Alejandro Tejada Lapuerta
@Alejandro__TL@ELLISforEurope PhD Student in @fabian_theis lab. Interested in Machine Learning and biology.
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@_yji_
1/8 Happy to share Prophet, done with @_yji_ and @fabian_theis! We have trained a single model across more than 4.7M public cell experiments to predict phenotypic responses (IC50, Cell Painting morphology features, RNA expression, ...). One single model to predict everything.
1/6 Looking for neural estimators of entropic #OptimalTransport or simply cool applications of #FlowMatching? Excited by novel generative modeling tools for #SingleCell data? Check out our #GENOT #NeurIPS paper tinyurl.com/yc5deeke!
First (public) blog post - on single-cell, bubbles, and discovery yugeji.substack.com/p/half-a-glass…
Want to aggregate rare variants into a single gene score while capturing diverse functional effects → Check out DeepRVAT, my first paper lead with @brianfclarke now out in @NatureGenet DeepRVAT scores can be plugged into any testing framework to discover new disease genes.
🧵 1/9 Delighted to announce that #DeepRVAT is out today in Nature Genetics! Here's a recap of our tweetorial from the preprint, with updates for some exciting new results. It's been a joy to work with @Holtkamp_Eva, as well as @gagneurlab and @OliverStegle
Excited to present “scooby”, which models multi-omic profiles (scRNA-seq coverage & scATAC-seq insertions) directly from 500 kb DNA sequence at single-cell resolution. This was a fantastic collaboration co-led with @thisisjohahi biorxiv.org/content/10.110…
me after someone asks me to justify the decisions i made in my technical design
>getting billed for tokens i'm not even allowed to see
1/9 Thrilled to share our latest work on CRISPR-CLEAR with @DSeruggia and @danielevanbauer labs. Over the past years we've been improving CRISPR tiling screen resolution and we have something to show you! Check also out David's excellent tweetorial!
First pre-print from the lab! Together with @lucapinello and @danielevanbauer we developed CRISPR-CLEAR, an experimental and computational pipeline to dissect enhancers at nucleotide resolution. biorxiv.org/content/10.110…
The problem is the people who are successful in academia have hyper tuned their glam publishing mojo, sometimes even more than their actual scientific capability. Discussions about how to get science published in a glam journal will often dominate scientific discussions.
every man's dream
Really pleased and excited that Prophet is out! Congratulations @_yji_, @Alejandro__TL, @fabian_theis, and all the co-authors involved! 🎉 Check out the thread from Yuge below and the @biorxivpreprint here: biorxiv.org/content/10.110…
Do you run functional assays? Wish you could get more results without having to scale? If you’re not using Prophet, you’re leaving potential on the table. (Warning: pitch not tweetorial)
I'm stoked to announce our new end-to-end framework for perturbation analysis! Our scverse advisory committee highlighted that a maintained and well-documented framework for perturbation analysis is missing. Pertpy is our attempt to satisfy this request biorxiv.org/content/10.110…
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Who to follow
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Hana Aliee
@AlieeHana -
Lukas Heumos
@LukasHeumos -
Leon Hetzel
@leon_het -
Till Richter
@TillRichter6 -
Anna Schaar
@AnnaCSchaar -
Tingying Peng
@p_tingying -
Alessandro Palma
@ale__palmaa -
Laura Martens
@lauradmartens -
Artur Szałata
@arturszalata -
Dominik Klein
@Dominik1Klein -
Luca Eyring
@LucaEyring -
Roberto Amoroso
@roberto__mrs -
Sabrina Richter
@_sabrinarichter -
Felix Drost
@DrostFelix -
Yuge Ji
@_yji_
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