COVaRiPAD
@COVaRiPADCOVID-19 Vaccine Responses in Patients with Autoimmune Disease Collaborative. Effort between @WUSTLmed and @UCSFMed #COVaRiPAD
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On behalf of the entire #COVaRiPAD team, we are thrilled to announce our preprint reporting humoral responses after BOTH doses of mRNA-based SARS-CoV-2 vax in 133 pts w/ chronic inflammatory diseases (CID) and 53 immunocompetent controls: medrxiv.org/content/10.110….
Great talk by @alhkim today at the @WUSTL_Rheum Translational Research Conference on immunosupression and SARS-CoV-2 vaccination! Great work again by all of the collaborators (too many to tag)! @IbdWustl @WashUID @WUSTLneurosci @wusm_pathology @UCSFRheum #Research #COVID19
Congrats to @niti_pawar who led the effort (as a @UCSFMedicine med student!) on another #COVaRiPAD manuscript! Job well done by the entire team!
On behalf of the co-authors, I am delighted to present our observations from the #COVaRiPAD cohort examining longitudinal changes in patient-reported outcomes following SARS-CoV-2 vaccination in the immunosuppressed: onlinelibrary.wiley.com/doi/10.1002/ac…
Another manuscript on longitudinal changes in PROS using PROMIS following SARS-CoV-2 vaccination, published from our group at the @COVaRiPAD cohort funded by @HelmsleyTrust 🧵 by 1st author @niti_pawar @UCSFMedicine 👇🏼
On behalf of the co-authors, I am delighted to present our observations from the #COVaRiPAD cohort examining longitudinal changes in patient-reported outcomes following SARS-CoV-2 vaccination in the immunosuppressed: onlinelibrary.wiley.com/doi/10.1002/ac…
On behalf of the co-authors, I am delighted to present our observations from the #COVaRiPAD cohort examining longitudinal changes in patient-reported outcomes following SARS-CoV-2 vaccination in the immunosuppressed: onlinelibrary.wiley.com/doi/10.1002/ac…
Whole lotta love for this project! Exciting to see this data shared at @DDWMeeting #DDW2022 #COVaRiPAD
Thank you, @ksdknews, for sharing the experience of one of many patients that are #immunocompromised ! @alhkim #COVID19 ksdk.com/article/news/h…
Thrilled to present our analysis of the relationship between the immunogenicity and reactogenicity of SARS-CoV-2 mRNA vaccine in immunosuppressed patients with chronic inflammatory disease in the @COVaRiPAD cohort, now out in @ACR_Journals: onlinelibrary.wiley.com/doi/10.1002/ac…
We have a long way to go but we won’t stop advocating for our patients. Just like our very own @alhkim who was interviewed for this article! Thank you, @edyong209 for writing this important piece! theatlantic.com/health/archive… @WUDeptMedicine #immunocompromised #COVIDvaccine
@COVaRiPAD New @MedCellPress 👉 reduced neutraliz. abs with TNFi esp. against B.1.617.2 Delta virus 👉 Neut titers of all TNFi pts below threshold for antibody-mediated protection @5 months 👉 3rd mRNA vaccine dose boosted neut antibody titers > 16-fold. sciencedirect.com/science/articl…
Now out in @MedCellPress from team @COVaRiPAD: Reduced Ab activity against SARS-CoV-2 B.1.617.2 Delta virus in serum of mRNA-vaccinated patients receiving TNFα inhibitors (cell.com/med/fulltext/S…). Thread below for details, but there's 1 new piece of data you'll want to see...
NEW PREPRINT FROM TEAM #COVaRiPAD: under the leadership of @MSDiamondlab & Rita Chen, those on TNFi monotherapy at higher risk of poor neutralization responses to B.1.617.2 (delta) variant at 3 & 5 mths post-vax, w/ poor Fc effector fxn capacity. 1/ medrxiv.org/content/10.110…
Will provide an update tomorrow, including some interesting delta cross-neutralization data, for those interested: Abst # 0457 Plenary I 11:45 AM meet.acrconvergence.org/meetings/YQMF9… And gotta thank @drmapaley for introducing UpSet plots to me. #ACR21 #ACRambassador
Awesome to see COVaRiPAD make Year in Review! @alhkim FTW! Aside from the useful COVID information, I learned a new type of graph - an "Upset plot" (see below) Slick way to describe how upset you are by how many rx your patients are taking 😅 #ACR21 #ACRambassador #UpsetR
Some more #COVaRiPAD work presented at #ACR21: @monicayangMD, Abs # 0113 Epidemiology & Public Health Poster I: COVID-19 & Vaccination 11/6, 0730 EDT Niti Pawar, Abs # 1590 Patient Outcomes, Preferences, & Attitudes IV: COVID-19 11/9, 0730 EST #ACRambassador
Will provide an update tomorrow, including some interesting delta cross-neutralization data, for those interested: Abst # 0457 Plenary I 11:45 AM meet.acrconvergence.org/meetings/YQMF9… And gotta thank @drmapaley for introducing UpSet plots to me. #ACR21 #ACRambassador
NEW PREPRINT FROM TEAM #COVaRiPAD: under the leadership of @MSDiamondlab & Rita Chen, those on TNFi monotherapy at higher risk of poor neutralization responses to B.1.617.2 (delta) variant at 3 & 5 mths post-vax, w/ poor Fc effector fxn capacity. 1/ medrxiv.org/content/10.110…
This week's top story: Glucocorticoids, B-cell depleting therapies may dampen immune response to #COVID19 vaccines. Study by @alhkim @P_DeepakIBDMD @TheBcellArtist @drmapaley @CiorbaGI @JaneOHalloran1 & @COVaRiPAD team @AnnalsofIM @WUSTL_Rheum bit.ly/3BMJfic
Really appreciate @annie3mer for highlighting our initial analyses from the @COVaRiPAD study in @stltoday And truly thank Melinda Freeman, one of our participants in the study for providing her thoughts also. stltoday.com/lifestyles/hea…
Plus too many more to name. We’d also like to thank our wonderful participants that volunteered their time (and blood) to help us with this project!
All star team: @alhkim @TheBcellArtist @P_DeepakIBDMD Wooseob Kim @drmapaley @JaneOHalloran1 @prestirwustled1 @vsv512 @sechahiin @MS_ResearchDoc Willie Buscher @CiorbaGI @LianneGensler @monicayangMD @marynak410 @patti_katz Kim Taylor @jdgrafmd @matloubian
Link to paper: ow.ly/XRwu50G18jk Link to brief interview: kmov.com/news/those-imm… #SARSCoV2 #vaccine #antibodies @WUDeptMedicine @WashUDPS @AnnalsofIM
(1/2) Some great news for our #autoimmune patients! Check out @alhkim interview with @KMOV about the “COVaRiPAD” study results that were published. We are so proud of this paper and the huge effort of the 60+ people involved in its creation. @WUGastro @WashUNeurology @COVaRiPAD
COVID-19 #vaccination elicited antibody responses in nearly nine out of 10 people with weakened immune systems ow.ly/XRwu50G18jk @alhkim @WUSTLMed @UCSFMedicine @WUSTL_Rheum; @WUSM_Pathology; @IBDWUSTL; @WUGastro; @WashUID; @WashUNeurology; @WashUGenetics; @WUSM_MolMicro
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