Cian O'Donnell
@cian_neuroComputational neuroscientist at Ulster University. he/him
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btw one v nice feature on Bluesky is the user-made 'starter packs', suggested lists of who to follow. Eg here is one of computational neuroscientists: go.bsky.app/7VFUkdn
Bluesky and mastodon both great alternatives to this place. Bluesky neuro community in particular is growing rapidly now. Even a few classic-neurotwitter-style beefs emerging 🍿 I'm at bsky.app/profile/cianod… and mstdn.science/@cian
Bluesky and mastodon both great alternatives to this place. Bluesky neuro community in particular is growing rapidly now. Even a few classic-neurotwitter-style beefs emerging 🍿 I'm at bsky.app/profile/cianod… and mstdn.science/@cian
I'm leaving here for the foreseeable future. Sad for what has happened to this place. The once and future hope is that mastodon can carry the torch. If you join there I'm @cian@mstdn.science
Writing is thinking. This is an absolute verity. Writing is not the transcription of thinking, it is itself a fundamental and unique process of thought. When a good sentence ends, its author knows more than when they began it. AI should be evaluated in this context.
Mammalian cells express >1000 types of microRNAs. Almost all rely on the enzyme Dicer for maturation. How might competition for this shared resource affect the profile of microRNA expression? We (mainly @RaakSofia) studied this in a computational model. biorxiv.org/content/10.110…
Never thought I would see the Northern Lights for myself, now here they are outside my front door.
Our paper is finally out (my first published first author)! In a tau model, we saw changes in signal encoding in vivo in tandem with synapse and structure alterations. A full summary in the qt below or go read the paper if you’re interested! academic.oup.com/braincomms/art…
So finally my first ever (!!!) first author is out into the world of BioRxiv summarising my PhD work - Synaptic alterations associated with disrupted sensory encoding in a mouse model of tauopathy. Twitter 🧵 below biorxiv.org/content/10.110…
I found this fascinating: newyorker.com/magazine/2024/… The question it raised in my mind is whether psychiatric categories satisfy a need which can't be satisfied any other way. Is some critical aspect of personal identity lost if dimensions supplant categories?
AlphaFold 3 is out! As expected expands coverage to small molecules and nucleic acids. And replaces the structure module with a diffusion-based one. Unfortunately no code or model weights--just a web server for a limited set of ligands: blog.google/technology/ai/…
FWIW, at @PLOSBiology we would've *insisted* on the code; otherwise, as you say, no point in publishing it. Without the code it is nothing.
delighted our latest paper reached its final form - incredible job from @DrSorayaM showing with biochemistry, anatomy, slice & in vivo whole cell recordings how synaptic changes coincide with altered sensory coding in cortex of mice affected by #tauopathy academic.oup.com/braincomms/art…
Giving a talk on this work with @neuro_kim at #ICLR2024, Tuesday 10 AM for oral session 1A! We relate deep RL representation learning to multi-region computations in the brain. Our poster will be right after the oral session. Come say hi 😀
Excited to share a new paper with @neuro_kim: “Predictive auxiliary objectives in deep RL mimic learning in the brain”, which has been accepted as an #ICLR2024 oral and #Cosyne2024 talk! openreview.net/forum?id=agPpm…. A short summary:
Increasingly I feel that academics self-organise themselves not primarily by 'topic of interest' but rather 'epistemology'. Different fields and subfields have different assumptions about what is useful knowledge and how it is acquired 1/2
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