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@CoxAaronR
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Congratulations to Team Inceptor
Probably the greatest finding of our lab 😀 Very proud of my team and very thankful for all collaborations! disq.us/t/3uhaj0q">disq.us/t/3uhaj0q N&Vs: New-found brake calibrates insulin action in β-cells nature.com/articles/d4158… read here: rdcu.be/cejlQ disq.us/t/3uhaj0q">disq.us/t/3uhaj0q
Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in @Nature Here we identify a single receptor that can both peripherally increase energy expenditure and centrally suppress appetite. nature.com/articles/s4158… 1/12 🧵👇
NNC2215, an insulin conjugate with a glucose-binding macrocycle and a glucoside, creates a glucose-sensitive switch that reversibly responds to ambient glucose levels, potentially reducing hypoglycaemia risk in diabetes treatment. nature.com/articles/s4158… #NBThighlight
Proteomic predictors of individualized nutrient-specific insulin secre... sciencedirect.com/science/articl… is the latest work from star fellow (and current faculty job hunter) Dr. Jelena Kolic @JelenaK86
🚀Excited to share our latest work in @LickertHeiko lab: "Resolving human α vs β cell fate allocation for generating stem cell-derived islets." Thanks to the amazing contributions from @LamaSaber95, @EunikeSetyono, and @TobiasGreisle! Read more here: doi.org/10.1101/2024.0… 1/
.... and following up on my previous post, I am pleased to share our article online today @TheLancetEndo Full text available (next 50 days) via this link through Elsevier url.au.m.mimecastprotect.com/s/fgPkCyojKztW…
Terrific work!!!
Thrilled to share our work “A multimodal cross-species comparison of pancreas development”. doi.org/10.21203/rs.3.… A tremendous collaborative effort led by @Carina_K_YANG & @HannahSpitzer1, and other members of @LickertHeiko @fabian_theis, Eckhard Wolf labs.
Extremely happy to see this great cooperation with @TimoMueller_IDO and @MatthiasTschop published in @NatMetabolism The Inceptor story continues and stay tuned, as we also found a ligand 😉 hopefully published very soon as well…
Promising Results for Causal #Diabetes Therapy By knocking out the #insulin-inhibitory receptor 'inceptor', #HelmholtzMunich scientists & colleagues found an enhanced glucose regulation. This makes inceptor a prospective drug target for #type2diabetes: 👉t1p.de/cnd99
Insightful work from our @helmholtz_diabc colleagues @LickertHeiko @TimoMueller_IDO @MatthiasTschop et al corroborating Inceptor as key mediator of IGF1R & INSR signaling in diet induced obesity - validating Inceptor as promising therapeutic target 👍🎇🎉nature.com/articles/s4225…
More β cell heterogeneity, with RRβs as a subpopulation of β cells that make a disproportionally large contribution to biphasic GSIS from mouse #islets @NatMetabolism #insulin #diabetes nature.com/articles/s4225…
Excited to share our new manuscript @MolMetab This study led by @CAMBUpenn graduate student Libby Nunn explores the potential of activin type II receptor blockade to maintain muscle mass and enhance fat loss during GLP1RA in obese mice sciencedirect.com/science/articl…
1/ Thrilled to share our latest research on the role of insulin in human endocrinogenesis, led by @pacotael Thanks to @LickertHeiko @ozumsehnaz @NatalieKrahmer @AimeeBastidas @Diana61204366 @LamaSaber95 and others involved. sciencedirect.com/science/articl…
Our latest work on the function of NEUROD2 during human endocrinogenesis. Led by @pacotael and @LamaSaber95 Thanks to @LickertHeiko @Diana61204366 @AimeeBastidas and others involved. frontiersin.org/articles/10.33…
Many immune evasion strategies to protect SC-islets from transplantation rejection employ CD47 overexpression, while this new paper suggests CD47 negatively impacts beta cell function. Clearly many of such strategies warrant more detailed studies. science.org/doi/10.1126/sc…
Our recent review article describing "Mitochondrial regulation in human pluripotent stem cells during reprogramming and β cell differentiation " is now out. Check it out here below 👇 #iPSCs #SCIslets #Diabetes #StemCells #CellTherapy frontiersin.org/articles/10.33…
To get a quick sneak-peak into our recent mouse islet atlas (MIA) paper, here is the research briefing: nature.com/articles/s4225….
Come join us! Our Biochem Dept is a fabulous place to build a career! Top-notch science, supportive colleagues, world-class facilities, and exceptional trainees! Pls help spread the word. Feel free to ping me with Qs, I am the search co-chair
Another great @LickertHeiko and @fabian_theis cooperation. Kudos to @KHrovatin as main driver with great help of @AimeeBastidas, @bakhti_mostafa, @_lazappi_, @AnikaBoettcher , @marenbuettner , @CiroSalinno and @AdrianaMiglior1
To ease understanding of diabetes, which is complicated by bio and technical factors affecting the regulators of blood glucose – the pancreatic islets, we created a comprehensive mouse islet atlas (MIA) by integrating multiple single-cell transcriptomic (scRNA-seq) datasets.
Single Cell RNA-Seq Analysis of Regenerative Drug-Treated Human Pancreatic Islets Identifies A Cycling Alpha Cell Population As Key Beta Cell Progenitors biorxiv.org/cgi/content/sh… #bioRxiv
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Who to follow
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Aaron Cox, Ph.D.
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Maike Sander & Lab
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Mostafa Bakhti
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Cristina Aguayo-Mazzucato
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