics behind a dog's iconic wet nose is featured on the @CurrentBiology cover! Learn how skin growth & blood vessels shape those unique grooves & domes - a must read for biology & physics fans 🐶🔬 @UNIGEnews cell.com/current-biolog…
New paper alert! Amazing grad students @levy_ezra and Isabella Leite live image female germline cyst formation in embryonic gonads of mice and discover that even as these structures form, through divisions with incomplete cytokinesis, germ cells are incredibly motile.
Very happy to share the first article from my postdoc work in the Tomancak lab! biorxiv.org/content/10.110…. We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)
Life at low and high Reynolds numbers! A great, wide ranging talk from David R Nelson @harvardphysics on how fluid flows can affect growth of microbial populations, from oceanic simulations 🌊 to lab microorganisms 🦠
Excited to share our latest work on an image analysis paradigm that combines cell state and morphology analyses of patient biopsies at single cell resolution to uncover clinically relevant head-and-neck #cancer phenotypes! @CellCellPress cell.com/cell/fulltext/… tweetorial👇
Our latest issue just dropped. And it's special! A high-density assortment of essays primer and reviews on #physics in #biology! Check it out! cell.com/current-biolog…
Welcome to The Many Faces of Active Mechanics (#activesolids-c24) conference at #KITP! Learn more at: kitp.ucsb.edu/activities/act… Stay tuned for recorded talks at: online.kitp.ucsb.edu/online/actives…
Glucose has a surprise role in directing cell fate and migration go.nature.com/4hcwMtM
What happens at the very first moment when sperm & egg meet? We discovered a conserved trimeric ‘key’ on vertebrate sperm that binds to divergent egg proteins. Amazing work jointly lead by @deneke_v & Andreas Blaha @PauliGroup cell.com/cell/fulltext/…
The life of each one of us began when a sperm and an egg came together. But what actually happens at a molecular level? Our latest work @PauliGroup @CellPress reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/8) cell.com/cell/fulltext/…
Our latest out today @Nature! We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬 nature.com/articles/s4158…
Huge congrats to you and the team! Good stuff deserves the wait..this work has huge implications :)
Seems like ages ago! Our story is now published in Science. Don't read the quoted post, check-out the published paper instead: science.org/doi/10.1126/sc… 🥳 🥳 🥳
We're delighted that both have connections to Cambridge: Geoffrey Hinton is a Cambridge graduate and Geoffrey Hopfield was a researcher at the Cavendish Laboratory as a Guggenheim Fellow. Image: @NobelPrize
Our study decoding gastruloid symmetry breaking is now live @NatureCellBio! rdcu.be/dVMLG Thank you to the NCB edititorial team and to our reviewers for a constructive review process which helped improve our study. A thread on updates (1/n):
S’pore researchers discover ‘spa’ treatment can turn back clock on older women’s eggs straitstimes.com/singapore/s-po…
Our great @RubenBoot_DWIN and colleagues have found that spheroid viscoelastic behaviour is pressure- and deformation-dependent during mechanical aspiration. Check it out😍👇 nature.com/articles/s4159…
Beautiful work! I have been teaching courses on tissue self-organisation and this is another emerging evidence of mechanical signalling at the core of this paradigm shift
We are pleased to share our latest preprint on the link between intracellular density and mechanical pressure! Using quantitative phase microscopy, we show that density increases proportionally to pressure. More information here👉 tinyurl.com/e7a75y63 Congrats to @Hyojun_Kim_
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