@alvaldeolivas Profile picture

Alberto Valdeolivas

@alvaldeolivas

Scientist in #bioinformatics @Roche. Physicist, Biological networks, System Biology, Spatial Omics, Cancer

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Alberto Valdeolivas Reposted

Check the latest @DR_E_A_M paper, evaluating methods to deconvolve cellular composition from bulk gene expression, with contributions from our (former) @alvaldeolivas & @JulioSaezRod 👇

Paper is out! Deconvolve cellular composition from bulk gene expression nature.com/articles/s4146…



Alberto Valdeolivas Reposted

New publication: The Molecular Landscape of Premature Aging Diseases Defined by Multilayer Network Exploration @cecilebeust @alvaldeolivas @AnthBaptista Galadriel Brière, Nicolas Lévy, @OzisikOzan @BaudotAnais doi.org/10.1002/adbi.2…

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Hello! We're seeking an intern or master's student for a 6-month exploratory project in spatial analysis. Please share or apply! 😀 careers.roche.com/global/en/job/…


Alberto Valdeolivas Reposted

If you like MISTy doi.org/10.1186/s13059…, you'll really like Kasumi doi.org/10.1101/2024.0…. Kasumi is a multi-view explainable representation learning approach, capturing localized relationship-based patterns in tissues across conditions aiming towards facilitating translation

Local heterogeneity of tissues can define their function and predict clinical outcomes. We introduce Kasumi 💻biorxiv.org/content/10.110… to identify spatially localized neighborhoods of intra and intercellular relationships from spatial omics persistent across samples & conditions

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Alberto Valdeolivas Reposted

Finally out a new paper from the lab lead by @TrimbourR "Molecular mechanisms reconstruction from single-cell multi-omics data with HuMMuS" doi.org/10.1093/bioinf… #singlecell #multilayernetworks

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Alberto Valdeolivas Reposted

Local heterogeneity of tissues can define their function and predict clinical outcomes. We introduce Kasumi 💻biorxiv.org/content/10.110… to identify spatially localized neighborhoods of intra and intercellular relationships from spatial omics persistent across samples & conditions

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Alberto Valdeolivas Reposted

The molecular landscape of premature aging diseases defined by multilayer network exploration @cecilebeust @alvaldeolivas @AnthBaptista @OzisikOzan @BaudotAnais medrxiv.org/content/10.110…

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Alberto Valdeolivas Reposted

New #preprint We investigated the hypothesis that genes associated with different muscular dystrophy onsets code proteins with distinct cellular functions, using computational approaches. @SGorokhova @MatCerino @Myologie_MMG @anais

System-level analysis of genes mutated in muscular dystrophies reveals a functional pattern associated with muscle weakness distribution biorxiv.org/cgi/content/sh… #biorxiv_bioinfo



Alberto Valdeolivas Reposted

New #preprint The molecular landscape of premature aging diseases defined by multilayer network exploration @cecilebeust @alvaldeolivas @AnthBaptista Galadriel Briere, Nicolas Levy, @OzisikOzan @BaudotAnais

The molecular landscape of premature aging diseases defined by multilayer network exploration medrxiv.org/cgi/content/sh… #medRxiv



Alberto Valdeolivas Reposted

📣 Introducing LIANA+: an all-in-one cell-cell communication (CCC) framework 🧬 Many tools exist, yet they use various syntaxes and are tailored for a specific purpose LIANA+ harmonises and extends existing methods, enabling their synergistic applications tinyurl.com/lianaplus

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Alberto Valdeolivas Reposted

🧪 LIANA+ is an #OpenSource #Python framework, available on GitHub: github.com/saezlab/liana-…, with extensive #singlecell and #spatial tutorials: liana-py.readthedocs.io Beyond re-implementations, our framework includes new methods and amplifies insights:


Alberto Valdeolivas Reposted

🗺️ Navigating #SpatialOmics: LIANA+ empowers Spatial Analyses. Uncover intricate spatial relationships from global multi-view modelling to fine-grained local metrics @YuanhuaHuang @shazanfar @MarioniLab

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Alberto Valdeolivas Reposted

Very happy that this is now out.🔥 Many thanks for everyone involved, and to all the developers! 💻 We will keep working on making LIANA+ as robust, user-friendly and extensive as possible!🎯

📣 Introducing LIANA+: an all-in-one cell-cell communication (CCC) framework 🧬 Many tools exist, yet they use various syntaxes and are tailored for a specific purpose LIANA+ harmonises and extends existing methods, enabling their synergistic applications tinyurl.com/lianaplus

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