Song Cao
@scsongcaoComputational biologist | Washington University School of Medicine | Bioinformatics | Cancer genomics, cancer proteomics, and cancer virology
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This week, we’ll be posting about the articles featured in the @NaturePortfolio Collection on "#HTAN: exploring tumor evolution in time and space." nature.com/collections/fi…
Comprehensive genome analysis and variant detection at scale using DRAGEN nature.com/articles/s4158… #journals #feedly
Additional info can be found in an @theNCI Cancer Currents Blog about Dr. Padmanaban’s recent @Nature study showing that #BreastCancers have an unusual way of exploiting sensory nerves to help them spread to other parts of the body. cancer.gov/news-events/ca… #NCIsysbio24
Online Now: Integrating priorities at the intersection of cancer and neuroscience dlvr.it/TFZFqh
Spark in the darkness: Discovering action potentials in brain tumors dlvr.it/TFTcLD
Very grateful to @Cancer_Cell for thoroughly spotlighting our work on hematopoietic aging, IL-1 and DNMT3A, and their vital roles in aging-driven tumor progression! Read the spotlight: doi.org/10.1016/j.ccel… View our paper: science.org/doi/10.1126/sc…
Architecture sets the path: Breast cancer subtypes differently shape the early brain metastatic niche dlvr.it/TFS68C
Using data from a cohort of 402 #LungAdenocarcinoma patients and from multiple independent cohorts, DNA #Methylation signatures were evaluated to build and validate an accurate model predicting #BrainMetastasis development. @JeffreyZuccato @gelarehzadeh nature.com/articles/s4159…
Our new (eDynamic/Cancer Grand Challenges funded) publication on ecDNA is now online, showing that ecDNAs play a role in treatment response and cancer progression. Thanks to all involved and especially @wisekh6 and team for the excellent collaboration.
Congrats #CancerGrandChallenges team eDyNAmiC on its paper in @NatureGenet ⭐️ By studying > 8000 cancer genomes, the team highlighted ecDNA's role in providing a competitive advantage during cancer progression, treatment response & metastasis. Read 👇 doi.org/10.1038/s41588…
Long-read sequencing of an advanced cancer cohort resolves rearrangements, unravels haplotypes, and reveals methylation landscapes. @sjmjones et al. cell.com/cell-genomics/… "189 patient tumors and 41 matched normal samples sequenced using the @nanopore PromethION platform"
A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy @NatureBiotech @michal_bassani nature.com/articles/s4158… nature.com/articles/s4158…
Prediction of brain metastasis development with DNA methylation signatures nature.com/articles/s4159…
New @Nature paper from @FSkoulidis et al @MDAndersonNews (with a large slate of investigators in this team effort): CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors nature.com/articles/s4158…
The 2024 #NobelPrize laureates in chemistry Demis Hassabis and John Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins. In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have…
Widespread transposable element dysregulation in human aging brains with Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…
1/ The term "chronic EBV" used to elicit an🙄from many (most?) clinicians before this enormous study profiling over a million service people for decades found a causative association between Epstein Bar Virus (EBV) and Multiple Sclerosis (MS). science.org/doi/10.1126/sc…
Online now: The transcription regulators ZNF750 and LSD1/KDM1A dampen inflammation on the skin’s surface by silencing pattern recognition receptors dlvr.it/TDrdHT
Primary structure of histone variants and their influence on nucleosome structure #Figure from the #Review by Lee H. Wong @MonashUni & David J. Tremethick @JCSMR: Multifunctional histone variants in genome function go.nature.com/4dDLXcI Free to read: rdcu.be/dQO4i
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