Ueda HH
@hueda0718Ph.D / DVM / 無職 #Synbio #ProteinEngineering #Neuroscience #VeterinaryMedicine
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@tyuys
@rirumariruri
@yutamshita
【対談企画始動！】 とある教授のもとに夜な夜な研究者たちがあつまり 科学談義に花を咲かせているらしい さてさて、今宵はどんな話を聞かせてもらえるのだろう・・ 初回のゲストは吉村由美子先生 子供の頃の話から、生理研との出会い、研究のお話しなど、お楽しみ下さい♪ youtu.be/lu6WdGQHfpQ?si…
\\ブルーバックスYouTubeスタート// きょう！さきほど！YouTubeを始めました！ 超初心者です🔰🔰 チャンネル名は「ブルーバックスチャンネル」 初回は天才科学者 野村泰紀先生に 最先端の宇宙論について聞きました👇 youtu.be/jvKmtywmGoU?si… #ブルーバックス #宇宙 #野村泰紀…
Here is the Alphafold3 prediction. It is worse than random. High false positive and high false negative (iPTM/PTM shown - other metrics look very similar). 4/n
Excited to share that the AlphaFold 3 model code and weights are now available for academic use. Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmin… 1/2
ついに来たか 拡散言語モデル!
🌟 Excited to share our latest work on making diffusion language models (DLMs) faster than autoregressive (AR) models! ⚡ It’s been great to work on this with @caglarml 😎 Lately, DLMs are gaining traction as a promising alternative to autoregressive sequence modeling 👀 1/14 🧵
おおお！！！ ｢スマート･インスリン！｣ Nature ･ 血糖値に応じて自動的にオンとオフを切り替えることができる新しい形のインスリンを開発 ･ 動物実験では、この「スマート｣インスリン は、血糖値が低くなりすぎるのを防ぎながら、高血糖濃度を効果的に下げた doi.org/10.1038/s41586…
生細胞内における微小管の新規イメージング法開発 AlphaFold2を駆使してループ内にsplit-GFPの断片を組み込んだチューブリンを設計 元々の微小管の機能を損なわず、胚発生中、線虫成体内、哺乳細胞内など様々な場面で微小管のダイナミクスを可視化できた #BNTNJC journals.plos.org/plosbiology/ar…
Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. @befcorreia @sokrypton biorxiv.org/content/10.110…
1/ 12 years ago, I typed my first "Hello world!". It is not easy to learn bioinformatics from scratch. But it is possible if you put in effort and have a clear pathway.
もうでかいVRAMに高い金を払う必要は無くなるかもしれないのか?超分散LLM推論環境が爆誕 ｜shi3z @shi3z #note note.com/shi3zblog/n/n2…
We’re excited to partner with @adaptyvbio & @_DimensionCap to run a 2nd round of binder designs for EGFR! Weren’t happy with the latest results? Didn’t get to participate? Now’s your chance! In round 2, the same rules apply, but this time you’ll have access to the newly…
Designing better cancer therapeutics using AI - Round 2! 🧬 In Round 1 of our competition, 90 designers submitted 700+ protein designs with the goal of developing a new therapeutic by blocking a cancer-associated receptor called EGFR. 🔎 We then validated 200 proteins in our…
I apologize if our previous preprint post was taken as if the original results were irreproducible. The skin clearing was reproduced. Although other issues remain, we decided to retract our preprint. I apologize to @HongNeuroTech and the community for the confusion.
Check out our new bioRxiv preprint that challenges the recent in vivo optical clearing paper with tartrazine dye in Science. To be clear, they only demonstrated optical clearing of *dead cells*. Tartrazine cannot make live tissues transparent doi.org/10.1101/2024.0…
Why are some neurons more selective than others? We report now in @Nature how calcium permeable-AMPA receptors in PV neurons make them less selective to sensory features nature.com/articles/s4158… Long live the geniuses behind this🧠🔍juhyun.kim @thainmueller @rhuganir
The first episode of @BakerLabPodcast is live. Meet Mohamad Abedi, who went from being a Palestinian refugee to a postdoctoral researcher. His journey proves that science can be a creative and transformative process. Apple: podcasts.apple.com/us/podcast/the… Spotify: open.spotify.com/show/32pWWpKzO…
"We used a CaMKIIa promotor to exclusively target excitatory neurons"
前屈型の頚部ジストニア（痙性斜頸）に対するハンガー反射デバイスで完治した私達の論文が公開されました。小原先生の研究論文です。私達はこのような非侵襲型治療にも取り組んでいます。bit.ly/3zwBTny #頚部ジストニア #痙性斜頸 #ジストニア #ハンガー反射 #dystonia #hanger #reflex
今日の外来の奇跡。4回の手術をしても改善が困難な眼瞼痙攣の患者さんにハンガー反射の器械をつけたところ劇的な改善。これは非侵襲的に眼瞼痙攣を治療する全く新しい概念の治療になります。眼科医はきっと信じないでしょう。学術論文になれば結果を公開します。#眼瞼痙攣
![Chem-Station（ケムステーション；ケムステ）は日本最大化学ポータルサイト。化学の話題をつぶやきます。化学好きの方フォローお願い致します。2017年度日本化学会化学教育賞・2019年文部科学大臣表彰科学技術賞受賞 [化学][ニュース][分子][Chemistry][News][Molecule]](https://pbs.twimg.com/profile_images/1456030429/chemstation.png)
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