Matthew Merrins
@merrinslabWe study metabolic signaling in the pancreatic islet and its deficiency in diabetes.
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Looking for a fluorescent biosensor and don’t know where to start? Want a comprehensive overview of the field? Check out our new review in @ACSChemRev online now as an ASAP article! From co-first authors @AMMGest @AyseZSahan @yanghao_zhong doi.org/10.1021/acs.ch…
🚨📖New #DiabetesResearch led by @Andi_Microscopy from the @msolimena lab uses advanced 3D #microscopy 🔬 to investigate the structure and function of primary cilia in #BetaCells. The study has now been published in @NatureComms 👉nature.com/articles/s4146…
Wow! Mathematical modelling of insulin secretion, integrating many upstream and downstream processes - including dual effects of H2O2 and NADPH (and SENP1) at distinct points in secretion. From some colleagues in Maribor. sciencedirect.com/science/articl…
This Thursday 10/3 Danielle Dean @deanlab8 on alpha cells as amino acid and not glucose sensors.
Wednesday! - 9 am PT//12 pm ET 📢: us02web.zoom.us/meeting/regist… @DiabetesnPOD @ULBCDiabRes @AMP_CMDKP @ufdiabetes @IUSweetTweets @T1D_researcher @PennIDOM @DiabResearch @Diabetes_DRI @StanfordDRC @BCDiabResNet @T1D_TrialNet @JoslinDiabetes @Bruskolab @merrinslab @BennyScience
Super-excited to reveal our latest fluorescent voltage indicator, ASAP5, now online @NeuroCellPress! ASAP5 features higher responsivity and kinetics, allowing detection of single synaptic transmission events. The link gives free access until 2024.11.09: authors.elsevier.com/a/1joYd3BtfH9B…
A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria: Cell cell.com/cell/fulltext/…
A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria: Cell cell.com/cell/fulltext/…
You don’t wanna know how much antibody this project took - totally worth it, every last drop. biorxiv.org/content/10.110… Expansion microscopy of axonemal dyneins in islet primary cilia
Our new preprint presents 3D light-sheet imaging of the intact islet, focusing on β-cell subpopulations that lead and coordinate islet Ca2+ oscillations. Great collaboration between Erli Jin, @JenniferKBriggs, and @BennyScience . biorxiv.org/content/10.110…
Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system. science.org/doi/10.1126/sc…
The June #DiabetesBio #Podcast is now online! Topics include: Int. w/ Drs. Matthew Merrins & Richard Kibbey on Pont-Counterpoint feature in this months Diabetes Issue and more! 🎙️ diabetesjournals.org/diabetes/pages… @thewilliamslab @KirkMHabegger @DarleenSandoval @merrinslab @guy_rutter
Excited to share our recent preprint where we describe a novel somatostatin signaling pathway in beta cells involving cilia Ca2+ and cAMP changes and crosstalk with the hedgehog pathway. biorxiv.org/cgi/content/sh…
Meet MagLOV: an engineered protein that responds STRONGLY to magnetic fields. This is a fluorescence timelapse of MagLOV in E. coli. We're waving a (small) magnet under the plate. Can you tell where the magnet is? Want some? It's on Addgene now! addgene.org/219957/
Here, Lewandowski and team from @JCampbellLab score a goal for GIP not only being a strong potentiator of glucose-stimulated insulin secretion, but also of amino acid-stimulated glucagon secretion. Can this knowledge be used to counter hypos in #T1D? doi.org/10.1152/ajpend…
Come check out some EM badassery by @SanjaSviben ✨🔬 journals.biologists.com/jcs/article-lo…
A reminder of our discussion tomorrow on KATP channel regulation in beta cells. Q/A warmly welcomed!
📣 An epic discussion ➡ exploring both sides of this 🔑 key issue for #betacells! A chance to contribute your Q/A along with commentary. ⏰ MAY 16 @ 9am PT// 12noon ET// 5pm BST Join the conversation! 🔬 : lnkd.in/gHJ9KpbS
🏆Please join us in congratulating Prof Lori Sussel (@sussellab) on receiving the 18th Albert Renold Prize, awarded for her outstanding contributions to better understand the function of the pancreas.👏 Prize will be awarded during #EASD2024 in Madrid. #diabetes @CUAnschutz
⭐️Best of #DiabetesADA2023⭐️ | #09 ALTMETRIC Establishment of Pancreatic ?-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery -Kyosei Ueki et al. doi.org/10.2337/db23-0…… @ADA_Pubs
Looking forward to presenting/learning bioimaging in human type 1 diabetes. We will discuss challenges, progress, and roadmap to full clarification of human pancreatic function in context of type 1 diabetes with @thesugarscience on June 06. Register at us02web.zoom.us/meeting/regist…
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