Abramson Lab
@TheAbramsonLabLab at the Weizmann Institute of Science interested in Thymus biology | Immunological tolerance | Autoimmunity | RoryT APCs | sexual dimorphism of immune system
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Excited to share our latest @Nature paper spearheaded by @YaelGruper identifying a new autoimmune disorder, characterized by impaired tooth development & generation of autoAbs against enamel matrix. It occurs in most AIRE def patients & ~1/3 of celiac kids nature.com/articles/s4158…
Happy to see our story on tolerance to inflammation antigens @NatImmunol nature.com/articles/s4159… It grew from a naive question I had at my first immunology class: if some self molecules are only induced by pathogen how does immune system distinguish them from foreign antigens?1/n
In this study, interferon-γ was found to play a large role in the pathogenesis of APS-1. Results were confirmed in studies in animals and led to a trial of ruxolitinib in five patients, who had dramatic responses. Read the full study results: nej.md/4bXoKkG
Congratulations to Prof. Jakub Abramson @TheAbramsonLab of the Immunology and Regenerative Biology Department and to Drs. @SegevEinat and @filipenatalio of the Plant and Environmental Sciences Department upon receiving the @ERC_Research 2023 Proof of Concept Grant #ERCPoC
The thymus can regenerate after acute injury due, in part, to the actions of local type 2 innate lymphoid cells (ILC2s), suggests a new study in mice. @WeizmannScience 📄: scim.ag/5wr
Very happy to share our latest @SciImmunology paper spearheaded by Shir Nevo uncovering the role of thymic fibroblasts and tuft cells in thymus regeneration upon acute injury science.org/doi/10.1126/sc…
Congratulations to @HonzaDobes87 for being awarded the FGS prize for outstanding achievements in postdoctoral research!
Thymus regeneration upon glucocorticoid-induced acute involution is orchestrated by IL-25– and IL-33–dependent activation of ILC2 @SciImmunology science.org/doi/10.1126/sc…
Could the consumption of milk lead to dental problems in some children? New research led by Prof. Jakub Abramson and his team has uncovered a new autoimmune disorder that affects the development of tooth enamel and is prevalent among children with celiac disease. While many…
Our @medrxivpreprint is open for public comment. We describe the experience of people reporting a chronic post-vaccination syndrome (PVS) after covid-19 vaccination. We are following the science. @VirusesImmunity @React19org @YaleMed @YaleCII medrxiv.org/content/10.110…
New paper out today in @jclinicalinvest! A new splice mutation of Aire that skips exon 7, shows a correlation between Aire function and degree of disease. Ex7splice retains some function, giving milder disease phenotype in compared to recessive variants jci.org/articles/view/…
In @JExpMed, @Brabec_Tomas_, @SchwarzerGnoto, @TheAbramsonLab, @FilippLab, @HonzaDobes87 et al. show that segmented filamentous bacteria induce the conversion of cognate CD4+ T cells to cytotoxic intraepithelial lymphocytes. bit.ly/3tQJSbM @science_charles
We are very happy to share our lates publication in @Nature, spearheaded by Tal Givony &Yael Goldfarb, expanding the incredible cellular & functional diversity of mTECs and bringing key insights into the roles of thymic microfold and endocrine cells nature.com/articles/s4158…
Applications for the 2024-25 Azrieli Int’l #Postdoctoral #Fellowship are OPEN! Apply by Nov 15 to be considered for a postdoc position at a top academic institution in Israel – available to candidates worldwide. Learn more: bit.ly/3YSBmV7 #CallforApplications
NEW Review: The emerging family of RORγt+ antigen-presenting cells bit.ly/3OtuSbP by Greg Sonnenberg @TheAbramsonLab @MengzeLv @HonzaDobes87 summarizes the major findings that led to their discovery and discusses discordance in recent reports
dlvr.it/SsXgH8 I am very privileged to write this @NatRevImmunol review on RORγt+ APCs together with G Sonnenberg @MengzeLv @HonzaDobes87 We review their history, molecular & functional complexity, while also highlighting existing unknowns and future perspectives
Congratulations to @CYImmunologists for organizing a fantastic mixer event and for kindly inviting me to be part of it. So happy to see Czech immunology blossoming again…
A well deserved break from the lab :) Had an incredible time together in the lowest place on earth 🌍 Thank you @IRB_Department for a great retreat!
Congrats to @YaelGruper our incredible PhD student for presenting her novel study on tooth autoimmunity!👏😎
It was such an honor to be able to present my data at this amazing conference! #cshlimmune @cshlmeeting @TheAbramsonLab
What a privilege to be in the company of one of the most brilliant politicians of the 20th century and one of the most brilliant scientists of the 21st century @DMSabatini in one of the most beautiful cities in the world!
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Who to follow
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The Immunology and Regenerative Biology Department
@IRB_Department -
Moshe Biton
@bitonm -
jana.balounova
@balounova_jana -
Daniel Vašek
@Dan_Vasek -
Ranit Kedmi
@KedmiRanit -
Systems_Immunology_WIS
@Sys_Immunology -
Filipp Lab
@FilippLab -
Czech Immunological Society
@immunsociety_cz -
Jan Dobeš
@HonzaDobes87 -
Veronika Niederlová
@vercanie -
Irit Sagi
@irit_irit -
Ondrej Stepanek - Lab of Adaptive Immunity
@AdaptiveImmuni2 -
Czech Young Immunologists
@CYImmunologists -
Montaser Haddad
@haddad_montaser -
Matouš Vobořil
@matous_voboril
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