David Ag
@Deyvid_AG🇲🇽 Neuropharmacologist, electrophysiologist, postdoc @scharfmanlab @nyulangone studying the early pathological alterations in Alzheimer's disease and epilepsy
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Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time…
Scientists may have discovered why ApoE4 causes Alzheimer’s disease and ApoE2 prevents it. Hint: the reasons are different. @Denalitx ow.ly/vMyS50Ukn90
“I wish it need not have happened in my time," said Frodo. "So do I," said Gandalf, "and so do all who live to see such times. But that is not for them to decide. All we have to decide is what to do with the time that is given us.” ― J.R.R. Tolkien, The Fellowship of the Ring
Dive into the intricate connections in the mouse brain! This video showcases 107 reconstructed neurons, thanks to the combined efforts of our teams at the Allen Institute, global collaborators, and tools from @GoogleAI Imaged using our cutting-edge ExA-SPIM microscope. 🧠✨
Microglial lysosomes may be a crucial incubator for amyloidosis. There, ApoE and Aβ co-aggregate, forming seeds of Aβ plaques. @DZNE_en ow.ly/wGET50TWHtC
JCI - Reactive microglia partially envelop viable neurons in prion diseases jci.org/articles/view/…
Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer’s disease @JExpMed rupress.org/jem/article/22…
Gomez-Murcia et al. show in a preclinical model of AD that early neuronal upregulation of the adenosine A2A receptor contributes to memory and synapse loss. The findings underscore the therapeutic potential of A2AR blockers, including caffeine. tinyurl.com/yeuj8ue8
There is a remarkable overlap in the brain impacts of COVID-19 & dementia. Our @NeurophysPIA led by @yangjiang addresses cognitive decline, slowed brain waves, epileptiform activity, and opportunities to monitor and understand these overlaps doi.org/10.1002/alz.14… @ISTAART…
Your Brain Age is less about mechanical ticks & more about entropic lifestyle & environment. In our @NatureMedicine, brain clocks speed up due to dementia, exposome (economic inequality, pollution), gender-health disparities, & regional factors👉 nature.com/articles/s4159… 🧵1/6
How do different neuronal populations and compartments determine molecular and synaptic diversity? Check out our collaborative effort for parallel transcriptomic and proteomic profiling of the hippocampus! @erin_schuman Lab at @MpiBrain @biorxiv_neursci
Our last work #JNeurosci @SfNJournals revealing transgenerational transmission of exercise 🏃🏻♀️effects on brain 🧠 & potential mediating microRNAs 🧬. Current JNeurosci issue jneurosci.org/content/44/23/… @InstitutoCajal @CSICdivulga @SENC_
Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer’s disease mouse model, as revealed by spatial transcriptomics: @CellReports cell.com/cell-reports/f…
Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer’s disease mouse model, as revealed by spatial transcriptomics cell.com/cell-reports/f…
Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease… ncbi.nlm.nih.gov/pmc/articles/P…
Alzheimer's Disease Pathophysiology in the Retina Review just published in "Progress in Retinal and Eye Research". This review addresses current and exploratory ophthalmic imaging modalities, such as optical coherence tomography (OCT), OCT-angiography, confocal scanning laser…
Glad to see this paper published (reviewed preprint) at @eLife regarding the effects of choline supplementation early in life in a model of AD 👇🏼 @scharfmanlab doi.org/10.7554/eLife.…
The Alzheimer's disease 2024 drug development pipeline An often heard critique is that the Alzheimer field is too “amyloid-centric”. The Figure below actually shows a well-diversified drug pipeline, which is highly needed. The mechanisms of action (CADRO) for agents currently…
Comparative anatomy of the dentate mossy cells in non-human primates: their spatial distributions and axonal projections compared with mouse mossy cells eneuro.org/content/early/…
Nice research on estrogen-GABA receptors in pain.
We are happy to share our new article about the role of ER-alpha on the expression and function of spinal alpha6 GABAA receptors in female rats with neuropathic pain that explain sex differences in the role of these receptors. doi.org/10.1016/j.ejph…
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Who to follow
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Scharfmanlab
@scharfmanlab -
Justin Botterill
@jjb930 -
Jiannis Taxidis
@JiannisTax -
Zoé Christenson Wick, PhD
@ZoeChristenson -
robert hunt 🔥
@hunt_lab -
BarabanLab
@BarabanLab -
Ute Häussler
@ute_fr -
UCI Epilepsy Research Center
@UCI_EpiCenter -
Brittney Boublil, PhD
@brittneyboublil -
Jordan Farrell
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Christos Lisgaras, MSc, PhD
@Chris_Lisgaras
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