Roger Vargas Jr
@RogerVargasJr2Computational Biologist @moderna_tx - previously Scientist & PhD in TB genomics both @harvardmed 🐄 @WilliamsCollege ‘16 & 🍻 enthusiast. all views my own.
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My favorite chapter of PhD dissertation was just published, 3.5 years in the making! In the early days of quarantine, I became obsessed with capturing as much genetic variation in the MTBC genome as possible, and we observed something odd happening with the acquisition of INDELs
Read our latest study on phase variation in MTBC. We focused on phase variation that results from rapidly acquired indels in simple sequence repeats. These indels can toggle a gene ‘on’ or ‘off’ through frameshifts or dial-up or down transcription. 1/2 pnas.org/doi/10.1073/pn…
scientist after sequencing lots of single cells
When doing computational modeling on genomes, it's easy to ignore anything that's not a SNP. @RogerVargasJr2 shows that phase variation - rapid expansion or deletion in simple sequence repeats - is an important diversity generating process in M. tuberculosis complex
Read our latest study on phase variation in MTBC. We focused on phase variation that results from rapidly acquired indels in simple sequence repeats. These indels can toggle a gene ‘on’ or ‘off’ through frameshifts or dial-up or down transcription. 1/2 pnas.org/doi/10.1073/pn…
Very cool collaborating with @EdHuttlin and others at the CCB on this project! If you’re interested in getting tons of data on protein-protein interactions or just you want to check to see if some of your favorite human proteins interact and are a fan of Python/R, see below👇🏽
Would you like to use @HMSBioPlex data in your bioinformatics analyses? Now there's a package (or two) for that! For details, see our brand new tech note on BioPlexR and BioPlexPy to access our data in R and Python. buff.ly/3I6MoOx
Maybe now that you own this platform you can help fix the gender imbalance the 2nd photo reveals
in honor of the upcoming holiday season, don’t forget about the students that will work through it 🦃🎄🥳🥹🥳 #phd #phdlife #gradschool #ilovephd (credit goes to @Guan_Wang921 on this one capturing the charming @TPnavarrete)
If you’re at #bioc2022, don’t miss today’s talk at 9 AM PDT/12 PM EDT by Ludwig Geistlinger: BioPlexR and BioPlexPy: Integrated Data Products for Analysis of Human Protein-Protein Interactions
Some exciting insights from @AnnaGGre ‘s latest work!! We know of certain mutations that evolutionarily follow drug resistant mutations in MTB (“compensatory” mutations), but what other patterns of dependent mutations are there for this bug? Read below to found out👇🏽
Excited to preprint this piece of work from my postdoc, where we studied dependent mutational events in Mycobacterium tuberculosis complex (MTBC). Thread (1/n) biorxiv.org/content/10.110…
10 years ago I got rejected from my dream college #mit. Turns out it was for the best. 6 years ago MIT rejected me again for grad school - turns out that was also for the best. Happy #PiDay everyone 🥧 Go #ephs 💜💛 - go #crimson ❤️
We really did have everything, didn’t we?
New Englanders on their way to get an iced Dunks today
Hoping for an excellent 2022! We have a new NIH grant on TB vaccines with the focus on engaging CD8 T cells and are looking for a new postdoc. Please DM me or email me at joanne@pitt.edu or philana.lin@chp.edu #tuberculosis Come and join our happy crew in Pittsburgh! RT pls?
Congrats to @RogerVargasJr2 @stefan_niemann @MahaFarhat for this publication!
Postdoctoral fellow pathogen genomics, epidemiology and evolution with @MahaFarhat Harvard Medical School, Boston, USA jobrxiv.org/job/harvard-me… #ScienceJobs
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