Ryan Shea
@ryanesheaCo-founder @Stacks & @opuswallet. Investments and ventures in biotech. Gospel: techno-optimism & the infinite frontier.
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Elon being the richest man in the world is the least interesting thing about him, yet that’s how he is labeled by nearly everyone. It’s more accurate to say that he owns more productive capital than anyone on earth, which is also a crushing responsibility with many burdens.…
If you voted Democrat and you are feeling that the election result is truly horrifying, do this one simple thing for your mental health: Write down your fears of what might happen in the next 4 years on a piece of paper. Re-read and check in on them every few months. It will…
If you're on the losing side of a landslide, there are two ways to react: 1) Eat the humble pie, listen, self-reflect, evolve, and come back better next time 2) Arrogantly proclaim that everyone is dumb except us, continue as you are, and make the same mistakes next time
I don't like to tweet much about politics, but if you respond to an overwhelming victory for people you profoundly disagree with by saying, "everyone is clearly stupid/evil", instead of triggering profound curiosity and reflection, you are part of the problem
Who would’ve thought that this election would be decided by raw milk and a pet squirrel
A US think tank interviewed the CCP about this and asked them if they tried to replicate the Marxist indoctrination at Berkeley. I’ll never forget their answer: “We can’t, we don’t know how.”
Tyler Cowen tries to have a rational conversation with a “rationalist” AI doomer. Finds out it’s impossible.
***VITALIA FOREVER 2025*** In early 2024, Vitalia’s genesis pop-up city attracted 500+ frontier technologists to build a permanent longevity biotech city district within @ProsperaHN, including @balajis @naval @brian_armstrong @bryan_johnson @aubreydegrey @davemcclure It was a…
Forget everything in startups you thought was possible from a legal standpoint. Gov agencies can no longer regulate industries without explicit laws passed in congress. We’re about to experience a tidal wave of innovation in entirely new categories of startups. Buckle up!
CHEVRON DOMINANCE Technology is about to accelerate. Because Chevron deference is over. And regulators can't just make up laws anymore. So, countless new startups just became feasible. This is often spoken about in the abstract, so let's do three examples and two visuals. THREE…
We need to stop referring to self-identified environmentalists as environmentalists and instead call them what they really are: degrowthers and communists
Margin Call is a postrat movie about the power of feeling and gut calls over purely cerebral decision-making
Yudkowsky in 1996: "Let's say that we want this meme [Singularity] to infect a majority of all receptive individuals. If necessary, we can retarget another version for a majority of all influential individuals, technologically sophisticated or otherwise."
Both gov spending and tax cuts add to gov debt So both make it harder to balance the budget But only gov spending comes out of your pocket Spending increases what we must inevitably collectively pay (via taxes and inflation) Tax cuts only defer payment until later
HPMOR and LessWrong were designed to capture the minds of a particular type of autist and convince them that they are the ones who are rational and normal, and the rest of the world is irrational and insane. From this ivory tower they can capture the minds of people who reason by…
No polite way to say it. The purpose of a system is what it does. Lesswrong is a system for grooming autistic people into fanatics of AI Doom, making use of their social disadaptation and bad taste. This works because the US at large has no intellectual culture to offer them.
"Our high quality generalization out of distribution" "Their shoddy unsubstantiated hypothesizing" HT @ElmoTheHokage
Your model is fast takeoff to doom will immediately follow the emergence of self improving LLMs, yes? And because of this you reject the ability for us to wait for concerning milestones to be concerned because by the time those milestones are hit we’re already doomed. So we must…
Sure but many things could be considered “potentially massively dangerous” including brain organoids. And LLMs are not self improving. Plus they understand nuance and human intention extremely well, directly contradicting the “do exactly what I say but not what I mean” machine…
Excited to share @nablabio is partnering with 3 of the world’s largest pharma cos to use integrated AI and wet-lab tech to design antibodies against challenging disease targets. Thrilled to also add @radicalvcfund who led our $26M Series A to the family! bit.ly/4dDk4lP
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