@mseumaar Profile picture

Mireia Seuma

@mseumaar

Postdoc @MRC_LMB in synthetic biology. Previously @IBECBarcelona

Joined May 2018
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Pinned

Here another chapter of my PhD work👇 great to work with @immunobananna @aj4re @BenLehner @Bennibolo

Presenting the first large-scale measurement of energetic couplings for a protein transition state! biorxiv.org/content/10.110… with @immunobananna @mseumaar @aj4re & @BenLehner



Mireia Seuma Reposted

Our history in Bri2-related amyloids is "extended" now! We mutagenized the peptides causing Danish and British dementia and quantified the aggregation propensity of 18,000 Bri2 random extensions!!

Amyloids “at the border” 🏔️ or how @mamartin_ok started deep mutagenising the peptides that cause British and Danish Dementia and ended up quantifying 18,000 random sequence extensions of ITM2B/BRI2. biorxiv.org/content/10.110…



Mireia Seuma Reposted

We presented the first global map of inhibitory allosteric sites for any protein here KRAS and the first comprehensive comparative map of the effects of mutations on the free energies of binding of a protein to multiple partners. nature.com/articles/s4158…


Mireia Seuma Reposted

Celebrating the peace of mind this #ERCCoG will bring to the lab. We can actually do our job now!🧪💻🍝

🔝#IBEC researcher Benedetta Bolognesi (@Bennibolo) awarded a prestigious ERC Consolidator Grant. 🏆#ERCCoG is one of the most competitive funding in the EU for researchers who are consolidating their independent research teams. 👉Read the news: mtr.cool/jxryohoeti

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Mireia Seuma Reposted

OBS #Genomics Seminar on #MAVE 📅 Thu, April 11, 10 am ET 🎤 @mseumaar (@IBECBarcelona) 📝 An atlas of #amyloid aggregation 🎤 @AmmarTareen1 (@CSHL) 📝 MAVE-NN: learning genotype-phenotype maps from MAVE 👉 Register: us02web.zoom.us/meeting/regist… #openscience

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Mireia Seuma Reposted

📣We are looking for speakers (students, postdocs, and new faculty <1 year in position) for our Variant Effects Seminar Series 🧬#genetic #variation #seminar. Are you interested in presenting or would like to recommend someone? Please fill out this form ⬇️ forms.gle/Udi92A5Pcsko36…


Mireia Seuma Reposted

I acabem l’any amb aquesta notícia. Molt content de veure com els resultats de la meva tesi poden acabar anant més enllà i content de formar part d’aquesta nova aventura! upf.edu/web/focus/noti…


Mireia Seuma Reposted

A new atlas reveals the genetic mutations that cause #amyloid beta fibril formation, a protein linked to #Alzheimer's disease. Understanding this mechanism is crucial for preventing some of the major pathologies that affect society. #madeatIBEC   ibecbarcelona.eu/a-new-atlas-un…


Mireia Seuma Reposted

Researchers @IBECBarcelona @CRGenomica provide an atlas of amyloid aggregation and identify a large set of likely pathogenic variants a that are specifically enriched at its polar N-3 terminal region @mseumaar @BenLehner @Bennibolo go.nature.com/3FPbqll

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Mireia Seuma Reposted

Here it is: the allosteric map of a protein. Want to find all the sites to target in your favourite undruggable protein? Here's how you can do it. >22k biophysical measurements for one protein (KRAS) Congratulations to @WengChenchun and @aj4re biorxiv.org/content/10.110…


While I was printing the last version of my phd thesis, our Atlas of Amyloid beta aggregation was out @NatureComms! Check it here nature.com/articles/s4146…. Glad to work with @Bennibolo @BenLehner🙏

Latest from our amyloid factory with @mseumaar and @BenLehner : Deep Indel Mutagenesis reveals an Atlas of Amyloid Aggregation. Most frequent comment mumbled while writing this paper: "Oh my - It’s such a stunning dataset!". biorxiv.org/cgi/content/sh…



Mireia Seuma Reposted

I have a funded position for a master student to join me at @BenLehner's lab @CRGenomica in Barcelona. Starting in Jan/Feb 2023, we will have fun doing DMS at the seaside! Please reach out if you are interested or know anyone who might.

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Mireia Seuma Reposted

TOMORROW: Don't miss the next Atlas of Variant Effects Alliance Seminar Series @varianteffects w/ @SchraivogelS Tuesday, Oct 4th (9am Pacific, 4pm UTC) The seminar is open to all! Find the zoom link at website bit.ly/3BukSXQ

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Mireia Seuma Reposted

#LLPS peeps in Barcelona - @BoeynaemsSteven is giving a talk tomorrow - 3PM @IBECBarcelona @IRBBarcelona Come and learn how phase separation can KILL 🥷 + exciting upcoming stuff from Steven's lab! ⬇️⬇️ ibecbarcelona.eu/event/ibec-irb… boeynaemslab.org/research


Mireia Seuma Reposted

Are you interested in @varianteffects and #functionalgenomics? Our #seminar series is looking for new organizing committee members. Visit our webpage for more details and to apply➡️ (bit.ly/3q10Oak) 🧬


Mireia Seuma Reposted

📢looking for a #postdoc combining experiments + bioinformatics? ‼️labs of @Bennibolo & yours truly @GenomeDataLab are looking for a shared postdoc ➡️protein biophysics + cancer genomics = very cool project! ➡️we want to understand why some mutations are toxic to tumor cells 👇


Mireia Seuma Reposted

Join us & @GenomeDataLab! Fundamental question + systematic approaches + multiple down-the-line applications 🔥

📢looking for a #postdoc combining experiments + bioinformatics? ‼️labs of @Bennibolo & yours truly @GenomeDataLab are looking for a shared postdoc ➡️protein biophysics + cancer genomics = very cool project! ➡️we want to understand why some mutations are toxic to tumor cells 👇



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