Adi Sethi
@wildtypecell(he/him) Postdoc @UCL | Chromatin, epigenetics and DNA replication enthusiast | 🇮🇳 🏳️🌈
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A friend asked me to explain DNA, RNA, and epigenetics. he said that others had tried before, but it didn’t click for him. I happen to play the piano, so I gave him a simple, albeit imperfect, analogy. After this analogy, he finally understood! Here’s the piano analogy. 🧵
Our study on how the human MCM2-7 helicase is loaded onto replication origins 🧬 is now online @Nature! 🎉 Our findings reveal that unlike in yeast, human MCM loading does not require ORC6 and can occur through multiple pathways. Read more here: rdcu.be/d1F6S
Online Now: Acute multi-level response to defective de novo chromatin assembly in S-phase dlvr.it/TG85ld
SpotMAX, our software tool for analysing multi-dimensional microscopy data, is finally out! 🎉 And conveniently, I just presented it at the #I2K conference 😀 A multi-year-long effort of many great collaborators and users. But what can SpotMAX do? A small thread
Thrilled to share our new work @biorxivpreprint: biorxiv.org/content/10.110… Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live cells. We reveal genome chromatin is essentially replicated from regions with greater nucleosome motions. 1/2
Wonderful news! Parafilm M rules! Very well-deserved recognition after helping so many other #NobelPrize winners achieve their breakthroughs! Congratulations @ParafilmM
This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans. Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals,…
Wow! So glad to see this and such an amazing victory for the C. elegans community! MicroRNAs were discovered in C. elegans and this really shows the importance of worm research. Congrats Victor and Gary 🎉
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
We mention creativity only in passing when training scientists. This needs to change because creativity is both crucial and teachable. Whatever level creativity you're at, you can always get better! biomedcentral.com/collections/ni…
it's fellowship szn! I spent *a lot* of time applying for postdocs + independent positions last year, and I want to share my notes. In this doc, I list deadlines, pay, and other 🔑 info on bio/theory positions I considered. DM me for advice anytime. docs.google.com/spreadsheets/d…
#NewIssue Ft cover art by Kehuitang Art Studio. He et al. reveal a protective effect of acetate against metabolic and cognitive impairments caused by sleep disruption. Inspired by Monet’s famous Water Lilies paintings, a “mitochondrion” boat drifts in a lotus pond full of water…
Very helpful! But consider colorblind-friendly color palettes 🎨 ggpubfigs only supports colorblind-friendly color palettes, so it is something users don't even need to think about :D github.com/JLSteenwyk/ggp… x.com/tangming2005/s…
Color Palettes for Data Visualization rpubs.com/mathetal/colors #rstats
10 key points for delivering an amazing scientific talk. After advising a dozen scientists on presentations I've compiled 10 key points for outstanding talks that keep coming up with clients. Checklist to make sure your next presentation is sound and visually resonates 🎓
New biggest enzyme (and possibly biggest protein): 45k residue polyketide synthase from Texan fish-killing algae! @photocyte @VikShende @BA81752 @BradMoore_SIO @ALPPhD @nathan00347208
Here's a render of a full eukaryotic replisome carrying out DNA replication. This was built using real .pdb data from @buildmodels I used this to make my latest video: (youtu.be/lv89fSt5jBY) But now I want to do a quick works cited 🧵 (1/ ?)
Now online! The fork protection complex promotes parental histone recycling and epigenetic memory dlvr.it/TBRfcV
'What is Life?' was published 80 years ago by Schrodinger – the Nobel Prize winning physicist – who speculated for the first time about a 'code-script' in the form of an 'aperiodic crystal'. So many molecular biology pioneers were inspired by this book. docs.google.com/file/d/0B9bX85…
Love this! A children's book called Arbi, about the model organism plant Arabidopsis thaliana. I would love to see such books about other model organisms too!
1/5 📢 Exciting news! My new book "Arbi the Model Plant" is now available in English, with Hebrew, Arabic, German, and Spanish versions to follow! 🌱📚
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