Sasha Tarakhovsky
@sashatarakhhead of the lab at the Rockefeller University, main interests: epigenetics of virus-host interaction. Views of my own.
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I am quitting Twitter with the following notice. Time to think and reflect not to post m.youtube.com/watch?v=RT8FFv…
I am looking for a postdoctoral fellow who is interested in the toxin-antitoxin paradigm and it’s possible role in antiviral defense in mammalian cells.
Exciting!
Here it is: the allosteric map of a protein. Want to find all the sites to target in your favourite undruggable protein? Here's how you can do it. >22k biophysical measurements for one protein (KRAS) Congratulations to @WengChenchun and @aj4re biorxiv.org/content/10.110…
A cross section of a eukaryotic cell, a 3d rendering by Evan Ingersoll & Gael McGill visualising the complex molecular choreography the pathways and processes enabling life Made using data from X-ray, nuclear magnetic resonance & cryo-electron microscopy gaelmcgill.artstation.com/projects/Pm0JL1
How can a single cell learn without a brain? We explore this in my first paper from my PhD with @WallaceUcsf, co-first-authored with @TMakushok! We discovered that gradual habituation in a cell population is due to step-like switches in single cells bit.ly/3GNg702 🧵1/n
We're heading to a universal toolkit to engineer cells for diverse applications: cancer, autoimmune conditions, neurodegenerative diseases, repair of injured tissue and organs science.org/doi/10.1126/sc… This week's @ScienceMagazine special section
CRISPR-based genome editing has been transformative, but insertion of large sequences requires DNA damage machinery How can we efficiency place DNA cargos anywhere in the genome? Today we report on PASTE, out in @NatureBiotech w/ @omarabudayyeh @MIT nature.com/articles/s4158… 1/🦃
A guide to antigen processing and presentation | Nature Reviews Immunology. This will be heading straight into my teaching lectures next term 👇 nature.com/articles/s4157…
Likewise, awed and inspired by these spectacular leaders and scientists including you @danetteldaniels
So inspired by these amazing women in chromatin and epigenetics research ❤️Professors Anne Schaefer, Karen Adelman @AdelmanLab, Michaela Frye, Yael David @David_Lab_MSK, Andrea Schorn, and Shelley Berger!
A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus @The_InnovationJ article hubs.li/Q01sy_D80
#WeekendReads! #WeAreWhatWeEat + #InterferonPower! Feng & friends show @CellReports that mice fed a grain diet survive #influenza infection, while mice fed an ultra-processed diet all died. #Interferon gamma blockade protected from mortality! cell.com/cell-reports/f…
Musk is not exactly Donald Trump. But both represent the emergence of a particularly American personality in the early decades of the 21st century: the wildly disruptive narcissist.
🤯 amazing!
Our first preprint is out! Led by Rohith Rajasekaran (@born2raisecell): “A programmable reaction-diffusion system for spatiotemporal cell signaling circuit design” A visually stunning toolkit to build cellular radios that probe or control cell biology. biorxiv.org/content/10.110…
Happy to quote Anton Zeilinger who wants to encourage young researchers to do fundamental research: “My advice would be: Do what you find interesting, and don’t care too much about possible applications.” This could be the motto for @ERC_Research Congrats, Anton!
Congratulation to the 2022 #NobelPrize in Physics! The ERC is proud to have funded Alain Aspect and Anton Zeilinger 🏅 #EUfunded
Folk artist goes viral for his uncanny 3D graffiti painting
How do immune cells stop themselves from aging & stay young? Turns out T cells can acquire telomerase from antigen-presenting cells and escape senescence! Fascinating new anti-aging mechanism used by the immune system for long-lasting protection nature.com/articles/s4155…
Received a grant to study nasal anti-CD3 in ALS. We found that nasal anti-CD3 treats models of ALS by dampening microglial activation. Although ALS is a motor neuron disease, microglial activation amplifies disease progression. If this works we will go directly to patients!
Just a reminder that when the British arrived in 1700s, India had 27% of global GDP. But after 200 years of theft and millions starved to death, by 1947 India had 3% of global GDP, 90% living below the poverty line, a literacy rate of 17% and life expectancy of 27. I mourn them.
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Who to follow
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Iannacone Lab
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Megan Orzalli
@VirulentMind -
The Barton Lab
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Berger Lab
@berger_lab -
Andrés Hidalgo
@AndrsHidalgo16 -
Marraffini Lab
@MarraffiniLab -
Rice Lab
@RiceLaboratory -
Elphege Nora Lab at UCSF
@ElphegeNoraLab -
Trends Cell Biology
@TrendsCellBio -
Josefowicz Lab
@JosefowiczLab -
Jesse Engreitz
@jengreitz -
Science Translational Medicine
@ScienceTM -
Developmental Cell
@Dev_Cell -
Rob Klose
@RobKlose -
Trends in Immunology
@TrendsImmuno
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