Lucy Yang
@isolucyineshe/her | PhD candidate @HarvardCCB (Woo Lab) | NSF-GRFP Fellow | B.S. @UCIChemistry ‘22 (Lupták Lab) | chemoproteomics, protein damage, and mass spectrometry
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Congratulations to all the scholars who participated in the @HarvardCCB Chemistry Future Leaders Symposium! #chemtwitter chemistry.harvard.edu/news/ccb-hosts…
Happy first day of the fall semester! Let’s hope no one’s science is going up in flames 🔥 (If it does make sure you have an extinguisher on hand 🤭)
Curious about how protein damage forms the ever-so-elusive C-terminal cyclic imide? Check out our lab’s newest preprint released earlier this month on @biorxivpreprint 🫡 Congrats to all the authors who contributed to this work 🙌🏼
Excited to share our latest preprint on the systematic characterization of C-terminal cyclic imides from protein damage! Read all about how these modifications are formed and regulated by CRBN and why they should not be overlooked. biorxiv.org/content/10.110…
Happy CCB Welcome Back Barbeque Day from the Woo Lab! Had a great time with friends, and we’re especially proud to celebrate our newly tenured boss, Prof. Woo! ✨✨✨
If you liked the versatile TR-FRET methodology we reported in our cyclimid paper, check out our detailed @STARProtocols procedures. We are looking forward to seeing these approaches being (hopefully) broadly adapted! @mazit @drcmwoo & Saki Ichikawa sciencedirect.com/science/articl…
Our newest work in collaboration with Saki Ichikawa and @drcmwoo @mazit is now online @CellChemBiol! Here is a free-to-read link: authors.elsevier.com/c/1iYPc8jWWJxL…
Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17 #1: biorxiv.org/content/10.110… #2: biorxiv.org/content/10.110…
I’m thrilled to share the results from the first project of my PhD! Huge thanks to my co-authors @NeugMonicaElena and @NicholasKrasnow for their contributions and support throughout the project. Very excited to see how the community will use these next-generation base editors!
Today we report in @NatureComms the development of laboratory-evolved CBE6 cytosine base editors that offer high on-target C•G-to-T•A editing, virtually no A•T-to-G•C editing, low off-target editing, broad sequence context compatibility, and compatibility with multiple Cas…
Congratulations to @drcmwoo for winning an ASPIRE Award from the @TheMarkFdn! themarkfoundation.org/2023/11/the-ma… #chemtwitter
Excited for the release of this commentary on ARPLA, the first method that allows us to *see* glycoRNAs on the cell surface!
Fun to see our News & Views out written with @pphristov about the ARPLA method developed by @yuan_ma_ @weijieguoguo and @LuLabUT to visualize #glycoRNAs on single cells
Please join us in welcoming our new faculty member, Dr. Saki Ichikawa! Her research will focus on integrating chemical biology, organic chemistry, and chemical proteomics to explore the intricacies of protein modifications and their impacts on biological systems.
“Ten years ago I was kicked out and forced to retire.” Our new medicine laureate Katalin Karikó (@kkariko) told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges. Ten years ago, Karikó was still doing all her…
BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
Nature research paper: Acetyl-methyllysine marks chromatin at active transcription start sites go.nature.com/3Lvc9KQ
Our paper describing the interaction of multiple protein-targeted drugs with cellular RNAs has appeared in Nature Chemistry - the study used acylation to trap drugs on RNAs doi: 10.1038/s41557-023-01309-8
Great to see this work published. Another wonderful example of how proximity-based therapeutics can be used in so many ways. In this case, creating new PPIs to block functional PPIs…steric blocking glues science.org/doi/10.1126/sc…
Awesome paper from Jack Taunton’s lab @UCSF on direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes using chemoproteomics! nature.com/articles/s4155…
My daughter drew a cancer cell dying and HANG IT IN THE LOUVRE
10/10 in method naming
1/10📢Thrilled to announce our new preprint! In this work, we describe a new method called TREX for unbiased discovery of proteins that directly bind to a given region of an RNA of interest. And all this is from living cells under endogenous settings! #RNA biorxiv.org/content/10.110…
This week in Nature: Shining example - Fluorescent mimic sheds light on DNA's 3D folding capabilities Browse the current issue: nature.com/nature/volumes…
I just can't today. we keep moving backwards.🤦♂️ corrective biases = bad thinly veiled biases = good why's that?
Before you begin your thinkpiece, the Supreme Court DID NOT strike down Affirmative Action Admission preferences for legacies, donors, employee families and special recommendations are still allowed The Court struck down Affirmative Action For everyone except WHITE PEOPLE
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