Marvin Thielert
@marvinchthIMPRS PhD student at @labs_mann (@MPI_Biochem)
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"A new standard for understanding disease progression at the single-cell level in human tissue." Unraveling liver disease in Alpha1-antitrypsin deficiency with #DeepVisualProteomics. Another major step forward with spatial omics and #AI. biorxiv.org/content/10.110… @labs_mann…
We just release alphaDIA 1.8.2 including some new step-by-step guides for #Proteomics. Learn how to: • Run DIA searches from the GUI • Create custom PTM models with DIA transfer learning • Evaluate model performance with detailed metrics alphadia.readthedocs.io/en/latest/guid… #TeamMasSpec
AATD affects thousands, causing liver & lung disease via protein aggregation. Our new preprint used #DeepVisualProteomics to study liver cells and reveals key AATD insights with clinical implications . Video and tweetorial @metaboflo #Alpha1Awareness bit.ly/4hzl64o
Check out the excellent ’Dawn of spatial medicine’ blog of Eric Topol where he describes our TEN DVP paper from last week.
The Dawn of Spatial Medicine Until now, spatial omics was used to understand human biology. That changed when it saved lives of patients with a fatal skin condition. In the new Ground Truths, pioneering work by @labs_mann @NordmannThierry @MPI_Biochem and an international…
Published today! Spatial proteomics reveals JAK/STAT as a target for Toxic Epidermal Necrolysis, an often fatal skin reaction to common medication. We validated our findings in pre-clinical models & successfully treated the first patients worldwide.🧵⬇️ nature.com/articles/s4158…
Can a deadly rash be cured by repurposing drugs? Our @Nature paper says yes! Deep Visual Proteomics reveals JAK inhibitors as potential TEN treatment. A game-changer in #dermatology & #SpatialProteomics. Congratulations to all! @NordmannThierry's tweetorial explains below:
Published today! Spatial proteomics reveals JAK/STAT as a target for Toxic Epidermal Necrolysis, an often fatal skin reaction to common medication. We validated our findings in pre-clinical models & successfully treated the first patients worldwide.🧵⬇️ nature.com/articles/s4158…
Congratulations to Matthias Mann who receives the prestigious #HeinekenPrize for Biochemistry and Biophysics with Ruedi Aebersold for ‘revolutionizing the way proteins are studied’. ❕heinekenprizes.org/2024/06/11/rue… ❕biochem.mpg.de/mann @labs_mann #proteomics
Missed the Thermo User meeting at on Sunday on the new targeted MS? Our preprint on the Stellar MS shows how to use it in combination with the Orbitrap Astral and Evosep One to design 15N labeled protein based assays. Check out Maria Wahle’s poster ThP733 biorxiv.org/content/10.110…
Check out the first version of alphaDIA! A modular open-source search framework for DIA data with end-to-end transfer learning. Great work from @GeorgWa and team effort of @labs_mann
1/7 @labs_mann and Georg Wallmann @GeorgWa are proud to announce alphaDIA, our open source, next generation DIA search engine. Check out the preprint @biorxivpreprint biorxiv.org/content/10.110…
I am proud to announce that I successfully defended my PhD today. Thank you very much to @labs_mann @MPI_Biochem and @OvCa_UChicago for this unique journey!
I'll be presenting ✨SPARCS✨ our recently developed platform for microscopy-based genetic screens at genome scale in a webinar organised bei @LeicaMicro and @BitesizeBio soon! 🚀👩💻 Check out the details and register here: leica-microsystems.com/science-lab/li…
Thanks to @MichaelJFoxOrg for hosting the Bio-Hackathon, where @labs_mann represented by Matthias Mann and @OellerMarc, together with four other expert teams collaborated to investigate alpha-synuclein modifications in Parkinson's disease. michaeljfox.org/news/mjff-bio-…
It has been a great conference #HUPO2023, catching up with many and making new connections in Busan. I was honored to give a talk and finish as a runner up in the 3 minute thesis competition (3MT). Thank you to the organizers of HUPO and #ECR.
Congrats to Johannes @JoBMller for winning the HUPO manuscript competition and a big shout out to Marvin @marvinchth for the runner up finish in the 3 min thesis competition! Well done!
Big congratulations 👏 to @IreneGallina and @CosciaLab, former CPR post-docs, who have been awarded Prestigious @ERC_Research Starting Grants to establish their independent research groups 🏆👨🔬👩🔬 These awards greatly illustrate the impact and legacy of CPR’s research across 🇪🇺
Our journey of multiplexed DIA, encompassing applications in spatial #singlecell #proteomics, is showcased on the cover of the latest issue of @MolSystBiol We are excited about the prospects of sensitivity, reproducibility and high-throughput applications in clinical proteomics.
09/2023 Issue ➡️ embopress.org/toc/17444292/2… #multiomics in gut microbial communities, predicting fermentation function in wine yeast consortia from community composition... Cover: automated multiplexed DIA workflow for bulk or #singlecell #proteomics @labs_mann #SystemsBiology
Read our multiplex-DIA story in @MolSystBiol! Automated & complete dimethyl labeling up to 5-plex with LysN. Reference channel doubles proteomic depth in single cells & RefQuant ensures precise quantification. #Proteomics #Quantification #multiplexDIA pubmed.ncbi.nlm.nih.gov/37602975/
Do you want to perform high-sensitivity proteomics with multiplexed IF-staining and laser-capture microdissection? Check out our new method published @molcellprot, where we guide you through our novel antigen-retrieval method to accomplish this: pubmed.ncbi.nlm.nih.gov/37683827/
I am very excited to share the manuscript about our highly efficient immunopeptidomics workflow IMBAS. Combined with AlphaPeptDeep @jalew188 we acquire deep immunopeptidomes even from limited sample amounts. If you have any questions, feel free to reach out!
Read about our IMBAS technology for highly sensitive immunopeptidomics. We identify 10,000 MHC peptides from soluble complexes in plasma and reveal where they come from. doi.org/10.1101/2023.0…
A standardized and reproducible workflow for membrane glass slides in routine histology and spatial proteomics | buff.ly/485uTdz #proteomics
Read about our IMBAS technology for highly sensitive immunopeptidomics. We identify 10,000 MHC peptides from soluble complexes in plasma and reveal where they come from. doi.org/10.1101/2023.0…
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