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Sven Dorkenwald

@sdorkenw

PhD student @PrincetonCS & @PrincetonNeuro, graduating Aug 2023. Student researcher @Google. Next up: Shanahan Fellow @AllenInstitute

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We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses! Explore the connectome: codex.flywire.ai Reconstruction paper: biorxiv.org/content/10.110… Annotation paper: biorxiv.org/content/10.110… 1/6


Incredibly proud and grateful to be part of the #FlyWire team that made this happen. This was an immensely collaborative project - on every level from early open data sharing, to tool building, to analysis - over many years, across many institutions. It's been a fantastic journey

Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today

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Sven Dorkenwald Reposted

Congrats on an epic achievement. What a long way we've come!

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Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today

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Sven Dorkenwald Reposted

"Big buzz! @Nature published ~a dozen papers on the most comprehensive map of neuronal connectivity to date, a connectome of a fruit fly brain! The FlyWire consortium includes @UW_NBIO affiliate Forrest Collman and Shanahan Fellow Sven Dorkenwald (@sdorkenw). @FlyWireNews

Largest brain map ever reveals fruit fly’s neurons in exquisite detail go.nature.com/4dx4qY7



Sven Dorkenwald Reposted

Papers reporting the fly whole-brain connectome were published in @Nature today 🎉 and it was my honor to write a News and Views about them Congrats to @sdorkenw, @SebastianSeung, @MurthyLab, @gsxej, and the @FlyWireNews team! + great 🧵 below from David nature.com/articles/d4158…

Here it is! A huge milestone in neuroscience – the complete connectome of the fly brain from the FlyWire team (@FlyWireNews). In this special issue, we have 9 research articles. I’ll try to summarize them in a couple threads starting here 🧵

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Sven Dorkenwald Reposted

Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today

Tweet Image 1

Sven Dorkenwald Reposted

What should we do? 🔹 Tax vehicles by weight. 🔹 Test vehicles for pedestrian and cyclist safety (still doesn’t happen in the US) 🔹 Require a CDL for the most gigantic vehicles Left alone, this problem will only worsen. Governments must step up. slate.com/business/2023/…


Sven Dorkenwald Reposted

Our paper with @RunzheYang describing the network statistics of the whole-brain connectome of a complete adult Drosophila brain is now available on BioRxiv! biorxiv.org/content/10.110… 1/6


Sven Dorkenwald Reposted

We posted our pre-print today describing how the Connectome Annotation Versioning Engine (CCAVE) supports analyzing and editing the worlds largest connectomics datasets biorxiv.org/cgi/content/sh…! @sdorkenw @csdashm @AllenInstitute @SebastianSeung!


Sven Dorkenwald Reposted

It’s done! LIONESS is out @naturemethods! With the pipeline you can not only create a dense 4D nanoscale reconstruction of living brain tissue, it allows to combine information on morphodynamics, molecular identity and neuronal activity. nature.com/articles/s4159… A 🧵…

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Sven Dorkenwald Reposted

Very exciting to see this monumental work out! We are humbled and proud for having contributed to this milestone in neuroscience with our cell shape proofreading service. Thanks a lot for this awesome opportunity @dddavi and @gsxej

We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses! Explore the connectome: codex.flywire.ai Reconstruction paper: biorxiv.org/content/10.110… Annotation paper: biorxiv.org/content/10.110… 1/6



Sven Dorkenwald Reposted

We mapped the connections between high order sensory inputs and memory cells in the octopus brain, first-ever reconstructed octopus memory circuit: data and principles of circuit assembly today in eLife doi.org/10.7554/eLife.…, joint work w/ @FlavieBidel @HebrewU& @Harvard,RT!👇

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Sven Dorkenwald Reposted

The release of the first whole adult fly brain wiring diagram marks a turning point for neuroscience: end-to-end reconstruction of neuronal information processing from sensory input to motor output. Congratulations to the entire team!

In our paper, we analyzed the ocellar circuit (image), produced a projectome between all brain regions, and computed information flow from input to output neurons. These barely scratch the surface of what one can now analyze! all ocellar neurons: flywire.ai/discover/ocell… 4/6

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Sven Dorkenwald Reposted

The current wave of interest is a good time to also promote our recently updated paper on neurotransmitter prediction directly from EM (a task humans struggle with). This was used to add nts -> sign to the just released full brain Connectome. biorxiv.org/content/10.110…

This is really nice. They have statistically inferred neurotransmitter type. There are even some simple simulations running using subnetworks: biorxiv.org/content/10.110…



Sven Dorkenwald Reposted

Building the FlyWire #connectome from the FAFB brain was a massive team effort. But neuroscientists need to find their favourite neurons in this huge dataset. We report an indexed parts list, systematically annotating all 127k neurons (Schlegel et al biorxiv.org/content/10.110…) 1/7

We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses! Explore the connectome: codex.flywire.ai Reconstruction paper: biorxiv.org/content/10.110… Annotation paper: biorxiv.org/content/10.110… 1/6



Sven Dorkenwald Reposted

4 years. 250 people. 2.7 million edits to proofread 127,000 neurons. The fly connectome is here! Preprint: Neuronal wiring diagram of an adult brain biorxiv.org/content/10.110… Explore it in Codex: codex.flywire.ai

We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses! Explore the connectome: codex.flywire.ai Reconstruction paper: biorxiv.org/content/10.110… Annotation paper: biorxiv.org/content/10.110… 1/6



Sven Dorkenwald Reposted

We're done! A historic milestone for neuroscience brought to you by the @FlyWireNews Consortium. Don't take my word for it. See the glory of the fly brain for yourself at flywire.ai/gallery

We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses! Explore the connectome: codex.flywire.ai Reconstruction paper: biorxiv.org/content/10.110… Annotation paper: biorxiv.org/content/10.110… 1/6



Sven Dorkenwald Reposted

Excited to announce the completion of the first adult brain connectome - FlyWire is the neuronal wiring diagram of a Drosophila melanogaster brain with >130K neurons and >32M synapses. Explore at codex.flywire.ai. Check out the preprints:

We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses! Explore the connectome: codex.flywire.ai Reconstruction paper: biorxiv.org/content/10.110… Annotation paper: biorxiv.org/content/10.110… 1/6



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