Tan Yong Chiang (Aleks)
@TanYongChiangBioinformatics | PhD Candidate | Muay Thai
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Ever wondered how biological neurons compute? The Hodgkin-Huxley equations reveal how membrane voltage and ion channels orchestrate the information processing. This model is considered by many to be the most important equation in all of neuroscience 🧠 In the new video we will…
Mixtures of engineered bacteria were able to: - Identify if a number is prime - Check if a letter in a string is a vowel - Determine the max number of pieces of a pie obtained from n straight cuts. Answers are printed by expressing fluorescent proteins in different patterns.
5 years later, my ideology remains the same. Though many colleagues still relies on assumptions & indirect inferences. ◼️Much is yet to be accomplished. The fruits of @slavovLab efforts to increase accessibility: scp.slavovlab.net
As single-cell mass spec proteomics scales in throughput, depth & plex-ing, we need protocols to match. Our latest protocol was just published in @NatureProtocols nature.com/articles/s4159… OA link: rdcu.be/dQlI1 We demonstrate over 1,000 single-cell proteomes / day.
Traditional cancer research delineates one start and one end. With single cell omics, we're going to see more on the sequences happening in between.
Our opinion piece is out today, "The origin of novel traits in cancer"! Do the phenotypes come first and only later are they locked in by genetic or epigenetic changes? Insights from evolutionary biology are super useful for understanding cancer! cell.com/trends/cancer/… #S_Frank
A protein regulates its RNA. As nascent tubulin polypeptides emerge from the ribosome exit tunnel, they are recognized by TTC5, which ultimately leads to RNA degradation. How common is this mechanism ? How many proteins regulate their transcripts ?
Excited to share our #MultiRegion #SingleCell dissection of #Alzheimers out in @Nature today studying #Reelin in #RegionSpecific #NeuronalVulnerability, #CholineMetabolism and #PolyAmineBiosynthesis in #CognitiveResilience, #Astrocyte diversity, #Thalamus-specific #Interneurons,…
Very nice preprint from @OConnor_lab on medicinal plant iboga. Things I found interesting: 1) multi-gene constructs outperformed single-gene constructs co-infiltration; 2) expressing iboga enzymes in Catharanthus petals led to iboga specific metabolites. biorxiv.org/content/10.110…
Are computational biologists the drivers of research? 7 years ago I co-wrote an editorial about how computational biologists are no longer just supportive, but are now running the show. Today I would write how every biologist should also be computational. genomebiology.biomedcentral.com/articles/10.11…
Someone claimed this figure was published in @NatureRevGenet I did not believe them. I was wrong.
My old advisor always told me: "try to make experiments that either results will give you a sense of what is going on."
My rules for academia: 1. there are many paths to success, look for your own, 2. if the project excites you, do it; if it doesn’t, don’t. 3. let the project change, that’s what it’s supposed to do, 4. review the work of as you’d want to be reviewed, 5. one sentence, one idea.
An untaught but important rule for thriving in academia is ‘strategic synergy’ (or ‘two birds with one stone’). Need to give a talk on something? Use it as a practice for another presentation. Need to write a grant progress report? Use it as a draft for a review you are writing.
2h of debugging. Whatever you say, that's counter intuitive.
【拡散希望】新たな研究成果「A Protein Language Model for Exploring Viral Fitness Landscapes」をbioRxivに公開しました！🦠💻 本研究では、新型コロナウイルス変異株の適応度（伝播力）をSタンパク質配列から予測するタンパク質言語モデルCoVFitを開発しました。1/n biorxiv.org/content/10.110…
Simulate the central dogma in a browser!
UMAP was introduced to biology data with the argument that it 'preserves the global structure of the data' better than t-SNE. This claim was falsified in a matters arising article. 1/2
How do you write a strong & compelling research article? I distilled guidelines that I find useful to share with @slavovLab Then, I decided to share them more broadly. Writing well helps, but it's not just about writing. blog.slavovlab.net/2024/02/12/com…
Don't ask flowers to grow. ◼️ Water them, and they will grow. 🌺 Don't ask your team to work. ◼️ Help them be their best, and they will excel. 🚀
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