Isidro Cortes-Ciriano
@isidrolauscherResearch Group Leader at EMBL-EBI @emblebi & Associate Faculty at @sangerinstitute. @CR_UK Career Establishment Awardee. Cancer genomics.
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To close 2023, we present our work on #osteosarcoma genome and clonal evolution biorxiv.org/content/10.110… How does #osteosarcoma arise? What rearrangement mechanisms cause some of the most complex #chromothripsis events seen in human cancer? Does chromothripsis occur subclonally?👇
📢Awesome talk alert! A reminder that @McclellandLab will be giving a Chromosomal Instability lecture tomorrow👇Zoom link: cam-ac-uk.zoom.us/j/84115680528?… Meeting ID: 841 1568 0528 Passcode: 491672 Don't miss it- Sarah's lab work is terrific! @markowetzlab @DKFZ @emblebi @CRUKCamCentre
#CARTcells for #DIPG #DMG clinical trial (1st arm) results are out today. Full Tweetorial coming, but first want to share the story of a patient whose #DIPG has disappeared for over 3 years. It is a milestone and moment of hope on a journey filled with so much grief. “There’s a…
We have a deluxe keynote speaker! @isidrolauscher explains how complex chromosomal rearrangements are very common in many cancers ✅ And shows how we can use nanopore sequencing to implement liquid biopsy in the clinic for pediatric tumours 💪
Venir a #Zaragoza es siempre una suerte. Hacerlo para hablar de ciencia, un privilegio! Muchas ganas de presentar la ciencia de nuestro grupo mañana en el @ASEICAnews Joven retreat en @FundIbercaja !
‼️Mañana es el día! La Semana de la Ciencia de ASEICA empezará con el Retreat #ASEICAJoven–@FundIbercaja ¡No te lo pierdas! 📅12-N (Zaragoza) 1⃣6⃣charlas seleccionadas 📢KEYNOTE Speaker @isidrolauscher @emblebi @CR_UK 🎯Ciencia y Networking 👉aseica.es/aseica-joven-i…
Join us in Stresa, Italy for the amazing @embo Chromosome Segregation and Aneuploidy organized by @SteSantaguida @ELogarinho @BenDavidLab @Foijer_lab @McclellandLab and myself. Registrations are open now! meetings.embo.org/event/25-aneup…
We are very excited to open the registration for the upcoming @EMBOevents on Chromosome Segregation and Aneuploidy in beautiful Stresa!!! You can find all the relevant info at meetings.embo.org/event/25-aneup… Hope to see many of you in a few months!! 🧬🔬😍 #ChromoPloidy25
Thank you @NatureRevCancer for highlighting our recent work on chromothripsis! Here’s a link to the paper: cell.com/cell/fulltext/…
II'm excited to finally share our study on the mutational landscape and selection dynamics in sperm, now live on medRxiv: medrxiv.org/content/10.110…. We explored how positive selection impacts mutation rates, especially with age. Here’s a quick thread on our findings! 🧵👇
I'm still involved in a bit of mouse genomics ;) 🐭🐭🐭 The structural diversity of telomeres and centromeres across mouse subspecies revealed by complete assemblies biorxiv.org/content/10.110…
Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/n medrxiv.org/content/10.110…
🚨🚨 PAPER ALERT - Here’s our latest paper - where we looked at the local outcomes of nearly 5000 patients recruited in the NHS Central and South Genomics GMSA in the 100,000 Genomes project (1/n) nature.com/articles/s4141…
The "Insect Apocalypse (@nytimes)" is happening, with insects declining by 75% in the past 50 years (@guardian). In @ScienceMagazine, "Pervasive sublethal effects of agrochemicals on insects at environmentally relevant concentrations," we look at causes science.org/doi/10.1126/sc…
Delighted to share our work in @NatureGenet using base editing to map genetic mechanisms of drug resistance. If you're interested in drug discovery then check it out. Access here rdcu.be/dXmlo [rdcu.be]. Congratulations to the team and @MatthewACoelho
Today we report in @NatureGenet the genetic landscape of cancer drug resistance mechanisms from CRISPR base editing screens nature.com/articles/s4158…
Are you a student in France studying computer science, statistics, or bioinformatics? @FranceintheUK has opened a new round of internships hosted at EMBL-EBI. Find out more and apply. ebi.ac.uk/about/jobs/int…
Vous étudiez dans une université française ou une Grande École ? Vous souhaitez en savoir plus sur la bioinformatique ? Vous voulez travailler en Europe et vivre à Cambridge au Royaume-Uni ? Ce stage est fait pour vous...
Are you a student in France studying computer science, statistics, or bioinformatics? @FranceintheUK has opened a new round of internships hosted at EMBL-EBI. Find out more and apply. ebi.ac.uk/about/jobs/int…
We’re looking for a motivated PhD student to join our team at VHIO for an exciting computational immuno-oncology project. Want to be part of our young, dynamic team? Check out the position and apply! 💻🧬 #PhD #CompImmunoGenomics vhio.net/vhio-phd-oppor…
Delighted to announce the launch of our MANIFEST IO research platform @MANIFEST_CIRRP 🔬 We are a UK-wide consortium of academic institutions, NHS trusts & industry partners - with a shared vision to understand how patients with cancer can best benefit from immunotherapy. 🧵1/5
I am really happy to see the #preprint of our work studying #acral #melanoma tumours from 🇲🇽 Mexican patients out today! This has been a ~8 year-long work involving many colleagues from Mexico and abroad. Some of our findings here below.... ⬇️ (1/12)
Ancestry and somatic profile predict acral melanoma origin and prognosis medrxiv.org/cgi/content/sh… #medRxiv
We have an open postdoc position in my group! The projects of the lab are focused on understanding how cancer genomes dictate immune responses, tumor evolution, and therapy resistance. Come join us in a great environment! vhio.net/2024/09/18/ref…
I'm really grateful to @isidrolauscher who has taught me so much in the last few years, and without him I would not be here 🙏. This acknowledgement extends to the rest of the group and the many collaborators we have had during my time at @emblebi
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