Frank Huang
@frankhuangmdMD/PhD Candidate @hi_stem_lab & @DKFZ interested in hematological malignancies
Previous studies have shown self-reported Black patients have inferior treatment and survival outcomes compared to White patients, but why? Our work indicating that underlying genetics influence AML biology is now live at @NatureGen! 🎉🎈🍾 nature.com/articles/s4158…
Origins of de novo chromosome rearrangements unveiled by coupled imaging and genomics biorxiv.org/cgi/content/sh… #biorxiv_genomic
On bioRxiv today, we raise serious concerns over a recent @nature paper describing ReDeeM, a new single-cell mitochondrial DNA (mtDNA) sequencing / analysis method. Here are three things that you need to know: 1/n biorxiv.org/content/10.110…
Excited to share: Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging: Cell Stem Cell cell.com/cell-stem-cell… Huge privilege to work colleagues in the lab and with Andy, Stephanie and John
I am so very excited to share that my PhD work exploring somatic structural variation in healthy human HSPCs has now been published in @NatureGenet! So grateful to everyone involved for their hard work. nature.com/articles/s4158… A short 🧵 on our findings in this fun project:
Today we are thrilled to share our approach to selectively eradicate haematological cancers while preserving healthy haematopoiesis. Goal: corner cancer. Full story here: nature.com/articles/s4158… Here’s a breakdown of our findings:
Very excited (& nervous) to share what we've been working on the past many years. Only took 3 first authors (Schreuder the experimentalist, @DawnSLin the analyst, and @syzmath the modeller) & co-senior Weber (computational, modeller, SynBio extraordinaire) biorxiv.org/content/10.110…
This represents how we believe haematopoiesis is actually proceeding at a clonal level. I'll walk through our preprint early next week. "A multi-track landscape of haematopoiesis informed by cellular barcoding and agent-based modelling" biorxiv.org/content/10.110…
Fantastic to have our paper "Deciphering cell states and genealogies of human hematopoiesis" published today in @Nature as an Accelerated Article Preview! We describe ReDeeM! Awesome work led by @chenweng1991 in a wonderful collaboration with @JswLab! nature.com/articles/s4158…
We are recruiting!!! HI-STEM is seeking to appoint an Independent Junior Research Group Leader to develop an internationally competitive research program. More information below and on our website (hi-stem.de/about-us/jobs). Application deadline is February 22nd, 2024!
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