Sanjeeva Reddy Dodlapati
@dodlapati_reddyPhD @oducs AI for epigenomics & precision medicine. MSCS @GeorgiaTech. MS Chemistry @UofNO. Calls out hypocrites. “SATYMEVA JAYATE” 🇮🇳 తెలుగు భాషాభిమాని
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To make our fantastic CITE-seq data set of postnatal thymocytes accessible to the community, we have launched a shiny web app for interactive exploration. Go check it out! ccgg.ugent.be/shiny/htsa_thy… Moreover, scRNA-seq and Visium spatial data can be found at cellxgene.cziscience.com/collections/fc…
Also check out the rest of the #HumanCellAtlas paper collection including insightful perspective articles: nature.com/collections/jc… @NaturePortfolio
Accurate RNA 3D structure prediction using a language model-based deep learning approach nature.com/articles/s4159… #journals #feedly
We're happy to announce the addition of knowledge distillation to torchtune, a PyTorch library for easily authoring, fine-tuning & experimenting with #LLMs. Check it out: hubs.la/Q02YyqDG0 Distilling Llama3.1 8B into 1B in #torchtune
This is called innovation in India 🤣
Nanopore approaches for single-molecule temporal omics: promises and challenges nature.com/articles/s4159… #journals #feedly
Deep learning-based models for preimplantation mouse and human embryos based on single-cell RNA sequencing nature.com/articles/s4159… #journals #feedly
Detection and analysis of complex structural variation in human genomes across populations and in brains of donors with psychiatric disorders cell.com/cell/fulltext/… #journals #feedly
Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors: Cancer Cell cell.com/cancer-cell/fu…
A fantastic read about elite universities in the US: “Family life changed as parents tried to produce the sort of children who could get into selective colleges. Over time, America developed two entirely different approaches to parenting.” 1/35
“If you control the choke points of social mobility, then you control the nation’s culture. And if you change the criteria for admission at places such as Harvard, Yale, and Princeton, then you change the nation’s social ideal.” theatlantic.com/magazine/archi…
Another wonderful work showing fundamental flaw existing in many if not all dna-lm papers -- all current dnalm "superior performance" comes just from weak supervised baselines used It should be noted, however, that authors make one mistake by coping results from NT paper.
🧵 on surprising revelations from our study of specialized foundation models (FMs beyond vision/text): after evaluating dozens of scientific & time series FMs we found that most weren’t even competitive with simple supervised models, some with as little as 513 parameters. 1/n
🚨 Very happy to announce the publication of my PhD work @NatureBiotech where we combined base and prime editing screens to investigate the impact of genetic variants in cancer. 🧵⬇️ nature.com/articles/s4158…
Empowering Biomedical Research with AI Agents: A New Era of Discovery open.substack.com/pub/sanjeevare…
Discover how BioNumPy enhances biological data analysis by integrating NumPy's array programming with bioinformatics tools. medium.com/@sdodl001/bion…
Unlocking the role of uncertainty in genetic variant predictions: Dive into how understanding and quantifying uncertainty can enhance the reliability of genomic models for personalized medicine medium.com/@sdodl001/unra…
I just published Unraveling Uncertainty in Genetic Variant Predictions with Deep Learning link.medium.com/l1ZDU6IgdOb Check out and make suggestions for further improvement :)
📢🧬Looking for fast and reliable ways to predict binding affinities? Meet BALM!👋 BALM predicts binding affinity from protein sequences and ligand SMILES using pretrained protein and ligand language models. 📄 doi.org/10.1101/2024.1… 🔗 github.com/meyresearch/BA… 🧵1/9
Out in @NatureComms ! ChromaFold predicts 3D contact maps using single-cell ATAC-seq alone. nature.com/articles/s4146…
Accelerated bisulfite sequencing detects 5-methylcytosine in low-input DNA and RNA samples go.nature.com/3H1zWPY rdcu.be/dXH1y
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