Nadia Hameed, MD
@NadiaUSAMCPhysician, GYN Pathologist, Assistant Professor, UT-MD Anderson Cancer Center
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I am happy to announce that our GME office has approved a 2nd position for a GYN Pathology Fellowship at MDACC. If you are interested pls contact me. Start date is July 2024. I’m aware this is on short notice but it is a great opportunity to work with expert GYN Pathologists.
Unusual case. History: Endocx adenoCa in-situ. Developed an ovarian mass simulating an adenofibroma with very few glands in a fibromatous stroma, some without epithelial stratification. Fortunately we did HR HPV. Diag: Mets endocervical adenoCa.
Multicentricity in ovarian serous Ca. If we find this over and over, it must b true. LGSCa near Endosalpingiosis in peritoneum. Hum Path 10.1016, 2022. Two cases in one day.@IJGConline
I am pleased to share our recently identified GYN marker. SOX17 is more specific than Pax8. It doesn’t express in kidney, thyroid, breast, lung, GI and many other organ tumors. It has been validated in clinical diagnosis at @MDAndersonNews recently.authors.Elsevier.com/a/1gOgG3B8d8sV…
Mucinous Ca in the Ov of an 18 yo Pt. Primary in the Ov bc the Ov cortex is abnormal. No cellular cortex and very few oocytes. Human Path 2021, 108:32. Nice to confirm previous observations not accepted by some reviewers.We need to listen to the tissue. @IGCSociety
Deep gaps in pathology training. Not enough emphasis on H&E. Obvious endometrioid carcinoma in ovary diagnosed as low grade serous carcinoma because of a wild type p53. @IGCS
Houston, we solved the problem(of ovarian serous Ts) Human Path 127,136-145,2022. Precursors in the ovarian stroma. Younger Pts-endosalpingiosis--> serous borderline-->LGSCa. Older Pts-simple cysts-->HGSCa These changes correlate with the development of the Mullerian system @IGCS
Using nice diagrams,researchers have shown us the two very different molecular pathways of serous Ts. Real, every day life, can b different. Serous LMP associated with HGSCa. In pathology we can do research every day, without a lab or a grant, and generating $.@IGCS
Early lesions r needed to find out how anything starts. Incidental HGOvCa. Only 5 microscopic lesions found. 3. In Ov, 1 in FT serosa, 1 in Ut serosa. They prove: 1-Multicentricity 2-Origin in flat epithelium in Ov, and in the stroma (Fere ex nihilo) in FT serosa.@IGCS
The lack of progress in Ovarian Ca. The morphology of Ts is the result of different genes. How r we going to find different genes if we call all these types Serous Ca? The tumors are saying: “we are different” @IGCS
Hi #PathTwitter We are still accepting applications for @MDAnderson GYN Pathology Fellowship for 2024-2025. DM me if you are looking for a high-quality material, top-notch GYN pathologists, and friendly environment.
Lack of progress in ovarian Ca. In 2011 I quit the WHO group. Some pathologists went for a uniform diagnosis: all high grade Cas + for p53 are Serous Ca. Based on H&E we need to separate the cases to find different molecular signatures important for targeted therapy.@IGCSociety
Congratulations to 2022 graduates. It was a pleasure to celebrate your accomplishments at our home. #mdandersonnews
AddThis | Home authors.elsevier.com/a/1f7poAfIPi6N… The origin of Serous Ts in the Ovary. A unifying theory re the origin of benign, borderline and Cas showing the significance of mesenchymal-epithelial transition and supporting the fere ex nihilo theory.@ IGCS
Excited to visit @MayoClinic to discuss endometrial cancer research! Great partnership with @MDAndersonNews @MSKCancerCenter #endcancer #oncsurgery @karenluMD @TaylorJolyn @LaurenPCobb @MikaylaMDPhD
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