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@aliceyting
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Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in @Nature 📣 They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic. More: bit.ly/4dUMU00
"Pathways for macrophage uptake of cell-free circular RNAs" Read more in @MolecularCell cell.com/molecular-cell… @StanfordMed @HowardYChang
Bidirectional epigenetic editing reveals hierarchies in gene regulation go.nature.com/4apFU9q
“Consensus changing” chemical biology at its finest, a new approach to modulating gene control. Neormorphic covalent ligands redirect the intently studied FOXA1 transcription factor, and instruct on pioneering functionality. A first TF-DNA glue? Way to go @Michael_A_Erb and Ben…
Together with the Cravatt group, we have a new manuscript out reporting the chemoproteomic discovery of covalent FOXA1 ligands that bind its DNA-binding domain, corrupt its motif preferences, and redistribute it on the genome. 1/11 biorxiv.org/content/10.110…
Beautiful review article on ecDNA in @NatureRevCancer by @HowardYChang @mischellab !! 🔥🔥👇🏻👇🏻 nature.com/articles/s4156…
Excited to share that our paper is out in @CellCellPress! We "lnc" Xist ribonuceloproteins (RNPs) to the greater prevalence of autoimmune diseases in biological females. A wonderful multi-institutional collaboration with @HowardYChang and many others! cell.com/cell/fulltext/…
Delighted to be honored by the King Faisal Prize. I am deeply grateful for all my mentors, collaborators, supporters, and especially lab members former and present. tinyurl.com/yssd6u8b
Very excited to see our paper with @doudna_lab @yimmieg @carlhjune @HowardYChang @BrandesNadav out in @CellCellPress !! Obligatory tweet-orial (X-torial??) coming soon... cell.com/cell/fulltext/…
🧬🚨Now online at @CellCellPress from @ConnorTsuchida with collaborators at @UCSF, @Stanford, @GladstoneInst, @Penn, and @parkerici Systematically studying the phenomenon and mitigation of Cas9-induced chromosome loss in clinical human T cells!
Huge congrats to Jason Buenrostro, who was just named a MacArthur Fellow! Fantastic news!
Meet the 2023 MacArthur Fellows: 20 inspiring individuals using creativity, curiosity, and care to build a more just and sustainable future. #MacFellow macfound.org/fellows
So when does ecDNA arise, exactly? Our study on #ecDNA and the transformation of pre-cancerous Barrett’s esophagus into cancer is out today. This collaboration brought together @Team_eDyNAmiC, @RFitzgerald_lab and the @FredHutch Seattle Barrett’s Study.🧵 nature.com/articles/s4158…
RIP Christopher T Walsh, a giant of chemical biology. Today @CarolynBertozzi’s Cancer Breakthroughs seminar at Stanford is dedicated to Walsh and the profound ways in which he influenced and inspired us all.
Our work on ENTER is finally out @CellCellPress! Like📱that can 📷📞🎧, ENTER is a modular viral platform that unifies multiple applications: ⭐️Decode Ligand-Receptor interaction ⭐️Receptor-specific cargo delivery ⭐️Link receptor specificity with cell state at single cell
A modular, lentiviral-based display and delivery platform enables decoding of ligand-receptor interactions, receptor-specific genetic cargo delivery, and mapping of receptor specificity and cell states of single cells @HowardYChang cell.com/cell/fulltext/…
Happy to share that our work is online @MolecularCell Our single-cell chromatin atlas of macrophage polarization reveals cyclical macrophage plasticity states in cell cycle. Great collaboration with Julia Belk, @HowardYChang & @Satpathology cell.com/molecular-cell…
Thrilled to share our paper in @NatureGenet! Cancer cells often amplify oncogenes outside chromosomes. We can now isolate and profile these large circular extrachromosomal DNA (ecDNA) molecules using a method called CRISPR-CATCH. 1/10 nature.com/articles/s4158…
Congratulations to postdoctoral researcher Bingfei Yu for receiving a Parker Bridge Fellowship. bit.ly/3qLHSN4 @BingfeiY @HowardYChang @parkerici @TheVFoundation
🤩OUT TODAY @NatureGenet 📰 The evolutionary dynamics of extrachromosomal DNA in human cancers 🧑🏿🤝🧑🏾 @mischellab @huang_weini @CancerGrand @howardychang @BenjaminWerner_ @anton_gh @jackrose and team 👇🏾 go.nature.com/3RY2nSS
Our (awesome) Biology department at Stanford has an open position for an assistant professor. The deadline is Oct 31st. Please RT. facultypositions.stanford.edu/cw/en-us/job/4…
Reactivation of latent HHV-6 in CAR-T cells. Terrific work by @CalebLareau in a close collaboration with many academic and industry colleagues. We hope this finding will help support the continued development of safe and effective cell therapies.
Encephalitis caused by human herpesvirus 6 has been repeatedly observed in CAR-T cell case studies and clinical trials. In a new work with @satpathology, we make the surprising observation that the cell therapy itself may be the source of lytic virus. biorxiv.org/content/10.110… 1/n
Immunotherapies are only as effective as their targets. Excited to share the launch of Cartography Bio, focused on finding safe and effective antigens for every cancer patient. Wonderful to work with founders @krparker @HowardYChang @MaxMumbach @CalebLareau @JeffreyVerboon
We’re excited to officially launch Cartography Biosciences today with $57M in initial financing. With this support, we will create a smarter roadmap for #cancer immunotherapies with our precision antigen expression atlas. 🧵 #Oncology #MedTwitter businesswire.com/news/home/2022…
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Who to follow
-
Feng Zhang
@zhangf -
Alice Ting
@aliceyting -
Jonathan Weissman's Lab
@JswLab -
Xiaole Shirley Liu
@XShirleyLiu -
Jay Shendure
@JShendure -
Jason Buenrostro
@JD_Buenrostro -
CTCF Papers 📚
@CTCF_Papers -
Rahul Satija
@satijalab -
Nucleosome papers 📚 NucPosDB database
@Nucleosome_Bot -
Gene Yeo’s Lab at UC San Diego
@yeo_lab -
Anshul Kundaje (anshulkundaje@bluesky)
@anshulkundaje -
dana_peer
@dana_peer -
Rong Fan
@RongFan8 -
Gene Regulation
@generegulation -
Arjun Raj
@arjunrajlab
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