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FDA Approves Revumenib for R/R Acute Leukemia With a KMT2A Translocation onclive.com/view/fda-appro… via @onclive First in class drug approval. This is great news. Several other menin inhibitors in trials right now. Will be interesting to see the differential activity in NPM1 mut…


Insurance companies are criminal. Was on hold for 30 minutes to set up a P2P for a AML patient and got no where! Maybe I should start to charge them for the time I spend on phone for this BS.


Insurance companies are so dumb! They will cover the allotransplant for a patient but not cover Tacro post transplant! I mean who makes these policies and have they ever worked in clinical medicine?


This is such a path breaking trial! It goes against all conventional thinking about allotransplant for AML. How this applies to NA where we don’t use FLAMSA-RIC ? @sghmd @BldCancerDoc @ouholter @Haemophage @nihardesai7 thelancet.com/journals/lanha…


Can someone explain to me how DLS works! India-W score 122, Bangladeshi-W score 68/7 in 14.4 overs before the game was called off. By DLS India-W win by 56 runs (68+56=124 which is more than what the Indian team scored)


Manu Reposted

FDA grants accelerated approval to ponatinib with chemotherapy for newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia Based on positive data with improvements in MRD-ve CR with ponatinib compared to imatinib with low intensity chemo! #Ph_pos_ALL


Manu Reposted

#Myeloma Paper of the Day: For patients with PD after quadruplet induction, response to next therap was 26.3% if PD <18 months & 52.6% if ≥18 months after the onset of a QUAD, while median PFS on next tx was 2.5 and 7.0 months: pubmed.ncbi.nlm.nih.gov/38291707/. Unmet medical need area!

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Manu Reposted

MRD in AML: who, what, when, where, and how? ow.ly/L4rQ50Quzpz #myeloidneoplasia

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Young, fit AML patient with NK and NPM-1 mutation. What’s your choice of induction?


Another #earthquake in Oklahoma City. This is the 4th one I have felt in less than 12 hours. What is going on?


Manu Reposted

ASH Abstract Koura et al = Calcineurin free GVHD PPx Randomized phase II Abatacept+PTCy vs CNI+MTX moderate/severe cGVHD = 0% vs 66%! No gut or liver aGVHD in aba+PTCy arm ash.confex.com/ash/2023/webpr… @sghmd

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Manu Reposted

Academic hospitalists needed! - Day-time direct care hospitalists (both teaching and non-teaching) - Oncology hospitalists - Nocturnists

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US has a testosterone abuse problem. Patients are on it for no good reason. Patients with cardiac problems, VTE, sleep apnea. I have even seen women on it for fatigue!!!! Agencies have turned a blind eye to this menace till it become a crises in the next 10 years.


TP53 mut AML/MDS. With such poor outcomes in these patients even with transplant should we continue to transplant? Only if using MAC and or MRD- pre transplant? Having a bad day with this horrible disease! 🥺🥺


CBF leukaemia with C-Kit mut. Dense mast cell aggregates with atypical morphology and CD25 expression. Is this SM-AHN? Can you see such mast cell aggregates in CBF AML with mut c-kit and would this still be considered a fav risk AML? @sanamloghavi @AaronGoodman33 @nihardesai7


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